Mutation News and Research

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Capturing the mechanisms underlying evolvability in a new framework

All life evolves: microorganisms can become resistant to drugs, viruses evade our vaccines, and species may adapt to climate change.

3 Mar 2022

Researchers find an epigenetic adaptation showing resistance to targeted therapy in T cell leukemia

Although gene mutations can result in drug resistance, scientists in the Perelman School of Medicine at the University of Pennsylvania have found a vital, non-genetic version that could also boost resistance to targeted treatment in T cell leukemia, which is a kind of blood cell cancer.

3 Mar 2022

Study uncovers genomic drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma

Cutaneous T-cell lymphoma (CTCL) is an incurable, rare cancer of skin-homing T cells that is highly disfiguring and lethal at advanced stages.

2 Mar 2022

Understanding mutational bias helps scientists predict how pathogens develop resistance to drugs

Genetic mutations help certain people succeed in the face of natural selection.

21 Feb 2022

Discovery of chiral evasion could lead to more resilient inhibitors, better drug designs

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial infection that has become resistant to most of the antibiotics used to treat regular staph infections.

18 Feb 2022

Novel tool for genome-wide design, evaluation of gRNA sequences for CRISPR experiments

Commercially viable biofuel crops are vital to reducing greenhouse gas emissions, and a new tool developed by the Center for Advanced Bioenergy and Bioproducts Innovation should accelerate their development -; as well as genetic editing advances overall.

18 Feb 2022

3D structure of protein channel helps shed light on sensitive touch response of Venus fly traps

Scientists at Scripps Research have revealed the three-dimensional structure of Flycatcher1, an aptly named protein channel that may enable Venus fly trap plants to snap shut in response to prey.

18 Feb 2022

UCI biologists discover how a gene variant protects against Alzheimer's disease

While the word "mutation" may conjure up alarming notions, a mutation in brain immune cells serves a positive role in protecting people against Alzheimer's disease.

15 Feb 2022

Genetic mutation introduced into human genome protects against Alzheimer’s disease, research says

Scientists were successful in editing the genome of human cells cultured in vitro to introduce a mutation offering protection from Alzheimer’s disease.

14 Feb 2022

Three proteins as potential new therapeutic targets in movement disorders

Three members of a family of proteins have been identified that are important to helping us fine tune the activity of brain chemicals which enable us to walk or stand at will, scientists report.

11 Feb 2022

Kras oncogenes use genetic reprogramming to drive tumorigenesis

Cancerous tumors are made up of rapidly growing, abnormally shaped, cells that can infiltrate and destroy healthy tissues, travel to other parts of the body, and form additional tumors.

8 Feb 2022

Different autism risk genes have similar effects on brain development, study finds

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery.

3 Feb 2022

Researchers provide first evidence of the gene-environment interaction in the social dysfunctions typical of autistic disorders

Autism spectrum disorders are characterized by a wide range of behavioral issues.

2 Feb 2022

Study offers insight into how activated protein C may protect aging patients from reperfusion injury

A University of South Florida Health (USF Health) preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

1 Feb 2022

Study identifies new therapy to treat cystic fibrosis

The process of making proteins from genes is similar to that of a factory, where employees must follow a set of instructions that are both effective and precise.

31 Jan 2022

Genetic mutation that corresponds to small body size in dogs existed in ancient wolves

Popular belief has been that small dogs, such as Pomeranians and Chihuahuas, exist because once dogs were domesticated, humans wanted small, cute companions.

28 Jan 2022

The Native Antigen Company Expands Range of Norovirus-Like Particles

The Native Antigen Company today announced the expansion of its norovirus-like particle range, with the addition of six new reagents.

From The Native Antigen Company 13 Jan 2022

New 'disease-in-a-dish' system developed to study oculocutaneous albinism

Researchers at the National Eye Institute have developed the first patient-derived stem cell model for studying eye conditions related to oculocutaneous albinism (OCA).

12 Jan 2022

Experts introduce new gene therapy approach for muscle weakness

Experts at Children’s National Hospital have created a new pre-clinical gene therapy for the rare condition limb-girdle muscular dystrophy (LGMD) 2B.

7 Jan 2022

Simple, marine-dwelling creature shines light on cancer resistance

A simple, marine-dwelling creature known as Trichoplax adhaerens has some remarkable properties. The organism can tolerate unusually high doses of radiation that would kill most other forms of life. T. adhaerens has another intriguing characteristic: the ability to resist cancer.

24 Dec 2021

Mutation News and Research

Capturing the mechanisms underlying evolvability in a new framework

Researchers find an epigenetic adaptation showing resistance to targeted therapy in T cell leukemia

Study uncovers genomic drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma

Understanding mutational bias helps scientists predict how pathogens develop resistance to drugs

Discovery of chiral evasion could lead to more resilient inhibitors, better drug designs

Novel tool for genome-wide design, evaluation of gRNA sequences for CRISPR experiments

3D structure of protein channel helps shed light on sensitive touch response of Venus fly traps

UCI biologists discover how a gene variant protects against Alzheimer's disease

Genetic mutation introduced into human genome protects against Alzheimer’s disease, research says

Three proteins as potential new therapeutic targets in movement disorders

Kras oncogenes use genetic reprogramming to drive tumorigenesis

Different autism risk genes have similar effects on brain development, study finds

Researchers provide first evidence of the gene-environment interaction in the social dysfunctions typical of autistic disorders

Study offers insight into how activated protein C may protect aging patients from reperfusion injury

Study identifies new therapy to treat cystic fibrosis

Genetic mutation that corresponds to small body size in dogs existed in ancient wolves

The Native Antigen Company Expands Range of Norovirus-Like Particles

New 'disease-in-a-dish' system developed to study oculocutaneous albinism

Experts introduce new gene therapy approach for muscle weakness

Simple, marine-dwelling creature shines light on cancer resistance

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

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