Exhaustion News and Research

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Vaccinating against certain cancer proteins can boost overall immune response and shrink tumors

Over the past decade, scientists have been exploring vaccination as a way to help fight cancer. These experimental cancer vaccines are designed to stimulate the body's own immune system to destroy a tumor, by injecting fragments of cancer proteins found on the tumor.

17 Sep 2021

Loss of natural HIV control preceded by functional impairment of T cells

HIV is a master of evading the immune system, using a variety of methods to prevent the body from being able to find and kill it.

13 Sep 2021

Stem-like T cells found in certain lymph nodes could be natural cancer fighters

Researchers performed a new study and demonstrated that stem-like T cells found in some lymph nodes could exhibit natural cancer-fighting properties.

7 Sep 2021

New study could prevent T cell exhaustion in the immune system’s fight against cancer

Struggling against a tumor is not a sprint. It is a marathon. The race of cancer-fighting T cells is at times simply very long, and the T cells give up fighting. This phenomenon is referred to as T cell exhaustion by researchers.

21 Jul 2021

Therapy using artificial metalloenzymes helps reduce tumor growth, finds study

A new study has shown that it is viable to reduce tumor growth by a therapy that involves tagging cancer cells with various therapeutic molecules.

26 Apr 2021

Study shows how WAVE2 protein maintains the immune system balance

Sinai Health researchers have reported that they have uncovered a new mechanism that regulates harmful overreactions in the body’s immune system.

26 Mar 2021

Mitigating the negative impacts of artificial light at night on wildlife

Artificial light at night (ALAN) is a major factor in global insect decline. In a paper published today in Insect Conservation and Diversity, Smithsonian Conservation Biology Institute (SCBI) scientists and partners found that using amber-colored filters to remove the blue spectra of light from "warm white" LED (light-emitting diode) lamps drastically reduces insect attraction to nocturnal lighting in a tropical forest.

18 Mar 2021

Study sheds light on how T cells specialize to combat pathogens

Scientists from the University of Basel have gained insights into the specialization of T cells.

11 Mar 2021

Animal model yields important insights into T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

15 Feb 2021

Study shows major differences in mild versus severe COVID-19 infection

These days, a crucial question on people’s minds is how long does SARS-CoV-2 immunity last after infection?

22 Jan 2021

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020