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The human brain is the center of the human nervous system and is a highly complex organ. Enclosed in the cranium, it has the same general structure as the brains of other mammals, but is over three times as large as the brain of a typical mammal with an equivalent body size.

UChicago scientists shed light on the longstanding puzzle of RNA methylation

University of Chicago scientists have discovered a new wrinkle in our understanding of how our genes work.

14 Feb 2023

Rare disease involving speech and motor coordination difficulties identified

Scientists from the National Institutes of Health recently identified a new neurological condition characterized by issues with motor coordination and speech. Their observations were published in the journal npj Genomic Medicine.

From National Human Genome Research Institute (NHGRI) 13 Feb 2023

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Individuals with cocaine use disorder exhibit gene expression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.

13 Feb 2023

Prolonged alcohol use and its detrimental effects on blood protein snapshot

Jon Jacobs, a biochemist, has examined the blood of people suffering from diseases including Ebola, cancer, TB, hepatitis, diabetes, Lyme disease, brain damage, and influenza.

10 Feb 2023

Genetic variants that increase the risk of ADHD identified

Why are some people diagnosed with ADHD while others are not? And when is the seed of ADHD sown, in life or the womb?

10 Feb 2023

Large-scale differentiation of iPSC-derived motor neurons from ALS patients

A new Cedars-Sinai study in collaboration with the University of California, Irvine (UCI) and the Answer ALS consortium has examined the expression of thousands of genes in stem cell generated motor neurons that are known to die in patients with amyotrophic lateral sclerosis, a fatal neurological disorder known as ALS or Lou Gehrig's disease.

10 Feb 2023

Protein-rich droplets in cells linked to many unresolved diseases

Most proteins localize to distinct protein-rich droplets in cells, also known as "cellular condensates". Such proteins contain sequence features that function as address labels, telling the protein which condensate to move into.

9 Feb 2023

Technology development could help expand usefulness of Raman microscopy

Researchers have developed a Raman microscope that can acquire information hundreds of times faster than a conventional Raman microscope.

8 Feb 2023

Synthetic biosensor could lead to better understanding of cell biology

A synthetic biosensor that mimics properties found in cell membranes and provides an electronic readout of activity could lead to a better understanding of cell biology, development of new drugs, and the creation of sensory organs on a chip capable of detecting chemicals, similar to how noses and tongues work.

8 Feb 2023

Unraveling the mystery of massive neural network models

Large language models like OpenAI's GPT-3 are massive neural networks that can generate human-like text, from poetry to programming code.

8 Feb 2023

The brain prepares skilled movements by 'zipping and unzipping' information

The human brain prepares skilled movements such as playing the piano, competing in athletics, or dancing by 'zipping and unzipping' information about the timing and order of movements ahead of the action being performed, a new study reveals.

7 Feb 2023

Employing molecular anchor for more effective CAR immunotherapies

Researchers at St. Jude Children’s Research Hospital discovered that immune cells with the attached protein boosted the killing of cancer, irrespective of the kind of cancer cell or the type of cancer being targeted.

3 Feb 2023

Scientists unravel the physics of a cellular process linked to aggregation diseases

Researchers from Princeton University have uncovered the physics of a cellular process linked to aggregation diseases including Huntington's disease, paving the way to a deeper understanding of neurodegenerative disorders at the molecular level.

3 Feb 2023

Losartan prevents immunotherapy-related edema, improves survival in glioblastoma mouse models

Patients with glioblastoma-;the deadliest type of primary brain tumor-;may potentially benefit from immunotherapy medications called immune checkpoint inhibitors that stimulate an immune response against cancer cells.

3 Feb 2023

Microbiome therapeutic linked to quality of life improvement in patients with recurrent C. diff infection

Kevin Garey, professor of pharmacy practice and translational research at the University of Houston College of Pharmacy is reporting the first well-controlled study to demonstrate that a microbiome therapeutic, SER-109, is associated with significant quality of life improvement in patients with the debilitating recurrent infection and disease caused by Clostridium difficile (or C. diff).

1 Feb 2023

Nearly two million-euro ERC Consolidator Grant supports research on fruit fly's locomotion

When we try walking in a straight line with our eyes closed, after a few steps forward we inevitably deviate from our intended path.

1 Feb 2023

Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

A genetic mutation in the SPTSSA gene is identified as the cause of Hereditary Spastic Paraplegia, a rare disease that causes progressive weakness, stiffness and spasticity in the lower extremities, according to a study, "SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia," published in Brain on on Jan. 30.

1 Feb 2023

Brain News and Research

UChicago scientists shed light on the longstanding puzzle of RNA methylation

Rare disease involving speech and motor coordination difficulties identified

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Prolonged alcohol use and its detrimental effects on blood protein snapshot

Genetic variants that increase the risk of ADHD identified

Large-scale differentiation of iPSC-derived motor neurons from ALS patients

Protein-rich droplets in cells linked to many unresolved diseases

Technology development could help expand usefulness of Raman microscopy

Synthetic biosensor could lead to better understanding of cell biology

Unraveling the mystery of massive neural network models

The brain prepares skilled movements by 'zipping and unzipping' information

Employing molecular anchor for more effective CAR immunotherapies

Scientists unravel the physics of a cellular process linked to aggregation diseases

Losartan prevents immunotherapy-related edema, improves survival in glioblastoma mouse models

Microbiome therapeutic linked to quality of life improvement in patients with recurrent C. diff infection

Nearly two million-euro ERC Consolidator Grant supports research on fruit fly's locomotion

Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

Research supports the safety and efficacy of COVID-19 vaccination in cancer patients receiving immunotherapy

Cochlear organoids provide a platform to understand sensorineural hearing loss

Deep learning model can accurately predict the growth of deadly brain tumors

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