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Cancer-Associated Gene MYC Found to Drive Muscle Growth Independently of Exercise

Researchers have long known that there is a relationship between the cancer-associated gene MYC (pronounced "Mick") and exercise adaptation.

4 Dec 2024

Amborella trichopoda sheds light on ZW sex chromosome evolution in angiosperm plants

A recent study characterizes the ZW sex chromosomes in Amborella trichopoda, revealing insights into sex determination and early evolutionary dynamics in plants.

4 Dec 2024

Comprehensive Review of Intracellular Checkpoints in NK Cell Biology and Cancer

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their presence in tumors correlates with improved patient outcomes in a variety of cancers.

29 Nov 2024

The Role of RNA Polymerase and Ribosomes in Gene Expression

DNA within a cell contains the genetic instructions necessary for building proteins.

29 Nov 2024

Reduced Protein Mobility Linked to Chronic Diseases and Their Complications

Chronic diseases like type 2 diabetes and inflammatory disorders have a huge impact on humanity. They are a leading cause of disease burden and deaths around the globe, are physically and economically taxing, and the number of people with such diseases is growing.

28 Nov 2024

Study Reveals Molecular Mechanism Behind Neural Fate Commitment

The Wistar Institute's Alessandro Gardini, Ph.D., and lab have shed new light on how certain biological processes determine the development of neural cells. Their findings on a molecular "bridge" complex demonstrate a new level of detail in the understanding of early neural development -; which is fundamental for the further understanding of neurodevelopmental syndromes.

27 Nov 2024

Cyanobacteria Harness Pulse Amplitude Modulation to Control Biological Functions

Cyanobacteria, an ancient lineage of bacteria that perform photosynthesis, have been found to regulate their genes using the same physics principle used in AM radio transmission.

26 Nov 2024

Unveiling the Hidden Potential of SnoRNAs

Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence cellular processes, disease development, and overall organismal health.

25 Nov 2024

Unmasking the Molecular Mechanisms of Melanoma

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.

24 Nov 2024

Discovery of Large Tandem Duplications Opens New Avenues for Cancer Treatment

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.

21 Nov 2024

Novel Mechanism Revealed for Zygotic Genome Activation in Drosophila

Early development of an embryo is solely supported by maternally deposited RNAs and proteins until its own genome is activated through a process called zygotic genome activation (ZGA).

20 Nov 2024

Understanding Marine Worms’ Unique Ability to Regenerate Lost Body Parts

Many living organisms are able to regenerate damaged or lost tissue, but why some are particularly good at this and others are not is not fully understood.

19 Nov 2024

Plastics in Wastewater Found to Harbor Foodborne Pathogens

The study identifies pathogens in plastispheres from WWTPs, underscoring the environmental risks of microplastics and the need for better management strategies.

18 Nov 2024

Caterpillar Fungus Compound Blocks Cancer Growth Signals Within 30 Minutes

Cordycepin, derived from fungi, shows promise in cancer therapy by inhibiting growth factor signaling pathways critical for cell proliferation and survival.

15 Nov 2024

Study Reveals How Chronic Immune Signaling Can Promote Cancer

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in unexpected ways -; ways that have important implications for the development of cancer, researchers at Memorial Sloan Kettering Cancer Center (MSK) are discovering.

6 Nov 2024

The Role of Neural Crest Stem Cells in Cellular Reprogramming

Researchers at the University of Toronto have identified that neural crest stem cells, a group of cells located in the skin and other parts of the body, are the origin of reprogrammed neurons previously discovered by other scientists.

4 Nov 2024

New Discovery Shows TAGLN2 Protein Boosts T Cell Immunity Against Tumors by Enhancing Lipid Metabolism

Findings indicate ovarian cancer disrupts CD8+ T cell metabolism through FABP5 and TAGLN2, suggesting new therapeutic targets for enhancing immune function.

1 Nov 2024

A New Method to Reprogram Plant Cells Offers Insights into Cell Wall Development

A new method developed by Penn State biologists allows them to turn stripped-down plant cells into other types of cells, similar to the way stem cells differentiate into different cell types. Using this method, the research team explored the banding patterns that increase the stability of plant cell walls -; much like the corrugated patterns in cardboard -; and how they are created.

1 Nov 2024

Novel Mechanism for GRB2-SOS1-Mediated Liquid-Liquid Phase Separation

Researchers at Tokyo Metropolitan University have discovered new details about how the proteins GRB2 and SOS1 in cells transmit signals from membrane receptors to nuclei.

28 Oct 2024

Mobile Genetic Elements Alter Antagonistic Strategies of Gut Bacteria

Bacteria evolve rapidly in the human gut by sharing genetic elements with each other. Bacteriodales is a prolific order of gut bacteria that trade hundreds of genetic elements.

25 Oct 2024