Gum disease or periodontal disease is an infection caused by bacteria under the gum tissue that begin to destroy the gums and bone. Teeth become loose, chewing becomes difficult, and teeth may have to be extracted. Gum disease may also be related to damage elsewhere in the body; recent studies point to associations between such oral infections and diabetes, heart disease, stroke, and preterm, low-weight births. Research is underway to further examine these connections.
Researchers from Tokyo University of Agriculture and Technology have made a novel revelation about the processes of bone loss in gum disease (periodontitis).
Researchers from Tokyo Medical and Dental University (TMDU) identify a novel mechanism by which periodontal disease may cause diabetes
Immune response is a balancing act: Too much can lead to inflammatory or autoimmune disease; too little could lead to a serious infection. Regulatory T cells, or Tregs, are important players in striking this balance, acting as "brakes" on the immune response so it doesn't go overboard.
Porphyromonas gingivalis is a major bacterial pathogen which leads to periodontitis also known as gum disease. In Japan, 80% of adults aged 35 and over suffer from this disease. What's more, P. gingivalis has also been linked to rheumatoid arthritis, cardiovascular disease, pancreatic cancer, and even Alzheimer's disease.
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