Transcription News and Research

RSS

Mitochondria play a crucial role in the regulation of the NF-κB signaling pathway

Mitochondria are highly regarded as the cell's powerhouse. However, these cellular organelles are essential for more than only energy production: Professor Konstanze Winklhofer and her colleagues at Ruhr University Bochum’s Faculty of Medicine have found that mitochondria play an essential role in signal transduction in innate immune pathways.

21 Nov 2022

Revealing the functional significance of DDX41 in great detail

The DDX41 gene encodes the nuclear enzyme DEAD-box-type RNA helicase. Hematopoietic malignancies are caused by DDX41 mutations. However, the mechanism behind the development of this malignancy remains unknown.

21 Nov 2022

Statistical methodology uncovers changes in genomic data

A novel statistical technique makes it easier to find biologically significant changes in genomic data that span multiple conditions, like cell types or tissues.

From Penn State University 15 Nov 2022

Regulating cholesterol production with novel protein

Everyone must have heard about cholesterol and how important it is to eat heart-healthy meals to keep it under control.

From The University of New South Wales (UNSW) 8 Nov 2022

Providing structural understanding of the influenza virus

The structure of the influenza replication machinery and how it interacts with cellular proteins have been solved by a team of Oxford University scientists using a variety of techniques at Diamond Light Source.

8 Nov 2022

Researchers uncover a mechanism of flowering plant sperm compaction

Sperm cells have compact bundles of DNA, yet exactly how and why sperm cell nuclei are condensed in flowering plants has been a mystery, until now.

4 Nov 2022

Role of p53-mediated metabolism in preventing genomic instability

The gene that codes for the protein p53 is most likely the most significant factor in defending human cells against DNA-damaging agents that cause cancer. The protein permits cells to repair DNA damage and so prevents the formation of malignancies, earning it the nickname “guardian of the genome.”

4 Nov 2022

Low protein synthesis in humans causes rare intestinal disease

According to a recent study, which will be published on November 1st, 2022, by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues, a decrease in protein synthesis in growing gut cells contributes to a rare genetic condition, and an affordable nutritional supplement could help reverse that decrease.

3 Nov 2022

New technique could help fine-tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

2 Nov 2022

Understanding the architectures of proteins and the machinery at genes

Researchers from Cornell University have discovered a crucial mechanism in how genes are controlled thanks to yeast, a small organism that is necessary for the production of beer and bread.

1 Nov 2022

Plant root reprogramming via synthetic genetic circuits

An essential stage in genetically modifying plants to create better bioenergy crops is gene activity control. The results of this research led to the creation of artificial genes that could be coupled to produce certain patterns of gene expression in plants.

28 Oct 2022

All normal human tissues express remnants of widespread retrovirus

Ancient viral remnants in the human genome are active in both healthy and diseased tissues, restricting their applicability as disease indicators, according to a study published on October 18th, 2022, in the open access journal PLOS Biology by Aidan Burn at Tufts University in Boston, USA and colleagues.

20 Oct 2022

Innovative method opens myriad new avenues for understanding the biology behind COVID-19

A highly innovative method using the latest technology has generated a comprehensive list of SARS-CoV-2 viral and human proteins that interact with each other, with one such interaction showing the virus directly influencing proteins that regulate the human immune system.

18 Oct 2022