Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.
An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including life-threatening fungal pneumonia.
According to Duke Health researchers, the human immunodeficiency virus (HIV) appears to be driven into a latent state, lurking in cells only to erupt once more. This immune response likely evolved to help fight infections.
According to a recent study led by Andrés Finzi, a professor at the Université de Montréal and researcher at the CHUM Research Centre, the type of virus used as a model to study the effectiveness of non-neutralizing antibodies against the virus that causes AIDS, has a crucial role to play.
On actual viral next-generation sequencing data, a recent study compares and evaluates eight de novo genome assembly software tools.
An international group led by McMaster University researchers, in partnership with the University of Paris Cité, has recognized and reconfigured the first ancient genome of E. coli using fragments derived from a 16th-century mummy’s gallstone.
Infections caused by primary immunodeficiency diseases (PID) can be persistent and life-threatening. More than 450 PIDs have been identified, yet diagnosing them quickly and accurately remains a difficulty.
Researchers from Texas Biomedical Research Institute and Tulane University have created a new software device that makes analyzing genetic data about a host and its microbiome at the very same time simpler, quicker, and less expensive.
Northwestern Medicine researchers are employing recent developments in CRISPR gene-editing technology to discover novel biological method that could lead to longer-lasting treatments and new therapeutic tactics for the Human Immunodeficiency Virus (HIV).
The human immunodeficiency virus (HIV-1) particularly attacks CD4 lymphocytes, a type of white blood cell considered to be the conductor of the immune system.
Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free.
Three geneticists from RIKEN identified previously undetected snippets of genetic material from viruses that were hidden in human DNA.
A team of researchers from the University of California - Davis Health (UC Davis) has made a breakthrough discovery of a unique type of stem cell that reduces the amount of the virus that causes AIDS.
Type I Diabetes Mellitus, also called T1D, is an autoimmune disorder that results in an irreversible loss of insulin-producing beta-cells found in the pancreas.
A new study indicates that protein kinases, which initiate the process that erodes the body’s immunity, significantly contribute to the immunodeficiency in HIV patients. Drugs that block these protein kinases may offer a solution to treating HIV patients whose immunity is not restored by antiretroviral therapy.
Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique (INRS) has identified a therapeutic approach to restore the effectiveness of immune cells.
Researchers have revealed how a rare DNA change rebalanced the immune system of patients with a life-threatening genetic immunodeficiency.
Damien D'Amours and his team at the Ottawa Institute of Systems Biology needed three years to discover the molecular defects associated with the LIC Syndrome, a serious genetic disorder that affects young children and result in acute respiratory distress, immune deficiency and abnormal chromosomes.
Taking a major step forward in HIV research, scientists at the Lewis Katz School of Medicine at Temple University have successfully edited SIV - a virus closely related to HIV, the cause of AIDS - from the genomes of non-human primates.
The cell membrane is impermeable to viruses: to get inside and infect a cell, they use a range of strategies to exploit the cellular and biochemical properties of the membranes.
Viruses are tiny invaders that cause a wide range of diseases, from rabies to tomato spotted wilt virus and, most recently, COVID-19 in humans. But viruses can do more than elicit sickness -- and not all viruses are tiny.