Many people start to feel pain and stiffness in their bodies over time. Sometimes their hands or knees or shoulders get sore and are hard to move and may become swollen. These people may have arthritis. Arthritis may be caused by inflammation of the tissue lining the joints. Some signs of inflammation include redness, heat, pain, and swelling. These problems are telling you that something is wrong. Joints are places where two bones meet, such as your elbow or knee. Over time, in some types of arthritis but not in all, the joints involved can become severely damaged. There are different types of arthritis. In some diseases in which arthritis occurs, other organs, such as your eyes, your chest, or your skin, can also be affected. Some people may worry that arthritis means they won’t be able to work or take care of their children and their family. Others think that you just have to accept things like arthritis.
The reason why some people age worse than others and develop diseases linked to the aging mechanism is largely unknown.
Scientists revealed the operational mechanism of possible drug targets for numerous diseases like rheumatoid arthritis, cancer, and even COVID-19.
Tiny synthetic particles known as dendrimers have been shown to avoid detection by our immune system and so could be used to develop a new system to deliver drugs into the body without triggering a reaction.
With a goal of developing rheumatoid arthritis therapies with minimal side effects, researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, will deliver a biologic drug in response to inflammation.
In recent years, scientists have developed monoclonal antibodies -; proteins that mimic the body's own immune defenses -; that can combat a variety of diseases, including some cancers and autoimmune disorders such as Crohn's disease.
NYU Tandon professors Mary Cowman and Jin Ryoun Kim recently published a paper describing a novel peptide with broad therapeutic potential to combat chronic inflammation in multiple diseases.
Researchers from Johns Hopkins Medicine say they have added to evidence that a protein called CaMKII improves strength, endurance, muscle health and fitness in young animals.
Researchers created a “nanobody”, a small fragment of a llama antibody, that can evade human cytomegalovirus as it hides away from the immune system.
Lymph nodes are critical to the body's immune response against tumors but paradoxically, cancer cells that spread, or metastasize, to lymph nodes can often avoid being eliminated by immune cells.
Researchers used NMR techniques to determine the structure of a nanobody, facilitating a better understanding of how the protein fights against diseases.
In recent years, immunotherapy has revolutionized the field of cancer treatment. However, inflammatory reactions in healthy tissues frequently trigger side effects that can be serious and lead to the permanent discontinuation of treatment.
A typical Western high-fat diet can increase the risk of painful disorders common in people with conditions such as diabetes or obesity, according to a groundbreaking paper authored by a team led by The University of Texas Health Science Center at San Antonio, also referred to as UT Health San Antonio.
Looking for a new strategy in the long-running battle against the SARS-CoV-2 virus, researchers have developed nanobodies.
Human genetics and genomifefcs contributed $265 billion to the U.S. economy in 2019 and has the potential to drive significant further growth given major new areas of application, according to a new report issued today by the American Society of Human Genetics (ASHG).
A first-of-its-kind genetic database for autoinflammatory and autoimmune disorders has been created by Japanese researchers.
Researchers at the University of Cincinnati say a regulatory protein found in skeletal muscle fiber may play an important role in the body's fight or flight response when encountering stressful situations.
A 3D biomaterial scaffold design to slowly release stem cells has worked to ensure implanted stem cells stick around to relieve pain and reverse arthritis in mice knee joints.
Researchers within the Biomedicine Discovery Institute at Monash University have made a breakthrough in understanding the role played by high-risk immune genes associated with the development of rheumatoid arthritis (RA).
Scientists from Buck Institute have identified and are now developing an innovative, non-invasive biomarker test that could help quantify and track the performance of senolytics—a class of drugs that selectively destroy senescent cells.
TARM1 is a receptor protein, whose function in the working of the immune system is not known yet. Now, in a new research work, Japanese researchers have analyzed mouse models to investigate the promising role of TARM1 protein in the pathogenesis of rheumatoid arthritis.