The lipid-exchanged, anatomically rigid, imaging/immunostaining compatible, tissue hydrogel (CLARITY) method was initially designed in 2013 by Chung and Deisseroth at the Stanford University School of Medicine. Using this process, post-mortem organs can be labeled for proteins and nucleic acids, enabling analysis of intact samples to create detailed 3D images.
Cyanobacteria are a key species in Earth's history, as they introduced atmospheric oxygen for the first time. The analysis of their evolution therefore provides important insights into the formation of modern aerobic ecosystems.
A new study led by scientists at the American Museum of Natural History, Brooklyn College, and the Catalan Institute of Paleontology Miquel Crusafont has reconstructed the well-preserved but damaged skull of a great ape species that lived about 12 million years ago.
Despite being an essential developmental process, the understanding of human embryonic genome activation is limited, owing to the lack of in vitro cell models and ethical concerns.
A new study suggests rough surfaces inspired by the bacteria-killing spikes on insect wings may be more effective at combatting drug-resistant superbugs, including fungus, than previously understood.
High-brilliance X-Rays from BESSY II can be utilized to create microscopic images with a spatial resolution of as little as a few tens of nanometers. Without the complicated sample preparation required for electron microscopy, whole cell volumes can be analyzed.
The finding, made with the use of the Advanced Photon Source, shows a new way to exploit monoclonal antibodies to subvert the "shield" of the virus, potentially paving the way for new therapies.
In order to more fully understand how diseases arise in the brain, scientists must unravel the intricate way neurons relay messages (either chemical or electrical) along a complex web of nerve cells. One way is by using a tool called DREADDs, which stands for Designer Receptors Activated by Designer Drugs.
The surging popularity of beneficial fermented foods like kombucha and yogurt is being met with a patchwork of regulations worldwide, according to a recent review.
The use of machine learning to do blood cell counts for illness detection rather than costly and often less reliable cell analyzer devices has proven labor-intensive, as the training of the machine learning model requires a tremendous amount of manual annotation activity by humans.
Proteins are among the most significant and diverse biomolecules found in living organisms. These strings of amino acids, which take on complex 3-dimensional structures, are required for tissue growth and maintenance, the activation of thousands of biochemical events, and the immune system’s defense against invaders.
Bile acids made by the liver have long been known for their critical role in helping to absorb the food we ingest.
Citrus is a significant and economically beneficial horticultural crop with nucellar polyembryony, which prevents hybrid offspring from being produced. Citrus is produced mostly through asexual methods like grafting and cuttings.
In the first study of its kind to explore caffeine's effects on dynamic visual skills, researchers concluded that caffeine increases alertness and detection accuracy for moving targets. Caffeine also improved participants' reaction times.
A new analysis adds to evidence that nutritious diets are often more environmentally sustainable, while also demonstrating the feasibility of evaluating diet sustainability at the scale of specific foods-;rather than broader food-group categories.
In the late 1600s, the Dutch tradesman Anthoni van Leeuwenhoek began investigating the world of the very small using the first microscope, discovering a riotous world of protists, bacteria, and other previously unseen organisms.
A group of scientists identified that a prevailing drug for treating constipation might boost an individual’s capability to think with better clarity.
Researchers discovered evidence that CTCF governs chromatin accessibility, the mechanism of opening tightly spooled DNA facilitating gene expression.
We are collectively failing to conserve the world's biodiversity and to mobilize natural solutions to help curb global warming. A new study carried out by the Nature Map Consortium, shows that managing a strategically placed 30% of land for conservation could safeguard 70% of all considered terrestrial plant and vertebrate animal species, while simultaneously conserving more than 62% of the world's above and below ground vulnerable carbon, and 68% of all clean water.
A new study achieved the highest-ever resolution imaging of an infectious prion, offering atomic-level data of how these abnormal proteins assemble.
Chemokines are small proteins that adhere to these chemokine receptors and regulate the behavior and movement of white blood cells.