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Atomic force spectroscopy probes cellular biomechanics in response to drugs in hypoxia

Oncotarget published "Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy" which reported that by exploiting single-cell, force spectroscopy methods, the authors probed biophysical and biomechanical kinetics of brain, breast, prostate, and pancreatic cancer cells with standard chemotherapeutic drugs in normoxia and hypoxia over 12-24 hours.

20 Jul 2021

Researchers use body-on-a-chip cancer models to study personalized immunotherapy response

Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.

20 Jul 2021

New study identifies two genetic regions linked to cluster headache

Scientists have performed the largest-ever study seeking genetic markers for cluster headache.

16 Jul 2021

$Microcrystal electron diffraction could help obtain potential pharmaceutical structures$

Microcrystal electron diffraction could help obtain potential pharmaceutical structures

In the process of drug development, solving structures of potential therapeutics with X-ray diffraction (XRD) has been a presumed, critical step so far.

16 Jul 2021

AMSBIO launches new range of biosimilar antibodies for research use

AMSBIO has launched a new range of research grade biosimilars that enable analysis of biological processes without the need to purchase expensive therapeutic-grade biologics.

From AMS Biotechnology 15 Jul 2021

Researchers develop novel technique to control tiny water droplets in lab-on-a-chip applications

Scientists develop a method to better manipulate tiny droplets in lab-on-a-chip applications for biochemistry, cell culturing, and drug screening.

12 Jul 2021

New screening method allows identification of drugs that glue proteins together

Scientists developed a new screening method that tests the effectiveness of therapeutic molecules developed to “glue” proteins together in the body.

9 Jul 2021

Emerging variants of COVID-19 could be treated with a new anticoagulant drug

The capacity of the COVID-19 virus’s spikes to bind to human cells may be hampered by molecules from the same family as the anticoagulant medication heparin.

9 Jul 2021

Study reveals how fine-tuning the immune system can improve vaccines, reduce disease severity

Immunologists have discovered a molecular route that regulates how crucial immune cells evolve into the immune system’s functioning components.

9 Jul 2021

Universal stem cells exhibit the potential for more cost-effective cell therapy

Researchers have demonstrated that gene-edited cellular treatments can effectively treat cardiovascular and pulmonary disorders.

8 Jul 2021

Lipidomics study reveals schizophrenic patients’ resistance to antipsychotic drugs

Scientists discovered 22 lipids in the blood plasma of schizophrenia patients that were linked to slower symptom improvement over time.

8 Jul 2021

Combating drug-resistant pathogens using genetically modified immune cells

As part of the drive to support junior research groups in research into infectious diseases, the Federal Ministry of Education and Research is to provide 2,162,188 euros in funding from 2021 to 2026 for the research project 'AGEnTS - Genetic Engineering of T-cells for Treating Infectious Diseases' at Friedrich-Alexander University Erlangen-Nürnberg (FAU).

7 Jul 2021

New method yields 10 times more accessible details of gene activity in individual cells

Researchers have devised a way to multiply by more than ten-fold the accessible details of gene activity in individual cells. It's a big leap in the effort to understand cancer development, brain function, immunity and other biological processes driven by the complex interactions of multitudes of different cell types.

7 Jul 2021

Drugs News and Research

Atomic force spectroscopy probes cellular biomechanics in response to drugs in hypoxia

Researchers use body-on-a-chip cancer models to study personalized immunotherapy response

New study identifies two genetic regions linked to cluster headache

Microcrystal electron diffraction could help obtain potential pharmaceutical structures

AMSBIO launches new range of biosimilar antibodies for research use

Researchers develop novel technique to control tiny water droplets in lab-on-a-chip applications

New screening method allows identification of drugs that glue proteins together

Emerging variants of COVID-19 could be treated with a new anticoagulant drug

Study reveals how fine-tuning the immune system can improve vaccines, reduce disease severity

Universal stem cells exhibit the potential for more cost-effective cell therapy

Lipidomics study reveals schizophrenic patients’ resistance to antipsychotic drugs

Combating drug-resistant pathogens using genetically modified immune cells

New method yields 10 times more accessible details of gene activity in individual cells

Scientists are paving the way for cancer treatments with fewer side effects

Experimental model reveals the protective role of antioxidants in neurodegenerative disorders

Determining class A drug use from a single fingerprint

Genetic treatment may provide a new approach to addressing obsessive-compulsive disorder (OCD)

Higher density mediates receptor activation in immune cells

Mayo Clinic researchers examine potential new CAR-T cell treatment for multiple myeloma

WEHI partners with Boehringer Ingelheim to develop novel anti-cancer therapeutics

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

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