Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.
Research in recent years has demonstrated the diverse roles that gut bacteria can play in health and disease, but what about contributions from viruses, which, like bacteria, perpetually reside within the human intestine?
Bile acids made by the liver have long been known for their critical role in helping to absorb the food we ingest.
Around 500,000 people in the UK live with Inflammatory Bowel Disease (IBD), a life-long, chronic condition characterized by sporadic bouts of gut inflammation causing debilitating symptoms.
An international team led by the Case Western Reserve University School of Medicine has discovered novel properties of the protein Gasdermin B that promotes repair of cells lining the gastrointestinal tract in people with chronic inflammatory disorders like Crohn's disease and ulcerative colitis.
Microplastics -; tiny pieces of plastic less than 5 mm in length –– are everywhere, from bottled water to food to air. According to recent estimates, people consume tens of thousands of these particles each year, with unknown health consequences.
New data from a research team at Friedrich-Alexander-Universität Erlangen-Nürnberg shows how inflammatory reactions can be resolved by changes to the metabolism of macrophages.
In recent years, scientists have developed monoclonal antibodies -; proteins that mimic the body's own immune defenses -; that can combat a variety of diseases, including some cancers and autoimmune disorders such as Crohn's disease.
People with Crohn's disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects.
A study has revealed how chemicals surrounding tumors, the tumor microenvironment, undermine the immune system and allow cancer to resist attack.
A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.
For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond.
A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease.
A Rutgers study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role.
Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children's Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression.
Severe ulcerative colitis - a form of inflammatory bowel disease (IBD) - has been linked to a newly-discovered strain of oral bacteria, a study led by UNSW Sydney has found.
The results obtained are encouraging and the researchers could make headway in a multifunctional cell therapy system to treat inflammatory bowel disease.
Scientists from King's College London have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated.
Several thousand strains of bacteria live in the human gut. Some of these are associated with disease, while others have beneficial effects on human health.
In a new study, researchers have compared diseased colon with healthy tissue to better understand how inflammatory bowel disease (IBD) is linked to an increased risk of colorectal cancers, at a molecular level.
In the face of a multipronged front to drive blood pressure up, including a high-salt diet, females are better able to keep their pressure down by increasing levels of a T cell that selectively dials back inflammation, scientists say.