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Novel Genes Could Serve as Predictive Biomarkers for PARP Inhibitor Response in Prostate Cancer

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

5 Apr 2023

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

31 Mar 2023

Harnessing a natural bacterial system to deliver proteins in mice and human cells

Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals.

30 Mar 2023

New nanoparticles can perform gene editing in the lungs, paving the way for inhalable therapies

Nanoparticles can be used to deliver messenger RNA encoding proteins to the lungs, results of a new study carried out at MIT and the University of Massachusetts Medical School show.

From Massachusetts Institute of Technology (MIT) 30 Mar 2023

Genetic welding: Evolutionary meddling with genes

With CRISPR-Cas9 technology, humans can now rapidly change the evolutionary course of animals or plants by inserting genes that can easily spread through entire populations.

29 Mar 2023

Study provides a feasible tool to evaluate vesicular endocytosis of NPC1L1-cargos and cholesterol absorption

Excessive cholesterol absorption from intestinal lumen contributes to the pathogenesis of hypercholesterolemia, which is a well-established risk factor for atherosclerotic cardiovascular disease.

29 Mar 2023

Evolution driven by genetic engineering should be known as ‘genetic welding’ to draw scientific and ethical scrutiny

In an opinion paper, evolutionary geneticist Asher Cutter highlights the importance of coining the term ‘genetic welding’ for the anthropogenic manipulation of genetic drive made possible by tools such as CRISPR-Cas9.

29 Mar 2023

Potential therapeutic target in KRAS-mutant pancreatic cancer identified

A new research paper was published in Genes & Cancer on March 10, 2023, entitled, "VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer."

27 Mar 2023

Potential approach to improve solid tumor T cell therapy

Researchers at the Perelman School of Medicine at the University of Pennsylvania have been working on a preclinical study that focuses on a new strategy that uses a “one-two punch” to assist T cells in attacking solid tumors.

17 Mar 2023

Highly sensitive bioluminescent platform for nucleic acid detection

Despite significant advances, numerous highly sensitive viral disease diagnostic tests even now require complex techniques to prepare a sample or decipher a result, making them inconvenient for point-of-care settings or areas with limited resources.

17 Mar 2023

Novel platform identifies genes that control biologic processes

Inflammatory neurological diseases, such as multiple sclerosis (MS), can arise when cell-to-cell communication between cells in the central nervous system (CNS) goes awry. But exactly how this cellular crosstalk leads to the molecular changes that drive disease remain unknown.

13 Mar 2023

A reliable way to downregulate gene translation in plants

By carefully constructing upstream open reading frames (uORFs), Caixia Gao’s team at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) has created a new technique for downregulating gene translation to a predictable and desirable level in plants.

10 Mar 2023

Cas9 News and Research

Novel Genes Could Serve as Predictive Biomarkers for PARP Inhibitor Response in Prostate Cancer

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Harnessing a natural bacterial system to deliver proteins in mice and human cells

New nanoparticles can perform gene editing in the lungs, paving the way for inhalable therapies

Genetic welding: Evolutionary meddling with genes

Study provides a feasible tool to evaluate vesicular endocytosis of NPC1L1-cargos and cholesterol absorption

Evolution driven by genetic engineering should be known as ‘genetic welding’ to draw scientific and ethical scrutiny

Potential therapeutic target in KRAS-mutant pancreatic cancer identified

Potential approach to improve solid tumor T cell therapy

Highly sensitive bioluminescent platform for nucleic acid detection

Novel platform identifies genes that control biologic processes

A reliable way to downregulate gene translation in plants

New insights into the underlying mechanism that causes arrhythmogenic cardiomyopathy

CRISPR/Cas method could help save rice crops threatened by climate change

Improved efficacy of advanced genome editing with machine learning

Scientists correct limb length in mouse model of autosomal dominant Robinow Syndrome

Engineering a phage's DNA by introducing modified CRISPR-Cas machinery genes

Gaining insights into human disease biology through CRISPR platforms

Experimental optimization of prime editing to achieve high efficiency

Researchers establish and characterize a stable iPSC line for modeling human disease

The Exclusome, A New Mammalian "Containter"

Breaking Down the Onso System: PacBio's Genomic Advancement

The Last Piece of Our Genome: Sequencing the Y Chromosome

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