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Potential therapeutic target in KRAS-mutant pancreatic cancer identified

A new research paper was published in Genes & Cancer on March 10, 2023, entitled, "VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer."

27 Mar 2023

Heart-healthy benefits of walnuts may be linked to beneficial changes in the mix of gut microbes

A new study examining the gene expression of gut microbes suggests that the heart-healthy benefits of walnuts may be linked to beneficial changes in the mix of microbes found in our gut.

27 Mar 2023

Meta-scale approach to quantifying the protein variants in the human body

A key conundrum in biology is why many very simple creatures, such as the widely studied worm C. elegans, have almost as many genes as the human genome, which has about 20,000 genes.

27 Mar 2023

Immune system’s aptitude in reducing reliance on antibiotics for treating infections

The removal of obsolete and damaged cell components by the body is crucial for fighting diseases like tuberculosis (TB), which establish themselves inside human cells, according to researchers from the Francis Crick Institute.

27 Mar 2023

Analyzing how the global regulation factor reshapes the cell-fate-decision landscape

Genes and their regulatory relationships form complex networks that govern cell differentiation trajectories. However, predicting and understanding cell fate decisions using bottom-up network topology is still side-lined.

27 Mar 2023

New findings could help target the causes of aging and cancer development

A protein complex prevents the repair of genome damage in human cells, in mice and in the nematode Caenorhabditis elegans, a team of researchers at the University of Cologne has discovered.

24 Mar 2023

Eye color genes play important roles in maintaining retinal health

Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products.

24 Mar 2023

Walnuts might support heart health by changing the gut microbiome

Scientists at Texas Tech University have revealed that the heart-healthy benefits of eating walnuts could be a result of the changes they induce in the gut microbiome.

24 Mar 2023

Immunity adaptation found in genomes of Stone Age farmers

New research suggests that diversity in genes implicated in immunity might have facilitated the shift from hunter-gatherer lifestyles to agriculture that occurred in prehistoric Europe over the course of around 1,500 years.

23 Mar 2023

Single mechanosensitive protein shown to contribute to fibrosis in multiple organs

Researchers from Kyushu University have found how a single mechanosensitive protein induces the process that thickens and scars tissue, known as fibrosis. The protein, called VGLL3, was shown to contribute to fibrosis in multiple organs.

23 Mar 2023

Blunted inflammatory response in obese individuals responsible for susceptibility to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

23 Mar 2023

Variations in methylation linked to age in the human sperm epigenome

A higher risk of reproductive and child health issues is linked to advanced paternal age. Increasing evidence points to age-related alterations in the sperm epigenome as one underlying cause.

23 Mar 2023

Identifying the underlying causes of rare genetic immune disorders

The activated PI3K Delta syndrome 2 (APDS2) is a rare genetic disease that is caused by cellular anomalies, according to experts from the Garvan Institute of Medical Research.

23 Mar 2023

Study identifies 238 amyloid toxicity protective or activator genes

An international study led by the Molecular Physiology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) identifies new genes that modulate the toxicity of the protein β-amyloid, responsible for causing Alzheimer's disease.

22 Mar 2023

CABBI/GLBRC researchers peer into the complexities of life on a leaf

"Have you ever wondered about life on a leaf?" Great Lakes Bioenergy Research Center (GLBRC) researcher Ashley Shade asks a simple question, but it's one well worth investigation.

22 Mar 2023

Novel low oxygen signaling pathway discovered in the Arabidopsis plant

Aerobic reactions are essential to sustain plant growth and development. Impaired oxygen availability due to excessive water availability, e.g., during waterlogging or flooding, reduces plant productivity and survival.

22 Mar 2023

Genetic signature might be shared across multiple substance use disorders, new study reveals

A new study has revealed a common genetic signature that seems to underlie multiple substance use disorders.

22 Mar 2023

Key Hox genes control stem cells involved in bone formation and repair

A new study discovered that genes that have long been known to regulate bone formation before birth also govern bone healing later in life.

From New York University (NYU) 21 Mar 2023

New study pinpoints key source of T cell "exhaustion"

Custom-made to attack cancer cells, CAR T-cell therapies have opened a new era in the treatment of human cancers, particularly, in hematologic malignancies.

21 Mar 2023

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

21 Mar 2023

Genes News and Research

Potential therapeutic target in KRAS-mutant pancreatic cancer identified

Heart-healthy benefits of walnuts may be linked to beneficial changes in the mix of gut microbes

Meta-scale approach to quantifying the protein variants in the human body

Immune system’s aptitude in reducing reliance on antibiotics for treating infections

Analyzing how the global regulation factor reshapes the cell-fate-decision landscape

New findings could help target the causes of aging and cancer development

Eye color genes play important roles in maintaining retinal health

Walnuts might support heart health by changing the gut microbiome

Immunity adaptation found in genomes of Stone Age farmers

Single mechanosensitive protein shown to contribute to fibrosis in multiple organs

Blunted inflammatory response in obese individuals responsible for susceptibility to severe COVID-19

Variations in methylation linked to age in the human sperm epigenome

Identifying the underlying causes of rare genetic immune disorders

Study identifies 238 amyloid toxicity protective or activator genes

CABBI/GLBRC researchers peer into the complexities of life on a leaf

Novel low oxygen signaling pathway discovered in the Arabidopsis plant

Genetic signature might be shared across multiple substance use disorders, new study reveals

Key Hox genes control stem cells involved in bone formation and repair

New study pinpoints key source of T cell "exhaustion"

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

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