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Study reveals how the tumor suppressor gene plays a vital role in pediatric rhabdomyosarcoma

Scientists at St. Jude Children's Research Hospital have revealed how the tumor suppressor gene PTEN plays a more important role in pediatric rhabdomyosarcoma than was previously appreciated.

20 Sep 2021

Combining bacteriophages with antibiotics to treat antibiotic-resistant infections

Mycobacterium abscessus, a relative of the bacteria that cause tuberculosis and leprosy, is responsible for particularly severe damage to human lungs and can be resistant to many standard antibiotics, making infections extremely challenging to treat.

17 Sep 2021

Researchers reveal why nerve cell’s protein production slows down in CMT patients

A team led by MDC researcher Marina Chekulaeva has figured out why protein production slows down in the nerve cells of people suffering from Charcot-Marie-Tooth disease. This discovery could lead to a new therapeutic approach, the scientists report in the journal "Nucleic Acids Research".

16 Sep 2021

Loss of natural HIV control preceded by functional impairment of T cells

HIV is a master of evading the immune system, using a variety of methods to prevent the body from being able to find and kill it.

13 Sep 2021

Study imparts mechanistic understanding on early stages of human cancer

Scientists demonstrated that normal human fibroblast cells can be converted to specific cancer cells through factors that are identified in actual human patients.

9 Sep 2021

Study details replication and immune evasion of Delta SARS-CoV-2 variant

According to scientists, the Delta variant of SARS-CoV-2 has likely spread through its capability to avoid neutralizing antibodies and its heightened infectivity.

8 Sep 2021

New approach could lead to better treatments for mitochondrial diseases

Mutant DNA sequences inside cellular mitochondria can be eliminated using a bespoke chemical compound. The approach, developed by scientists at Kyoto University's Institute for Integrated Cell-Material Science (iCeMS) in Japan, could lead to better treatments for mitochondrial diseases.

31 Aug 2021

Genome editing tool used to render male mosquitoes infertile and slow disease spread

Mosquitos spread viruses that cause potentially deadly diseases such as Zika, dengue fever and yellow fever. New U.S. Army-funded research uses gene editing to render certain male mosquitoes infertile and slow the spread of these diseases.

24 Aug 2021

Study reveals the biology and treatment behind rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

20 Aug 2021

Novel genome-editing technology to mitigate Alzheimer’s disease

Around 500,000 patients in China alone are considered to be living with a hereditary form of Alzheimer’s disease (AD).

19 Aug 2021

Study describes a new method for identifying sperm mutations that can cause disease in children

Throughout development, life and the processes of aging, all human cells accumulate mutations, resulting in what is called mosaicism, a condition in which different cells in the same person have different DNA sequences or genetic makeup.

16 Aug 2021

New system solves 3D structures of RNA-only molecules with unprecedented speed and accuracy

The single-stranded genetic material RNA is best known for guiding the assembly of proteins in our cells and carrying the genetic code for viruses like SARS-CoV-2 and HIV.

16 Aug 2021

New technique to hunt down mutations that cause cancer drug resistance

Using a virus to purposely mutate genes that produce cancer-driving proteins could shed light on the resistance that inevitably develops to cancer drugs that target them, a new study led by UT Southwestern scientists suggests.

11 Aug 2021

Experimental small molecule could help treat Parkinson’s disease in future

A new study has demonstrated the removal of damaged mitochondria from the brain cells of mice treated with a small molecule compound for Parkinson’s disease.

5 Aug 2021

Study reveals melanoma is associated with a chemical conversion in DNA

According to recent research, the mutations giving rise to melanoma are the outcome of a chemical conversion in DNA triggered by sunlight.

3 Aug 2021

Study shows promising results for treating muscular dystrophies with umbilical cord-derived MSCs

Results of a compassionate-use study released in STEM CELLS Translational Medicine show promising results for treating muscular dystrophies with mesenchymal stem cells (MSCs) derived from Wharton's jelly (WJ), a substance found in the umbilical cord.

28 Jul 2021

New thin-film microfluidic device to manipulate β-lactoglobulin in milk

Researchers have manipulated beta-lactoglobulin, or β-lactoglobulin, by using an Australian-made innovative thin-film microfluidic device.

27 Jul 2021

Study applies novel AI tool to primary cancer genomes to identify mutation history

A new study has investigated the fragments of cancer DNA that arise from the human genome, the sequence of which is the outcomes of millions of years of evolution.

26 Jul 2021

Toward an antiviral drug that works against all coronaviruses

Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever.

22 Jul 2021

L452R mutation of SARS-CoV-2 spike protein is involved in cellular immunity evasion

A research team has demonstrated that the L452R mutation of the SARS-CoV-2 spike protein plays a role in cellular immunity evasion.

21 Jul 2021