Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.
Chaperone-mediated autophagy (CMA) is a self-eating process that occurs in embryonic stem cells.
A team of researchers have analyzed the degradation mechanism of the endoplasmic reticulum (ER) called ER-phagy.
The idea of the cell as a city is a common introduction to biology, conjuring depictions of the cell's organelles as power plants, factories, roads, libraries, warehouses and more.
Researchers at TMIMS have revealed that PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria to induce selective autophagy called mitophagy.
Burkholderia pseudomallei is a bacterium in the soil that causes melioidosis, a tropical disease with high morbidity and mortality.
Cellular waste disposal, where autophagy and lysosomes interact, performs elementary functions, such as degrading damaged protein molecules, which impair cellular function, and reintroducing the resulting building blocks such as amino acids into the metabolic system.
Scientists from the Immanuel Kant Baltic Federal University and National University of Science and Technology "MISiS" have studied how magnet nanoparticles affect cancer cells in the human liver.
Korea Brain Research Institute (KBRI, headed by Suh Pann-ghill) announced on the 11th that the research team led by Dr. Mun Ji-young revealed the mechanism of autism induced by an imbalance of human gut microorganisms.
Glaucoma, a serious eye condition responsible for causing vision loss, affects over three million Americans.
Researchers at Karolinska Institutet in Sweden have discovered that excessive degradation of the power plants of our cells plays an important role in the onset of mitochondrial disease in children.
A study led by the Institut de Neurociències describes a new strategy to tackle cancer, based on inducing a potent stress in tumor causing cell destruction by autophagy.
Korea Brain Research Institute (KBRI headed by Suh Pann-ghill) announced on the 2nd that the joint research team of KBRI (team led by Dr. Mun Ji-young), Seoul National University, and Pohang University of Science and Technology discovered the proteins that engage in the formation of MAM, which is the cellular signaling hub.
As modern life-styles and high-calorie diets drive the UK's obesity levels up, researchers from the University of Warwick have found how cells respond to fasting and activate the process called autophagy, which means a healthier lifestyle can be promoted to help people maintain a healthy body weight.
Scientists from the Quadram Institute and Earlham Institute have developed a unique tool that is helping them to translate the complex communication that takes place between the body and the microbiome.
In Germany about 18 million people suffer from non-alcoholic fatty liver. The causes of this disease are manifold and include environmental as well as genetic factors.
Autophagy can be described as a housekeeping process using which cells eliminate dysfunctional contents to stabilize the energy sources during stressful situations.
Pancreatic cancer cells use a normal waste removal process to hide tags on their surfaces that would otherwise let the immune system destroy them, a new study finds. Published online April 22 in Nature, the study results help to answer a longstanding question: why are pancreatic cancers so resistant to immunotherapies, which use the body's own immune defenses to fight cancer?