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The mechanism behind fruit fly germ cells forming ring canals

Cell division is the process through which the majority of cells in the bodies of living beings duplicate their contents and physically split into new cells.

10 Mar 2023

Insights into the role of the germline in de novo mutation

The male reproductive system is a hotspot for the introduction of new genes. Perhaps that might assist in understanding why fathers tend to pass on more new mutations than mothers do. However, it does not explain why older fathers pass on more mutations than younger fathers.

16 Jan 2023

Point-of-care program boosts genetic testing for prostate cancer

Certain prostate cancer patients have genetic mutations that could affect how they are treated. According to a study published in Urology Practice®, an Official Journal of the American Urological Association (AUA), a comprehensive, on-site genetic testing program developed by urologists could help close the gap for this underutilized resource.

16 Dec 2022

Revealing cancer development in people carrying inherited BRCA1 mutations

Researchers from Weill Cornell Medicine have discovered that people who inherit a mutant copy of the BRCA1 gene may develop mutations and cancer due to error-prone DNA replication and repair.

16 Nov 2022

Scientists demonstrate a potential new route for the generation of genetic diversity in corals

In a discovery that challenges over a century of evolutionary conventional wisdom, corals have been shown to pass somatic mutations – changes to the DNA sequence that occur in non-reproductive cells – to their offspring.

From Penn State University 1 Sep 2022

Zbtb38 removal results in early embryonic death

DNA methylation is a critical epigenetic alteration for mammalian development.

20 Apr 2022

Primordial germ cell-like cells produced from stem cells undergo gametogenesis to yield normal offspring

Primordial germ cell-like cells (PGCLCs), generated in vitro from the stem cells of rats, undergo gametogenesis in vivo and yield normal rat offspring, a new study demonstrates.

8 Apr 2022

Researchers investigate genomic data discrepancies among racial groups

The Cancer Genome Atlas, one of the biggest cancer research databases, was used by Mayo Clinic researchers to investigate disparities in genomic data quality.

21 Mar 2022

Researchers develop a method for preserving human primordial germ cell-like cells

Human primordial germ cells (PGCs) are the early precursors of the eggs (oocytes) and sperm that are necessary to keep humankind alive and reproducing.

11 Feb 2022

Experts develop CRISPR-Cas9-mediated inheritance control in male mice

The world’s first CRISPR-Cas9 genetic editing-based strategy to regulate inheritance in mammals was declared nearly three years ago.

From UC San Diego 13 Jan 2022

Gene writing helps develop advanced therapies safely and effectively

An international, multidisciplinary team of researchers from the Translational Synthetic Biology Laboratory at Pompeu Fabra University (Barcelona, Spain), led by Dr. Marc Güell, has published an article in the scientific journal Nature Communications.

14 Dec 2021

De Novo Mutations may Play a Role in Male Infertility

In this interview, we speak to Dr. Miguel J. Xavier about his latest research into male infertility and how de novo mutations may play a part.

From Newcastle University 19 Nov 2021

CHOP-led network aims to unlock the genetic mysteries behind pediatric brain tumors

Unlocking the genetic mysteries behind pediatric brain tumors is at the heart of the mission of the Center for Data Driven Discovery in Biomedicine (D3b) at Children's Hospital of Philadelphia.

3 Nov 2021

Researchers discover the role of a retrotransposon in horizontal memory transfer in roundworms

When an organism encounters a threat in its environment, it is to the species' advantage to warn others of the peril.

6 Sep 2021

Researchers identify virus-derived variations in human genomes

Three geneticists from RIKEN identified previously undetected snippets of genetic material from viruses that were hidden in human DNA.

12 Aug 2021

Low representation of minority groups in genomic databases may impact therapy selection

Low representation of minority groups in public genomic databases may affect therapy selection for Black patients with cancer, according to new Mayo Clinic research published in npj Precision Oncology.

22 Mar 2021

Rare genetic variants contribute to increased risk for lung cancer

In the United States, lung cancer is the main cause of cancer death in both male and female populations.

19 Mar 2021

Testing for inherited genes can help understand future cancer risk in pediatric patients

Because cancers in children are rare, many details about their biology remain unknown. In the field of cancer genetics, there's a limited understanding of how inherited genetic changes may contribute to the formation and growth of tumors.

17 Feb 2021

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond.

11 Feb 2021

Glyphosate could be used as biomarkers to predict incurring diseases in future generations

Exposure to the widely used weed-killer glyphosate makes genetic changes to rats that can be linked to increased disease in their grandchildren and great-grandchildren, a new study has found.

10 Dec 2020