Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.
A group of researchers has unearthed the secrets behind a tiny but crucial protein that shuttles zinc ions (Zn2+) within our bodies. The discovery offers a deeper understanding of how our cells maintain optimal health.
In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.
Human immunodeficiency virus-1 (HIV) introduces a copy of its DNA into human immune cells as part of its life cycle. Some of these newly infected immune cells can subsequently enter an inactive, latent state for an extended length of time, which is known as HIV latency.
Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.
The activated PI3K Delta syndrome 2 (APDS2) is a rare genetic disease that is caused by cellular anomalies, according to experts from the Garvan Institute of Medical Research.
Custom-made to attack cancer cells, CAR T-cell therapies have opened a new era in the treatment of human cancers, particularly, in hematologic malignancies.
In the human body, virus particles are identified by pattern recognition receptors (PRRs) either within or on the cell surface. When a receptor is activated, a signaling cascade is initiated, which results in the production and release of signaling molecules like interferons and cytokines.
Cell division is the process through which the majority of cells in the bodies of living beings duplicate their contents and physically split into new cells.
An international study led by researchers from the Infection Biology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) establishes that one type of dendritic cells is crucial for the success of immunotherapeutic treatments to control chronic viral infections.
Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an inflammation-induced protein isoform, known as ADAR1 p150.
An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including life-threatening fungal pneumonia.
According to Duke Health researchers, the human immunodeficiency virus (HIV) appears to be driven into a latent state, lurking in cells only to erupt once more. This immune response likely evolved to help fight infections.
According to a recent study led by Andrés Finzi, a professor at the Université de Montréal and researcher at the CHUM Research Centre, the type of virus used as a model to study the effectiveness of non-neutralizing antibodies against the virus that causes AIDS, has a crucial role to play.
On actual viral next-generation sequencing data, a recent study compares and evaluates eight de novo genome assembly software tools.
An international group led by McMaster University researchers, in partnership with the University of Paris Cité, has recognized and reconfigured the first ancient genome of E. coli using fragments derived from a 16th-century mummy’s gallstone.
Infections caused by primary immunodeficiency diseases (PID) can be persistent and life-threatening. More than 450 PIDs have been identified, yet diagnosing them quickly and accurately remains a difficulty.
Researchers from Texas Biomedical Research Institute and Tulane University have created a new software device that makes analyzing genetic data about a host and its microbiome at the very same time simpler, quicker, and less expensive.
Northwestern Medicine researchers are employing recent developments in CRISPR gene-editing technology to discover novel biological method that could lead to longer-lasting treatments and new therapeutic tactics for the Human Immunodeficiency Virus (HIV).
The human immunodeficiency virus (HIV-1) particularly attacks CD4 lymphocytes, a type of white blood cell considered to be the conductor of the immune system.
Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free.