New optical tool controls bacterial electrical signaling

Bacteria, like neurons in human brains, utilize electricity to interact and react to environmental cues. Scientists have now developed a strategy to regulate this electrical signaling in bacteria to better comprehend antibiotic resistance.

Antibiotic Resistance

Image Credit: Kateryna Kon/Shutterstock.com

This potent tool will aid in the advancement of knowledge about bacterial infections, including the global threat of antimicrobial resistance. This is because such electric signaling is associated with antibiotic uptake, resulting in some bacteria sustaining antibiotic exposure.

Researchers from the University of Warwick and Politecnico di Milano described significant progress in controlling bacterial electric signals with light in research published in Advanced Science. The researchers used Ziapin2, a molecule that adheres to bacterial membranes and alters structure upon light exposure (a so-called “photoswitch”).

We found that upon exposure to blue-green light, bacteria showed an electrical pattern known as hyperpolarisation. We showed that Ziapin2 causes special channels to open, causing electrical changes in bacterial cells.”

Dr Munehiro Asally, Associate Professor, Life Sciences Department, University of Warwick

Dr Tailise de Souza, postdoctoral researcher at the University of Warwick says, “Though in its early stages, this technique may help us in the future to better understand microbial phenomena, such as cell-to-cell signaling, efficacy of antibiotics, and antimicrobial resistance.”

The introduction of light-methods in bacteria can potentially open up new exciting research routes. Apart from bringing a new tool for antimicrobial resistance studies, this approach can be exploited to build up bacterial hybrids that can perceive light and perform useful tasks, such as drug delivery in hard-to-reach body locations.”

Giuseppe Paternò, Assistant Professor, Physics, Politecnico di Milano University

Source:
Journal reference:

De Souza-Guerreiro, T. C., et al. (2023) Membrane Targeted Azobenzene Drives Optical Modulation of Bacterial Membrane Potential. Advanced Science. doi.org/10.1002/advs.202205007.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    The University of Warwick. (2023, February 15). New optical tool controls bacterial electrical signaling. AZoLifeSciences. Retrieved on July 16, 2024 from https://www.azolifesciences.com/news/20230215/New-optical-tool-controls-bacterial-electrical-signaling.aspx.

  • MLA

    The University of Warwick. "New optical tool controls bacterial electrical signaling". AZoLifeSciences. 16 July 2024. <https://www.azolifesciences.com/news/20230215/New-optical-tool-controls-bacterial-electrical-signaling.aspx>.

  • Chicago

    The University of Warwick. "New optical tool controls bacterial electrical signaling". AZoLifeSciences. https://www.azolifesciences.com/news/20230215/New-optical-tool-controls-bacterial-electrical-signaling.aspx. (accessed July 16, 2024).

  • Harvard

    The University of Warwick. 2023. New optical tool controls bacterial electrical signaling. AZoLifeSciences, viewed 16 July 2024, https://www.azolifesciences.com/news/20230215/New-optical-tool-controls-bacterial-electrical-signaling.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of AZoLifeSciences.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Researchers develop new sensors to detect gene activity