Chemokine News and Research

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Chemokines are a family of small cytokines, or proteins secreted by cells. Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape.

Researchers Reveal Evolutionary Origin of Mysterious Immune System Molecule in Humans

Biological systems can behave as siblings in several ways, including by borrowing something and never giving it back.

31 Jan 2024

Unveiling the Role of Exosomes in Regulating Hepatic Lipid Metabolism

Non-alcoholic fatty liver disease (NAFLD), characterized by an excess accumulation of hepatic lipids, is highly prevalent and can progress to cirrhosis and liver cancer.

12 Dec 2023

Immune Cell Movement Influenced By Water and Ion Influx

Scientists at the Francis Crick Institute, in collaboration with Imperial College London, King’s College London, and the University of Cambridge, have demonstrated that the influx of water and ions into immune cells enables them to navigate to specific locations in the body.

7 Dec 2023

Study Identifies Significant Changes in Peptides During Pyroglutamination

Peptides are biomolecules formed when two or more amino acids that perform key functions in the human organism, such as hormones, neurotransmitters, painkillers and antibiotics, bind together. For this reason, they are much studied and used by the pharmaceutical industry, for example.

2 Nov 2023

Immune Cells Can Create Their Own Chemical Cues to Navigate

In a breakthrough finding, Jonna Alanko, a researcher from InFLAMES, has unveiled that immune cells are not mere passive followers of chemical signals in their surroundings.

7 Sep 2023

T Cells Infiltrate Brain and Worsen Alzheimer's Pathology, Study Finds

Cognitive decline associated with Alzheimer's disease (AD) develops when neurons begin to die, which can be caused by inappropriate immune responses and excessive inflammation in the brain triggered by amyloid beta deposits and tau tangles, two hallmarks of the disease.

28 Aug 2023

Abnormal Immune Activity in Astrocytes Causes Dementia-Related Cognitive Deficits

People with dementia have protein build-up in astrocytes that may trigger abnormal antiviral activity and memory loss, according to a preclinical study by a team of Weill Cornell Medicine investigators.

21 Apr 2023

“Bacterial suicide squad” recruits and activates innate and adaptive antitumor immune responses

Combining discoveries in cancer immunology with sophisticated genetic engineering, Columbia University researchers have created a sort of "bacterial suicide squad" that targets tumors, attracting the host's own immune cells to the cancer to destroy it. The new work, published today in Science Advances, marks a major step forward in efforts to enlist non-pathogenic bacteria to combat cancer.

9 Mar 2023

Herpesvirus infection boosts host cellular immunity: Study

A new editorial was published in Genes & Cancer on January 19th, 2023, entitled, "Severe herpesvirus infection beats adult T-cell leukemia/lymphoma."

27 Feb 2023

Antibiotics deplete intestinal flora and weaken the immune response

According to a recent study conducted by scientists at Emory University in Atlanta, the administration of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive type of skin cancer, expedited their metastatic bone growth.

12 Sep 2022

Macrophages show altered inflammatory, metabolic expression months after mild COVID-19

There is a lack of understanding as to why some people suffer from long-lasting symptoms after COVID-19 infection.

15 Mar 2022

Novel immune deactivation pathway offers a promising therapeutic approach for cancers

Our immune systems have the potential to find and destroy cancer cells. But cancer cells can be clever and develop tricks to evade the immune system.

17 Feb 2022

Moving cell groups push forward as they form organs, become cancerous and spread

Cells push and pull on surrounding tissue to move in groups as they form organs in an embryo, track down invading bacteria, and become cancerous and spread.

From New York University (NYU) 15 Feb 2022

Study identifies new gene that promotes progression to type 1 diabetes

When the pro-inflammatory pair, a receptor called CCR2 and its ligand CCL-2, get together, it increases the risk of developing type 1 diabetes, scientists report.

17 Nov 2021

Study uncovers key factors immune cells need to survive in the battle against cancer

A study headed by scientists at Massachusetts General Hospital unravels certain crucial factors required for the survival of immune cells in the fight against cancer.

12 Aug 2021

Study decodes the activation mechanism of immune cells

Chemokines are small proteins that adhere to these chemokine receptors and regulate the behavior and movement of white blood cells.

17 Jun 2021

Study reveals urine protein biomarkers of bladder cancer

Oncotarget published "Urine protein biomarkers of bladder cancer arising from 16-plex antibody-based screens" which reported that the current study examines urine samples from 66 subjects, comprising of 31 Urology clinic controls and 35 bladder cancer patients, using a Luminex based screening platform.

24 May 2021

Triple-negative breast cancer's ecosystem reveals potential therapeutic targets

Researchers from the Garvan Institute of Medical Research have uncovered four new subtypes of cells within triple-negative breast cancer, which contain promising new therapeutic targets for the aggressive disease.

13 Aug 2020

Imaging mass spectrometry identifies tumor markers for head and neck squamous cell carcinoma

Volume 11, Issue 28 of Oncotarget features "Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry" by Schmidt et. al. which reported that the authors used MALDI imaging mass spectrometry and immunohistochemistry to seek tumor-specific expression of proteins and lipids in HNSCC samples.

15 Jul 2020

New LI383 molecule can help treat opioid-related disorders

A novel molecule LIH383 developed by scientists at the Luxembourg Institute of Health binds to and inhibits a formerly unknown opioid receptor in the brain.

22 Jun 2020