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Huntington's Disease Protein Disrupts DNA Repair

Researchers at McMaster University have found that the mutated protein in Huntington's disease patients disrupts DNA repair as it should, which affects the capacity of brain cells to regenerate.

30 Sep 2024

A New Understanding of the Effects of Fever on Immune Cells

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -; in a particular subset of T cells -; cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered.

23 Sep 2024

Enzyme Therapy Shows Promise for Parkinson's Disease

A preclinical investigation conducted by Weill Cornell Medicine researchers has shown an unexpectedly important role for an enzyme called PGK1 in the synthesis of chemical energy in brain cells.

22 Aug 2024

Research Unlocks Secrets of Stem Cell Retention in Bone Marrow

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells. The findings, made in mice, were published today in the journal Science.

9 Aug 2024

Flu Virus Exploits Immune System Weakness to Infect Cells

The majority of influenza viruses enter animal or human cells through particular surface-based pathways. It has recently been found by researchers at the University of Zurich that some influenza viruses, both human and avian, can also enter cells through a second entry point that involves an immune system protein complex.

18 Jul 2024

How an obesity gene influences brain function

A complex condition, obesity is brought on by a confluence of factors including behavior, diet, and heredity. Getting enough food to survive and thrive was a challenge for millennia.

16 Jul 2024

AI Uncovers Cancer Drivers in Non-Coding DNA

Researchers at the Garvan Institute have discovered putative drivers of cancer concealed in so-called "junk" DNA regions, creating opportunities for novel approaches to diagnosis and treatment using artificial intelligence.

3 Jul 2024

Flower Bulbs and Compost Carry Hidden Threat of Fungal Infection

That pile of soil you bought at the home improvement store may contain more than just dirt, according to new research from the University of Georgia.

26 Jun 2024

Breakthrough Study Identifies Critical Protein for Blood Stem Cell Self-Renewal

UCLA scientists have identified a protein that plays a critical role in regulating human blood stem cell self-renewal by helping them sense and interpret signals from their environment.

6 Jun 2024

Cryo-EM Reveals Structural Insights Into ADAM17/iRhom2 Complex

Efficient communication between cells is vital for many biological processes, such as recruiting immune cells to combat disease.

24 May 2024

Herpes Gene Therapy Achieves 90% Viral Reduction in Pre-Clinical Studies

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

16 May 2024

Genetic Link to Persistent HPV Infections Identified

Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide.

15 Apr 2024

Study Reveals Genetic Underpinnings for Cervical Cancer Risk from Persistent HPV Infections

Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide.

12 Apr 2024

Study Reveals Key Role of STAP-1 in Immune Function

A recent study has illuminated the significance of the protein STAP-1 in activating specific immune cells.

13 Mar 2024

The Surprising Impact of Chaperone Proteins on Multicellular Evolution

In a recent study, scientists used an instrument known as “experimental evolution” under the direction of researchers from the University of Helsinki and the Georgia Institute of Technology.

11 Mar 2024

Grasping the Concept of Mendelian Randomization

Mendelian randomization, a key method in medical research, aids in determining whether certain factors actually cause disease.

4 Mar 2024

Paleogenomics Unveils the Evolutionary Journey of Modern Humans

Writing a commentary in the 50th anniversary issue of Cell, FU Qiaomei and E. Andrew Bennett, both of the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences, explored the contribution of paleogenomics to our understanding of the evolution of modern humans.

1 Mar 2024