Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Improved efficacy of advanced genome editing with machine learning

Researchers at the Wellcome Sanger Institute have developed a new tool to estimate the probability of successfully introducing a gene-edited DNA sequence into a cell’s genome using the prime editing method.

17 Feb 2023

A protein in the lung forms a natural protective barrier against SARS-CoV-2 infection

University of Sydney scientists have discovered a protein in the lung that blocks SARS-CoV-2 infection and forms a natural protective barrier in the human body.

10 Feb 2023

Experimental optimization of prime editing to achieve high efficiency

Genome editing technologies have enormous potential for treating genetic diseases. Techniques like the extensively used CRISPR/Cas9 gene scissors target the source of the disease directly in the DNA.

3 Feb 2023

Gene editing made faster than ever before using AI

The first simple production of customizable proteins known as zinc fingers to treat diseases by turning genes on and off might be enabled with the help of an artificial intelligence (AI) program.

From New York University (NYU) 27 Jan 2023

New genetic condition that raises vulnerability to opportunistic infections

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including life-threatening fungal pneumonia.

24 Jan 2023

Newly developed tool helps snip out faulty genes in a safe manner

Scientists from the Massachusetts Institute of Technology (MIT) have come up with a new tool that has the potential to detach faulty genes and exchange them with new ones in a highly safe and effective way.

From Massachusetts Institute of Technology (MIT) 25 Nov 2022

A remarkable finding reorients attempts to cure liver disease

A long-running debate in gastroenterology has been settled by WEHI researchers who have shown that prevalent liver diseases are not caused by inflammatory cell death as previously believed.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 7 Oct 2022

Novel model system to identify new treatments for CF patients who continue to struggle without therapies

A mutation in the CFTR gene results in cystic fibrosis (CF). Despite the fact that there are many hundreds of identified mutations, not all of them can now be treated, leaving a sizable portion of CF patients without access to targeted medicines.

3 Aug 2022

Scientists discover cells travel faster through mucus than blood

Some cells travel quicker in thicker fluids, such as honey against water or mucus versus blood, because their ruffled edges detect the viscosity of their surroundings and adjust to boost their speed.

From University of Toronto 28 Jul 2022

Research highlights the new genetic variations and pediatric NAFLD severity

A multidisciplinary group of researchers at the University of California San Diego School of Medicine have advanced investigations into the genetic causes of NAFLD in children.

1 Jul 2022

Study reveals genetic architecture of COVID-19 risk factors and disease complications

According to a recent study of information from the Veterans Affairs Million Veteran Program, there are genetic correlations between COVID-19 severity and specific medical disorders that are established risk factors for severe COVID-19.

3 May 2022

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

First product within new ‘in-a-box’ range, which harnesses next-generation, human-relevant Liver-on-a-Chip technology to improve the accuracy and efficiency of NASH drug discovery.

From CN Bio Innovations Limited 26 Apr 2022

New protective mechanism against non-alcoholic fatty liver disease identified

Non-alcoholic fatty liver disease (NAFLD), commonly known as fatty liver disease, is a prevalent disease frequently seen in obese people. Having high fat content in the liver is detrimental as it is strongly associated with severe health problems like diabetes, high blood pressure, and liver cancer.

20 Apr 2022

A new rule book for the design of therapeutic cells with improved specificity and safety

Therapies based on engineered immune cells have recently emerged as a promising approach in the treatment of cancer.

18 Apr 2022

Scientists discover a special cell in salivary glands that is likely crucial for oral health

Scientists at Scripps Research and the National Institute of Dental and Craniofacial Research have discovered a special type of cell that resides in salivary glands and is likely crucial for oral health.

13 Apr 2022

Certain RNA molecules may serve as markers of cellular stress in different diseases

The body's ability to respond to various types of stress is essential for maintaining health, and failure of such adaptive stress responses can trigger or worsen numerous diseases.

6 Apr 2022

Globins in the body help fight liver disease

Anti-fibrotic therapy is still a medical necessity in the treatment of chronic liver disease in humans. The anti-fibrotic activity of globin family members in hepatic stellate cells (HSCs), the principal cell type involved in liver fibrosis, was reported by a research group led by Professor Norifumi Kawada of Osaka Metropolitan University (OMU).

24 Mar 2022

Proteins surrounding organs and tissues switch off natural killer cells’ “killer” function, study finds

Natural killer (NK) cells, which are part of the body’s innate, or first-line, immune response, interact with tumor cells, viral infections, and solid organ transplants, according to a new study.

21 Mar 2022

Cellular therapy leads to meaningful functional improvements in DMD patients

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

From The University of California, Davis 14 Mar 2022

CNIC study uncovers a nuclear import mechanism essential for organ growth and development

Scientists at the Centro Nacional de Investigaciones Cardiovasculares have identified a nuclear import mechanism essential for organ growth and development. Manipulation of this mechanism has potential applications in the control of organ growth and organ regeneration.

4 Mar 2022