GPCR News and Research

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Adhesion GPCR Mayo Plays Key Role in Midgut Development of Fruit Flies

Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling the cardiovascular system and more.

18 Mar 2024

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

26 Dec 2023

Novel Biosensors Uncover Brain Activity

Researchers have employed novel biosensors to uncover neuropeptide activity in the brain, introducing innovative tools for examining the release, function, and regulation of these vital signaling molecules in vivo.

17 Nov 2023

New, Improved Dual Version of Living Yeast Biosensor to Detect All Peptide Variants

Biosensors-;sensors that can detect biological samples-;are powerful tools for understanding the function, composition, and structure of biochemical molecules.

26 Apr 2023

Understanding the Functioning of Opioid Receptors at Unprecedented Spatial Resolution

The human body naturally produces opioid-like substances, such as endorphins, which block the perception of pain and increase the feeling of well-being.

20 Apr 2023

Uncovering the role of the third intracellular loop in the GPCR’s signaling mechanism

Over a one-third of FDA-approved drugs tend to function by targeting a G protein-coupled receptor, or so-called GPCR. The human body consists of over 800 kinds of GPCRs that offer cells with data concerning the external surrounding to calibrate responses.

20 Mar 2023

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR. The human body has more than 800 types of GPCRs that provide cells with information about the external environment to calibrate responses.

20 Mar 2023

Study shows how G protein-coupled receptors signal helps drug development

G protein-coupled receptors (GPCRs), membrane proteins that are the target of one-third of approved drugs, are being studied by scientists at St. Jude Children’s Research Hospital and Columbia University/New York State Psychiatric Institute.

29 Apr 2022

Immune cells in arteries can sniff out their surroundings and cause inflammation

An artery is not like a nose. Or is it? Scientists at La Jolla Institute for Immunology (LJI) have discovered that immune cells in arteries can "sniff" out their surroundings and cause inflammation.

17 Jan 2022

HKU researchers develop new drug discovery strategy targeting membrane proteins on live cells

A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.

29 Dec 2020

Study offers explanation to why people respond differently to the same drug

Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.

5 Oct 2020

Researchers create an algorithm that predicts allosteric sites in proteins

A new technology that uses a protein's structure to predict the inner wiring that controls the protein's function and dynamics is now available for scientists to utilize.

4 Sep 2020

Study offers promising data for improved treatments for cardiac disease

A group of researchers have recently published an article that provides promising data for enhanced therapeutic treatments for cardiac disease.

20 Aug 2020

Molecular dynamic simulations may contribute to structure-based drug design

Uppsala University scientists have reported that they have developed a new way to predict how unique molecules that can be employed in novel immunotherapy.

26 Jun 2020

Synthetic molecule suppresses drug cravings with fewer side effects

A new synthetic molecule selectively reduces the physiological rewards of cocaine in mice.

1 Jun 2020

What If We Could Design Powerful Drugs Without Unwanted Side Effects?

Psychedelics have proven effective in treating depression and PTSD, but the medical use of these drugs is limited by their hallucinations.

22 May 2020

Scientists elucidate precise shape of a key player in human metabolism

A USC-led international team of scientists has found the precise shape of a key player in human metabolism, which could lead the way to better treatments for obesity and other metabolic disease.

24 Apr 2020

Study offers detailed molecular map of interaction patterns of GPCR and different G protein subtypes

G protein-coupled receptors (GPCRs) have crucial roles to play in cell signal transduction and can be used as vital therapeutic targets for several diseases.

20 Mar 2020