Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

NSU Research Unlocks How Bacteria "Work Together" to Exacerbate Infections

"Know thy self; know thy enemy" - Sun Tzu. That quote is from centuries ago, but it is applicable in so many ways.

9 May 2023

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.

8 May 2023

Modulation of ERK Signaling Could be Used to Stimulate Regeneration

Why do some animals regenerate lost tissues after injury while others don't? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question.

26 Apr 2023

Researchers Reveal Dual Nature of Beneficial Bacteria UD1022

Alfalfa, also known in Latin as Medicago sativa, is an agricultural crop that is part of the legume family. It is known as a protein-rich food source for dairy cattle that is easily digested and can lead to increased milk production.

19 Apr 2023

Small Vesicles Originating From Intestinal Bacteria Have an Adverse Effect on the Liver

Researchers from Niigata University and Kyoto Prefectural University have revealed that small vesicles, around 100 nm in size, released by intestinal bacteria induce immune activation and progression of liver cirrhosis, as well as reduction of serum albumin level, subsequently leading to edema and ascites.

19 Apr 2023

The Implications of Biological Clock on Lung Health

The body’s biological clock is interfered with by abnormal sleep habits, such as those of night shift workers, which have been connected to lung health problems.

18 Apr 2023

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors' location.

13 Apr 2023

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates -; bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests.

11 Apr 2023

The Role of Siglec-14 Receptors on Human Macrophages in CNT Recognition in Humans

Carbon nanotubes (CNTs) are novel nanomaterials with potential uses in a variety of sectors. However, the harm they represent to people is unknown, and studies have revealed that multiwalled CNTs cause an immune response in mice.

7 Apr 2023

Study Paves the Way to Targeted Treatments for Stargardt Disease

A recent study in the Journal of Biological Chemistry revealed the key to a protein that commonly causes blindness.

5 Apr 2023

Surface Structure Impacts Quorum Signaling of Bacteria Across Biofilms

Similar to how cells within human tissues communicate and function together as a whole, bacteria are also able to communicate with each other through chemical signals, a behavior known as quorum signaling (QS).

5 Apr 2023

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

31 Mar 2023

Previously unknown telomere and cancer connection to the immune system revealed

Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may upend long-held scientific dogma and settle conflicting studies about how and whether short telomeres contribute to cancer risk.

31 Mar 2023

Clearance of senescent cells by boosting anti-viral immune response

Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

31 Mar 2023

New nanoparticles can perform gene editing in the lungs, paving the way for inhalable therapies

Nanoparticles can be used to deliver messenger RNA encoding proteins to the lungs, results of a new study carried out at MIT and the University of Massachusetts Medical School show.

From Massachusetts Institute of Technology (MIT) 30 Mar 2023

Single mechanosensitive protein shown to contribute to fibrosis in multiple organs

Researchers from Kyushu University have found how a single mechanosensitive protein induces the process that thickens and scars tissue, known as fibrosis. The protein, called VGLL3, was shown to contribute to fibrosis in multiple organs.

23 Mar 2023

Researchers discover how specific mutation in a bacterium results in phage resistance

As antibacterial resistance continues to render obsolete the use of some antibiotics, some have turned to bacteria-killing viruses to treat acute infections as well as some chronic illnesses.

7 Mar 2023

Regulatory T cells produced in the gut play a role in repairing injured muscles

The human immune system is incredibly versatile. Among its most skilled multitaskers are T cells, known for their role in everything from fighting infection to reining in inflammation to killing nascent tumors.

3 Mar 2023

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Insilico Medicine, a clinical-stage biotech company powered by generative AI, today announces that China National Medical Products Administration (NMPA) has approved the Investigational New Drug (IND) application for ISM3312, an orally available 3CLpro inhibitor generated and designed with the support of Insilico's proprietary generative chemistry platform Chemistry42 for the treatment of COVID-19.

24 Feb 2023

Study illuminates how lung cells protect themselves against RNA viral infection

A new University of California, Irvine-led study uncovers how a protein, APOBEC3B, could protect cells against many different types of RNA viruses like respiratory syncytial virus (RSV), SARS-CoV2, influenza virus, poliovirus and measles, helping to prevent disease.

23 Feb 2023

Fibrosis News and Research

NSU Research Unlocks How Bacteria "Work Together" to Exacerbate Infections

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

Modulation of ERK Signaling Could be Used to Stimulate Regeneration

Researchers Reveal Dual Nature of Beneficial Bacteria UD1022

Small Vesicles Originating From Intestinal Bacteria Have an Adverse Effect on the Liver

The Implications of Biological Clock on Lung Health

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

The Role of Siglec-14 Receptors on Human Macrophages in CNT Recognition in Humans

Study Paves the Way to Targeted Treatments for Stargardt Disease

Surface Structure Impacts Quorum Signaling of Bacteria Across Biofilms

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Previously unknown telomere and cancer connection to the immune system revealed

Clearance of senescent cells by boosting anti-viral immune response

New nanoparticles can perform gene editing in the lungs, paving the way for inhalable therapies

Single mechanosensitive protein shown to contribute to fibrosis in multiple organs

Researchers discover how specific mutation in a bacterium results in phage resistance

Regulatory T cells produced in the gut play a role in repairing injured muscles

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Study illuminates how lung cells protect themselves against RNA viral infection

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

Latest in Genomics