Cas9 News and Research

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Study may provide a therapeutically safer strategy for gene editing

The CRISPR gene editing system is a robust tool specifically developed for the targeted editing of genomes. While this tool has considerable therapeutic potential, it is associated with improper editing of “off-target” sites.

13 Jul 2020

Single-nucleus RNA sequencing helps compare transcriptional responses to acute cocaine

The lab of Jeremy Day, Ph.D., at the University of Alabama at Birmingham, has used single-nucleus RNA sequencing approaches to compare transcriptional responses to acute cocaine in 16 unique cell populations from a portion of the brain called the nucleus accumbens, or NAc.

From University of Alabama 10 Jul 2020

Researchers discover protein involved in protecting B cells

Whenever a germ gets into the human body, the immune system usually responds immediately to fight off the enemy attacker. One of our defense system's most important strategies involves B lymphocytes, also known as B cells, which produce antibodies that target and neutralize pathogens.

2 Jul 2020

Researchers develop a series of APOBEC-Cas9 fusion-induced deletion systems

Many small regulatory elements, including miRNAs, miRNA binding sites, and cis-acting elements, comprise only 5~24 nucleotides and play important roles in regulating gene expression, transcription and translation, and protein structure, and thus are promising targets for gene function studies and crop improvement.

1 Jul 2020

Deep-learning-based computational models predict the activities of SpCas9 variants

Specific sequences of DNA are typically cut using CRISPR-Cas9 that has become one of the most effective and convenient biotechnology tools today.

29 Jun 2020

New system of gene editing allows for targeted, super-fast DNA repair

In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

18 Jun 2020

Study shows how viruses evade antiviral defenses

According to a new study, researchers have identified a novel antiviral defense system that can possibly be used for treating several viral infections.

17 Jun 2020

Human stem cell models reveal neurodegeneration in glaucoma

Glaucoma, a serious eye condition responsible for causing vision loss, affects over three million Americans.

12 Jun 2020

Overactive enzyme causes an inherited form of hypertension

A Turkish family from a village near the Black Sea first caught the attention of medical researchers in the early 1970s.

12 Jun 2020

RDP1 gene regulates the production of pollen grains

An international study has discovered a gene in the plant model Arabidopsis that reduces the number of pollen grains.

9 Jun 2020

New technique restores hearing in mice with a recessive genetic mutation

Using a new genetic engineering technique, known as base editing, researchers from Boston Children's Hospital and the Broad Institute of MIT and Harvard, have restored hearing in mice with a known recessive genetic mutation.

5 Jun 2020

Study identifies gene responsible for eye loss in cavefish

Mexican cavefish spend their entire lives in the dark. With no need for vision, many of them lost functional eyes.

3 Jun 2020

Recombineering technique may overcome barriers in bacterial engineering

Genetic engineering of bacteria has transformed contemporary medicine, from bacterial-based insulin to a deeper insight into infectious diseases.

From Harvard Medical School 1 Jun 2020

New CRISPR-Cas9 based method for directed protein evolution

"Directed evolution" is the process by which scientists produce tailor-made proteins for cell biology, physiology and biomedicine in the laboratory.

28 May 2020

Using CRISPR/Cas molecular scissors to recombine entire chromosomes

The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants.

27 May 2020

Scientists develop a new way to reactivate silenced genes

All cells in an organism are known to have the same genetic data but not all carry out the same function. This is because all the cells do not contain the same active genes.

19 May 2020

Biosynthetic capacity allows cancer stem cells to contribute to tumor growth

Tumors are not a consistent cluster of cells. In fact, colon cancers carry differentiated-like cells, just like the functional cells of the intestinal wall and pluripotent cells—the supposed tumor stem cells.

13 May 2020

Researchers use CRISPR/Cas9 to search for Alzheimer's-related genes

Experts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "molecular scissors" of CRISPR/Cas9 to search for new genes related to the neurodegenerative disease.

22 Apr 2020

Novel protein facilitates a critical event in mammalian fertilization

Fertilization is a fundamental process in sexual reproduction when the combination of male and female gametes blends genetic material to create a new unique individual. Now, researchers from Japan have identified a new factor that may help orchestrate this vitally complex life event.

From Osaka University 17 Apr 2020

Study clears potential obstacle to using gene drive strategy to control mosquitoes

New research from entomologists at UC Davis clears a potential obstacle to using CRISPR-Cas9 "gene drive" technology to control mosquito-borne diseases such as malaria, dengue fever, yellow fever and Zika.

From The University of California, Davis 17 Apr 2020