Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.
A team of researchers at Sweden’s Karolinska Institutet studied how specific immune cells known as innate lymphoid cells (ILCs), which play a role in inflammatory bowel disease (IBD), evolve into mature cells.
Mutations in the APC gene cause the production of intestinal polyps in persons suffering from familial adenomatous polyposis, a genetic disease that predisposes them to colon cancer.
There are many proteins involved in the spread of cancer. However, some of them are notably difficult to observe in patient tissue samples.
One of the most important and difficult aspects of a forensic examination is identifying the cause of death.
Some gut bacteria have a spooky superpower: they can reanimate dormant viruses lurking within other microbes.
In recent years, tumor immunotherapy has emerged as a highly promising and much-touted oncological approach.
A metabolic enzyme that has been studied in cancer biology and is important for T cell function may offer a new target for anti-inflammatory therapeutics, Vanderbilt researchers have discovered.
Recent research identified that a single sulfatase adds to the degradation of mucus that safeguards the intestinal lining.
Recent research states that the occurrence of colorectal cancer is increased by a high-fat diet.
A high-fat diet disrupts the biology of the gut's inner lining and its microbial communities -; and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.
Scientists and faculty of Vanderbilt University are in search of the “Achilles’ heel” of cancer cells that survive initial chemotherapy.
The Families SHARE workbook was developed by researchers at the NHGRI, which is part of the National Institutes of Health (NIH).
For decades, physicians and dieticians have urged people to limit their intake of high fat foods, citing links to poor health outcomes and some of the leading causes of death in the U.S., such as diabetes, heart disease and cancer.
Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cancer cells in the body. It is a systemic treatment where drugs travel throughout the body and destroy cancer cells that have spread (metastasized) to parts of the body far away from the original (primary) tumour.
Researchers have discovered how a portion of a protein communicates with a cell’s membrane to control crucial intercellular communications.
According to a study, DNA defects in the energy “factories” of a cell increase the chance of survival in patients suffering from bowel cancer.
Researchers have explained mechanisms that play a role in maintaining the embryonic stem cells in the most optimized state for use in regenerative medicine.
Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.
A study headed by UCM reports that polymorphisms in gene TGFB1 and low plasma levels of protein TGFB1 serve as biomarkers for the gastric adenocarcinoma prognosis.
A machine learning algorithm helps accurately differentiate benign and premalignant colorectal polyps on CT colonography scans, according to a study published in the journal Radiology.