Many people start to feel pain and stiffness in their bodies over time. Sometimes their hands or knees or shoulders get sore and are hard to move and may become swollen. These people may have arthritis. Arthritis may be caused by inflammation of the tissue lining the joints. Some signs of inflammation include redness, heat, pain, and swelling. These problems are telling you that something is wrong. Joints are places where two bones meet, such as your elbow or knee. Over time, in some types of arthritis but not in all, the joints involved can become severely damaged. There are different types of arthritis. In some diseases in which arthritis occurs, other organs, such as your eyes, your chest, or your skin, can also be affected. Some people may worry that arthritis means they won’t be able to work or take care of their children and their family. Others think that you just have to accept things like arthritis.
After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of "good" microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases.
Researchers have uncovered multiple new genes and genetic pathways that could lead to repurposing hundreds of existing drugs for osteoarthritis, the most common form of arthritis.
COVID-19 infection has been associated with an increased risk of autoimmune disorders, such as rheumatoid arthritis and type 1 diabetes.
An international team of researchers led by the University of California San Diego has developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.
Scientists have revealed the secret to the structural integrity of tiny particles that transport cargo from cell to cell through blood vessels and bodily fluids: special proteins that keep their membranes intact as they negotiate shifting electrical impulses in different biological environments.
Researchers with the global Human Cell Atlas (HCA) consortium report significant progress in their quest for a better understanding of the cells of the human body in health and disease, with the publication today (20 November) of a Collection of more than 40 peer-reviewed papers in Nature and other Nature Portfolio journals.
Rheumatoid arthritis is a common disease affecting an estimated 17 million people worldwide. The disease is caused by immune cells attacking the joints and can result in pain, swelling, and damage to the cartilage and bone.
Recent advancements in monoclonal antibody engineering are reshaping disease treatment, focusing on safety, effectiveness, and addressing current medical needs.
Cytokine analysis in cancer patients reveals biomarkers for predicting immune-related adverse reactions, aiding in the management of immunotherapy side effects.
Researchers have discovered a protein that inhibits the activity of bone-forming cells (osteoblasts) by preventing their maturation during the process of migrating to bone-formation sites.
Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an estimated €20,000 per patient, per year with an overall cost to the health system of ~€544 million. Only 1 in 4 patients achieve remission and a significant proportion of patients have suboptimal responses or no response at all to current available therapies.
Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -; in a particular subset of T cells -; cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered.
The currently available proteomics strategies can be used to identify and quantify probiotic bacterial proteins.
The CavitOmiX drug discovery method, developed by the drug and enzyme discovery platform Innophore.
There are many important reasons for keeping cuts and sores clean, but new research from the Perelman School of Medicine at the University of Pennsylvania shows that a certain bug, Alcaligenes faecalis (A. faecalis), can facilitate healing of hard-to-treat wounds among people with diabetes.
Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).
In disease research, it's important to know gene expression and where in a tissue the expression is happening, but marrying the two sets of information can be challenging.
UC Santa Cruz researchers have discovered a peptide in human RNA that regulates inflammation and may provide a new path for treating diseases such as arthritis and lupus.
Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions.
When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.
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