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Hyperactive RANK protein could trigger autoimmune diseases

Autoimmune diseases, in which the body's own immune system attacks healthy tissue, can be life-threatening and can impact all organs.

3 Feb 2021

Researchers gain a deep insight into the evolutionary history of bitter receptors

To evaluate the chemical composition of food from a physiological point of view, it is important to know the functions of the receptors that interact with food ingredients. These include receptors for bitter compounds, which first evolved during evolution in bony fishes such as the coelacanth.

3 Feb 2021

Synthetic biomolecule resembles dual stimuli-responsive channel

For the first time, researchers from the Tokyo Institute of Technology (Tokyo Tech) and the University of Tokyo in Japan have produced a new artificial transmembrane ion channel—based on a naturally found transmembrane channel that plays a role in neuron signaling—that reacts to both electrical and chemical stimuli.

2 Feb 2021

Study shows how stem cell niche maintain their self-renewal capacity

A typical trait of all stem cells is their potential to renew on their own; however, scientists are unsure about how this ability is sustaining throughout life.

28 Jan 2021

Continuous in vitro monitoring could lead to faster, more effective treatments for chronic conditions

A world-first discovery by researchers at Monash University and The University of Queensland could lead to faster and more effective treatments for chronic health complications, such as cardiovascular disease and cancer, with 'fluorescent' in vivo biosensors.

27 Jan 2021

New CAR T therapy could be more effective and less toxic against neuroblastoma

CAR T therapy has transformed the treatment for leukemia. Regrettably, the therapy is not effective enough to treat solid tumors, like neuroblastoma.

22 Jan 2021

SARS-CoV-2 virus may enter and replicate in human cells by targeting cellular processes

The SARS-CoV-2 virus may enter and replicate in human cells by exploiting newly-identified sequences within cell receptors, according to work from two teams of scientists.

22 Jan 2021

Caffeinated coffee helps to minimize reductions in attention and cognitive function

A new study exploring the impact of repeated sleep loss during a simulated working week has found that consuming caffeinated coffee during the day helps to minimize reductions in attention and cognitive function, compared to decaffeinated coffee.

22 Jan 2021

Food choice may accelerate aging and shorten lifespan of fruit flies

Having a choice of foods may accelerate aging and shorten the lifespan of fruit flies, according to a study published today in the open-access eLife journal.

20 Jan 2021

Viral relatives of SARS-CoV-2 can evolve to evade the human immune system

Scientists have shown that two species of seasonal human coronavirus related to SARS-CoV-2 can evolve in certain proteins to escape recognition by the immune system, according to a study published today in eLife.

20 Jan 2021

Researchers develop more effective personalized immunotherapy for cancer patients

New research from CU Cancer Center member Jing Hong Wang, MD, PhD, and recent University of Colorado Immunology program graduate Rachel Woolaver, PhD, may help researchers develop more effective personalized immunotherapy for cancer patients.

15 Jan 2021

Nanobodies can prevent entry of SARS-CoV-2 coronavirus into human cells

Researchers at Karolinska Institutet in Sweden have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells.

13 Jan 2021

Augmented response of immune system explains COVID-19 severity in patients with hypertension

COVID-19 patients who also suffer from high blood pressure are more likely to fall severely ill with the disease, which also leaves them at greater risk of death.

12 Jan 2021

Advanced nanomaterial-based biosensing platform detects COVID-19 antibodies within seconds

Researchers at Carnegie Mellon University report findings on an advanced nanomaterial-based biosensing platform that detects, within seconds, antibodies specific to SARS-CoV-2, the virus responsible for the COVID-19 pandemic.

11 Jan 2021

Proteogenomic study may lead to more effective treatments for head and neck squamous cell carcinoma

Proteogenomic studies may provide a better understanding of how to match cancer patients with an effective treatment for their specific cancer.

8 Jan 2021

New class of protein materials can influence cell signaling

A new study has revealed that a novel class of protein material that communicates with living cells without being absorbed by them can affect cell signaling. The protein material does this by attaching and sequestering cell surface receptors.

7 Jan 2021

Researchers create molecular ON-OFF switches to regulate CAR T cell activity

CAR T cells are a breakthrough class of effective but often toxic cancer therapies. To prevent overactivation, switchable CAR T cells were engineered that can be turned on and off with an approved, widely used cancer drug.

7 Jan 2021

Researchers identify a vital protein needed to regulate anti-tumor immune response

Scientists from The University of Texas MD Anderson Cancer Center have identified a protein known as NF-kappa B-inducing kinase (NIK).

5 Jan 2021

Combination method can boost immunotherapy for breast cancer

According to a new study performed by scientists from the University of North Carolina, stimulating an immune signaling pathway, which is best known for combating bacterial and viral infections, can increase the potential of genetically engineered T cells to remove breast cancer in mice.

4 Jan 2021

Gut cells raise alarm during parasite invasion

To effectively combat an infection, the body first has to sense it's been invaded, then the affected tissue must send out signals to corral resources to fight the intruder.

29 Dec 2020

Receptor News and Research

Hyperactive RANK protein could trigger autoimmune diseases

Researchers gain a deep insight into the evolutionary history of bitter receptors

Synthetic biomolecule resembles dual stimuli-responsive channel

Study shows how stem cell niche maintain their self-renewal capacity

Continuous in vitro monitoring could lead to faster, more effective treatments for chronic conditions

New CAR T therapy could be more effective and less toxic against neuroblastoma

SARS-CoV-2 virus may enter and replicate in human cells by targeting cellular processes

Caffeinated coffee helps to minimize reductions in attention and cognitive function

Food choice may accelerate aging and shorten lifespan of fruit flies

Viral relatives of SARS-CoV-2 can evolve to evade the human immune system

Researchers develop more effective personalized immunotherapy for cancer patients

Nanobodies can prevent entry of SARS-CoV-2 coronavirus into human cells

Augmented response of immune system explains COVID-19 severity in patients with hypertension

Advanced nanomaterial-based biosensing platform detects COVID-19 antibodies within seconds

Proteogenomic study may lead to more effective treatments for head and neck squamous cell carcinoma

New class of protein materials can influence cell signaling

Researchers create molecular ON-OFF switches to regulate CAR T cell activity

Researchers identify a vital protein needed to regulate anti-tumor immune response

Combination method can boost immunotherapy for breast cancer

Gut cells raise alarm during parasite invasion

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