Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.
With age, cells can experience senescence, a state where they stop growing but continue releasing inflammatory and tissue-degrading molecules.
Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.
An autoimmune disease occurs when the body’s own cells are attacked by the immune system in addition to external pathogens.
This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr. Xuguang Du (College of Biological Sciences, China Agricultural University) and illustrated the key role of Mettl3 in CD8 T cell response during acute infection model.
Mesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases.
Mesenchymal stem cells (MSCs) have protective effects on the cornea, lacrimal gland, retina, and photoreceptor cell damage, which may be mediated by exosomes (exos) released by MSCs.
A new research paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, "Apoptotic cells may drive cell death in hair follicles during their regression cycle."
Apoptosis, frequently described as programmed cell death, is a fundamental mechanism essential for the growth and development of multicellular organisms.
At the UCLA Jonsson Comprehensive Cancer Center, scientists have uncovered a novel function for a protein known as extracellular signal-regulated kinase (ERK) within a pathway activated by interferon-gamma, capable of inducing cellular self-destruction.
A new study suggests rough surfaces inspired by the bacteria-killing spikes on insect wings may be more effective at combatting drug-resistant superbugs, including fungus, than previously understood.
Investigators from the University of Trento’s Physics Department discovered a link between the effect of radiation on DNA and the time when the damaged molecule breaks irreversibly.
A new editorial paper was published in Oncotarget's Volume 14 on June 21, 2023, entitled, "Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability."
Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.
A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Targeting cellular respiration as a therapeutic strategy in glioblastoma."
A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.
A new editorial paper was published in Oncotarget's Volume 14 on April 10, 2023, entitled, "Tumor necroptosis promotes metastasis through modulating the interplay between tumor and host immunity."
Researchers at the University of Geneva have developed a novel optical imaging approach that provides a four-dimensional view of cell secretions in real-time, including their spatial and temporal dynamics.
Understanding how cancer develops is critical for designing effective, personalized cancer therapies. Researchers have known for years that cancer begins with mutations in certain types of genes.
A scientific instrument at the Department of Energy's Oak Ridge National Laboratory could help create a noninvasive cancer treatment derived from a common tropical plant.
New research has shown that the blood vessels that feed aggressive brain tumors have receptors that could allow a new type of drug-containing nanoparticle to be used to starve the tumors of the energy they use to grow and spread, and also cause other disruptions to their adapted existence, even killing themselves.