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Novel protein degradation technology provides functional insights into how CTCF regulates transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription.

30 Jan 2023

Cryo-EM helps visualize the detailed structure of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

30 Jan 2023

Accumulation of collagen at injured sites in the gut stimulates cellular reprogramming, study reveals

Most cells have a pretty normal life: they're born, they grow, they get old, and they die. But the Benjamin Buttons of the cellular world can go from old to young again in the right context.

30 Jan 2023

Newly discovered genetic mutation may be a root cause of severe cases of childhood glaucoma

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families and can rob children of their vision by 3 years of age.

30 Jan 2023

Evolution of mint plants' chemistry could lead to new medicines, pesticides

The mint family of herbs, which includes sage, rosemary, basil, and even woody plants like teak, offers an invigorating jolt to our senses of smell and taste.

27 Jan 2023

Scientists receive $10 million from HHMI for research on using viruses as therapeutic agents

Taking a bold step into a new era of biology, a team of scientists from the University of California San Diego, the J. Craig Venter Institute and Yale University has been awarded $10 million by the Howard Hughes Medical Institute to support research on using viruses as new therapeutic agents.

27 Jan 2023

Deep-learning model for zinc finger design allows reprogramming of human transcription factors

Researchers at the University of Toronto and New York University have developed a novel technology that can engineer proteins to target any stretch of DNA in the human genome, opening a door toward gene therapies for a broader range of health conditions.

27 Jan 2023

Gene editing made faster than ever before using AI

The first simple production of customizable proteins known as zinc fingers to treat diseases by turning genes on and off might be enabled with the help of an artificial intelligence (AI) program.

From New York University (NYU) 27 Jan 2023

MicroRNA’s influence on lupus disease inflammation

Researchers from Nagoya University’s Graduate School of Medicine in Japan have uncovered how microRNA (miRNA) affects inflammation in mice with lupus. They discovered two downregulated miRNAs in the disease along with a rare circumstance where several miRNAs control the same set of genes.

27 Jan 2023

Researchers discover new transporter for recycling of bacterial cell wall

A transporter which some bacteria use to recycle fragments of their cell wall has been discovered by researchers at Umeå University, Sweden.

27 Jan 2023

The 12-hour cyclic gene activity abnormalities in schizophrenic brains

The first proof of 12-hour cycles of gene activity in the human brain is presented by researchers at the University of Pittsburgh School of Medicine in the United States.

From University of Pittsburgh 26 Jan 2023

Figuring out how cells safeguard their genomes during replication

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome, a cell’s complete set of DNA, is most vulnerable while it is being duplicated before a cell divides.

26 Jan 2023

Enhancing the efficacy of CRISPR/Cas9 and related methods

The effectiveness of molecular genetic techniques like CRISPR/Cas9 and related systems has been significantly improved, and their range of applications has been expanded, by researchers from the Department of Developmental Biology/Physiology at the Centre for Organismal Studies of Heidelberg University.

26 Jan 2023

Study sheds new light on a lifestyle switch that occurs in marine bacteria

Scientists have detailed a lifestyle switch that occurs in marine bacteria, where they change from coexisting with algae hosts in a mutually beneficial interaction to suddenly killing them.

25 Jan 2023

Researchers use supercomputer to unveil new methods for DNA mosaic recognition

As humans, we each have trillions of cells. And each cell has a nucleus with individual genetic information –DNA – that can mutate to create an abnormality.

25 Jan 2023

New genetic condition that raises vulnerability to opportunistic infections

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including life-threatening fungal pneumonia.

24 Jan 2023