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Gene-based blood test may predict treatment success in people with metastatic melanoma

A test that monitors blood levels of DNA fragments released by dying tumor cells may serve as an accurate early indicator of treatment success in people in late stages of one of the most aggressive forms of skin cancer, a new study finds.

From New York University (NYU) 15 Feb 2021

Study reveals the structure of heat shock proteins that could treat Huntington's disease

In Huntington's disease, a faulty protein aggregates in brain cells and eventually kills them. Such protein aggregates could, in principle, be prevented with a heat shock protein.

15 Feb 2021

Researchers identify protein sequences that might be used by SARS-CoV-2 to infect cells

Researchers at EMBL Heidelberg have identified sequences in human proteins that might be used by SARS-CoV-2 to infect cells. They have discovered that the virus might hijack certain cellular processes, and they discuss potentially relevant drugs for treating COVID-19.

12 Feb 2021

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumor neuroblastoma can be disrupted at a key point causing tumor cell death.

12 Feb 2021

Scientists identify mystery protein that explains the origins of Parkinson's Disease

Researchers have made a “vital step” toward inferring the origins of Parkinson’s disease—a neurological condition that is rapidly growing in the world.

11 Feb 2021

An outlook on latest trends in peptide drug discovery and development

Currently, there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis.

11 Feb 2021

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond.

11 Feb 2021

Scientists use new approach to avert drug resistance in glioblastomas

In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.

11 Feb 2021

New simplified approach for producing pharmaceutical substances

Tetrahydroisoquinolines (THIQ) are organic compounds, whose structure includes a benzene ring merged with a nitrogen-containing cycle.

11 Feb 2021

New therapeutic approach to restore the effectiveness of immune cells

Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique (INRS) has identified a therapeutic approach to restore the effectiveness of immune cells.

10 Feb 2021

New protein quality control system could enhance full-length translation in bacteria

Professor Sang Woo’s research group has designed a synthetic protein quality control system to improve the full-length translation in bacteria.

9 Feb 2021

New platform may accelerate genomic medicine research, drug therapies

A research team, headed by Cleveland Clinic, has designed a novel personalized genomic medicine platform that would help speed up genomic medicine studies as well as genome-informed drug discovery. The results of the new study have been recently published in the Genome Biology journal.

9 Feb 2021

$1.8 million NIH grant supports research on extracellular vesicles

Scientists have known for decades that our cells constantly shed tiny pieces known as extracellular vesicles (EVs), but until relatively recently they believed that this process was merely a way for cells to rid themselves of material that was no longer needed.

8 Feb 2021

Detecting the levels of antibiotics in food

In this interview, AZoLifeSciences speaks to Dr. Yujie Ben about her latest research that investigated the varying levels of antibiotics found in food.

From Southern University of Science and Technology 8 Feb 2021

AI analyzes tissue scans to identify cancer patients at risk of hyperprogressive disease

Researchers at Case Western Reserve University, using artificial intelligence (AI) to analyze simple tissue scans, say they have discovered biomarkers that could tell doctors which lung cancer patients might actually get worse from immunotherapy.

5 Feb 2021

Fecal microbiota transplant helps cancer patients respond to immunotherapy

For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines--known as the gut microbiome--through the use of a stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests.

From National Cancer Institute (NCI) 5 Feb 2021

Drugs News and Research

Gene-based blood test may predict treatment success in people with metastatic melanoma

Study reveals the structure of heat shock proteins that could treat Huntington's disease

Researchers identify protein sequences that might be used by SARS-CoV-2 to infect cells

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

Scientists identify mystery protein that explains the origins of Parkinson's Disease

An outlook on latest trends in peptide drug discovery and development

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

Scientists use new approach to avert drug resistance in glioblastomas

New simplified approach for producing pharmaceutical substances

New therapeutic approach to restore the effectiveness of immune cells

New protein quality control system could enhance full-length translation in bacteria

New platform may accelerate genomic medicine research, drug therapies

$1.8 million NIH grant supports research on extracellular vesicles

Detecting the levels of antibiotics in food

AI analyzes tissue scans to identify cancer patients at risk of hyperprogressive disease

Fecal microbiota transplant helps cancer patients respond to immunotherapy

Scientists determine biological mechanism that may lead to more efficient antibiotics

Study provides a causal link between the Alzheimer's risk gene and COVID-19

Scientists identify new drug target for treating Hutchinson-Gilford progeria syndrome

Advances in cancer research can expand effectiveness of immunotherapy

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