Signaling Pathway News and Research

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Study reveals new target to make breast cancer more sensitive to immunotherapy

Although immunotherapy has been effective in treating different kinds of cancer, it is still unsuccessful when it comes to treating breast cancers.

11 Dec 2020

Researchers identify molecular mechanisms that reverse aging

Cellular reprogramming can reverse the aging that leads to a decline in the activities and functions of mesenchymal stem/stromal cells (MSCs).

1 Dec 2020

Researchers identify promising treatments for late-onset Alzheimer’s disease

Scientists from The Mount Sinai Hospital and the National Center for Geriatrics and Gerontology based in Japan have recently discovered novel molecular mechanisms that drive late-onset Alzheimer’s disease (LOAD).

25 Nov 2020

Low levels of hydrogen peroxide can slow down cell aging

High levels of reactive oxygen species, called oxidants, are detrimental to cells in all organisms and have been associated with ageing.

10 Nov 2020

'Training’ the innate immunity may improve the success of immunotherapy

Immunotherapies, such as checkpoint inhibitor drugs, have made worlds of difference for the treatment of cancer. Most clinicians and scientists understand these drugs to act on what's known as the adaptive immune system, the T cells and B cells that respond to specific threats to the body.

30 Oct 2020

Scientists discover link between two signaling pathways crucial to growth of colon cancer

In breakthrough colon cancer research, scientists at ChristianaCare's Helen F. Graham Cancer Center & Research Institute have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The study is published today in the journal PLOS ONE.

29 Oct 2020

Researchers discover how specific molecules promote cancer progression

The development of cancer is a highly complicated process, involving multiple genes and signaling pathways that become upregulated or downregulated throughout different stages of tumor growth and spread. Two of the most commonly altered genes in cancer are p53 and AKT.

16 Oct 2020

Researchers identify drug that could overcome tumor resistance

Scientists have discovered that a drug that may make some melanoma tumors perceptible to the immune system, enabling them to be better targeted.

15 Oct 2020

Study provides new insights into molecular mechanisms of adipogenesis

The impairment of adipogenesis, the process in which fat cells (also known as adipocytes) accumulate to become fat tissue, can lead to many diseases such as diabetes, obesity, and heart conditions.

15 Oct 2020

Virus-mimicking drugs may overcome immunotherapy resistance in tumors

Researchers at the UCLA Jonsson Comprehensive Cancer Center have found that a drug that activates the body's natural defenses by behaving like a virus may also make certain stealthy melanoma tumors visible to the immune system, allowing them to be better targeted by immunotherapy.

15 Oct 2020

Researchers investigate the role of auxin in regulating pathogen gene expression

Scientists have long known that the plant hormone auxin controls many aspects of plant growth, development, and responses to the environment. Only more recently have they begun to understand that there is also a link between auxin and leaf spotting diseases.

7 Oct 2020

Cancer mutations occur in distinct patterns based on 3D structure of the genome

A new study from researchers at The University of Texas MD Anderson Cancer Center has discovered that mutations found in cancers do not accumulate randomly, but are found in distinct patterns that vary based on the three-dimensional organization of the genome in the cell as well as the underlying factors causing the mutations.

6 Oct 2020

Research finds gene family critical to unlocking vertebrate evolution

New University of Colorado Boulder-led research finds that the traits that make vertebrates distinct from invertebrates were made possible by the emergence of a new set of genes 500 million years ago, documenting an important episode in evolution where new genes played a significant role in the evolution of novel traits in vertebrates.

17 Sep 2020

Researchers unravel the molecular basis underlying colorectal cancer

A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.

15 Sep 2020

Researchers discover link between defensive responses in plants and crop parasite

Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) in Japan have discovered a link between defensive responses in plants and the beautiful but devastating crop parasite witchweed.

3 Sep 2020

Study shows strigolactones enhance tolerance to insects in tobacco plants

A team of researchers at the Max Planck Institute for Chemical Ecology in Jena, Germany, has discovered that strigolactones, a class of novel plant hormones, mediate the fine-tuning of the production plant defensive substances in the stem of plants of the wild tobacco species Nicotiana attenuata.

25 Aug 2020

Researchers identify a novel molecular mechanism of intestinal stem cells

Stem cells in the intestines maintain an excellent balance between two promising forms—developing into intestinal epithelial cells, or remaining as stem cells.

24 Aug 2020

Biologists identify a molecular mechanism that underlies phenotypic plasticity

Evolutionary and developmental biologist Craig Albertson and colleagues at the University of Massachusetts Amherst report that they have identified a molecular mechanism that allows an organism to change the way it looks depending on the environment it is exposed to, a process known as phenotypic plasticity.

29 Jul 2020

Researchers identify how airway cells work together in regeneration and aging

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases -- creating more of themselves and producing mature airway cells -- to regenerate lung tissue after an injury.

28 Jul 2020

Researchers to develop new ways to prevent esophageal cancer

The incidence of esophageal adenocarcinoma has increased 8-fold over the past 50 years. This is one of the deadliest cancers, with a five-year survival rate of only 20 percent.

14 Jul 2020