Hematology News and Research

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Hematology, also spelled haematology, is the branch of biology (physiology), pathology, clinical laboratory, internal medicine, and pediatrics that is concerned with the study of blood, the blood-forming organs, and blood diseases. Hematology includes the study of etiology, diagnosis, treatment, prognosis, and prevention of blood diseases.

Master regulator behind the development of antibody-producing cells identified

Scientists from Weill Cornell Medicine recently found the master regulator behind the development of antibody-creating cells.

27 Sep 2021

Circulating tumor cells found to form clusters that cause breast cancer metastases

A new study reports that circulating tumor cells that exhibit the features of stem cells employ ICAM1 to enable the formation of CTC clusters.

24 Sep 2021

Naturally occurring protein that blocks inflammatory response linked to better stroke recovery in mice

A naturally occurring protein that blocks an inflammatory immune response was associated with better stroke recovery in a study conducted in mice, according to preliminary research to be presented at the American Heart Association's Vascular Discovery: From Genes to Medicine Scientific Sessions 2021.

23 Sep 2021

UTHSC researcher receives grant to extend work on The Cancer Genome Atlas project

Neil Hayes, MD, MPH, director of the Center for Cancer Research at the University of Tennessee Health Science Center, is one of two principal investigators for a $1.8 million grant that extends the work of The Cancer Genome Atlas (TCGA), a groundbreaking multisite project to understand cancer at its molecular level through genome sequencing and extensive data analysis.

16 Sep 2021

Study reveals how two separate DNA changes may predict aggressive childhood leukemias

New research published today in JAMA Oncology reports how two separate DNA changes appear to predict aggressive childhood leukemias when they occur in combination.

From The University of Utah 20 Aug 2021

Researchers develop method to preserve high-quality cultured stem cells for a long time

Hematopoietic stem cells — the precursors to blood cells — have been notoriously difficult to grow in a dish, a critical tool in basic research.

16 Aug 2021

Odor-based test accurately distinguishes hard-to-detect cancers

An odor-based test that sniffs out vapors emanating from blood samples was able to distinguish between benign and pancreatic and ovarian cancer cells with up to 95 percent accuracy, according to a new study from researchers at the University of Pennsylvania and Penn's Perelman School of Medicine.

3 Jun 2021

A gene that impacts the development of bone cancer in children discovered

Researchers have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bone cancer that occurs mainly in children.

2 Jun 2021

Highly efficient method to identify the genetic “switches” that control gene expression

Scientists have created a high-throughput method to help explain and regulate gene expression for the treatment of diseases like beta-thalassemia and sickle cell disease.

7 May 2021

New AI model predicts targets for previously unmapped T cells against coronavirus

A research team has created an AI technique that can bind immune cells to their targets and uncouple the types of white blood cells that identify SARS-CoV-2.

26 Apr 2021

Small molecular changes can have dramatic impact on the CAR T cell function

When researchers from Penn Medicine found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric antigen receptor (CAR) T cell therapy targeting the CD22 antigen didn't respond, they went back to the drawing board to determine why.

23 Apr 2021

A new way to predict positive outcomes of immunotherapy in patients with bladder cancer

Researchers have detected and validated groups of genes linked to immunotherapy resistance in patients with metastatic urothelial cancer of the bladder.

12 Apr 2021

Microfluidic chip and AI-based microscope help measure hemoglobin levels

Blood count is a test that is often performed to determine the health of patients and generally involves an estimation of the concentration of hemoglobin.

24 Feb 2021

Seasonal human coronavirus antibodies not associated with protection against SARS-CoV-2

Past exposure to seasonal coronaviruses (CoVs), which cause the common cold, does not result in the production of antibodies that protect against the novel coronavirus SARS-CoV-2, according to a study led by Scott Hensley, PhD, an associate professor of Microbiology at the Perelman School of Medicine at the University of Pennsylvania.

11 Feb 2021

Scientists use new approach to avert drug resistance in glioblastomas

In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.

11 Feb 2021

New technique to improve genome editing technology

A group of scientists from Peter the Great St. Petersburg Polytechnic University (SPbPU), in association with collaborators from Belgium, has taken a step in the advancement of genome editing technologies.

3 Feb 2021

Yale scientists discover novel metabolic gatekeeper mechanism for leukemia

In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published online today in the Proceedings of the National Academy of Sciences (PNAS).

2 Feb 2021

Tumor DNA in DLBCL patient's stem cells or blood can predict risk of relapse after transplant

Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse.

8 Dec 2020

Study: CAR T cell therapy is a safe, effective therapy for high-risk large B-cell lymphoma

A study led by researchers at The University of Texas MD Anderson Cancer Center found that axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy, is a safe and effective first-line therapy for patients with high-risk large B-cell lymphoma (LBCL), a group with an urgent need for new and effective treatments.

8 Dec 2020

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Hematology News and Research

Master regulator behind the development of antibody-producing cells identified

Circulating tumor cells found to form clusters that cause breast cancer metastases

Naturally occurring protein that blocks inflammatory response linked to better stroke recovery in mice

UTHSC researcher receives grant to extend work on The Cancer Genome Atlas project

Study reveals how two separate DNA changes may predict aggressive childhood leukemias

Researchers develop method to preserve high-quality cultured stem cells for a long time

Odor-based test accurately distinguishes hard-to-detect cancers

A gene that impacts the development of bone cancer in children discovered

Highly efficient method to identify the genetic “switches” that control gene expression

New AI model predicts targets for previously unmapped T cells against coronavirus

Small molecular changes can have dramatic impact on the CAR T cell function

A new way to predict positive outcomes of immunotherapy in patients with bladder cancer

Microfluidic chip and AI-based microscope help measure hemoglobin levels

Seasonal human coronavirus antibodies not associated with protection against SARS-CoV-2

Scientists use new approach to avert drug resistance in glioblastomas

New technique to improve genome editing technology

Yale scientists discover novel metabolic gatekeeper mechanism for leukemia

Tumor DNA in DLBCL patient's stem cells or blood can predict risk of relapse after transplant

Study: CAR T cell therapy is a safe, effective therapy for high-risk large B-cell lymphoma

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

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