Inflammatory Bowel Disease News and Research

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Inflammatory bowel disease (IBD) is an ongoing or chronic health problem that causes inflammation and swelling in the digestive tract. The irritation causes bleeding sores called ulcers to form along the digestive tract. This in turn can cause crampy, abdominal pain and severe bloody diarrhea.

Uncovering the Gut Virome's Role in Health and Disease

The human gut is home to trillions of microbes, yet scientific understanding has largely focused on bacteria, leaving the virome—the community of viruses—relatively uncharted.

4 Jul 2025

Ancient Immune Sensor STING Found to Regulate Gut Microbe Tolerance

Thousands of bacterial and other microbial species live in the human gut, supporting healthy digestion, immunity, metabolism and other functions.

18 Jun 2025

Unraveling the Genetic Roots of Anemia in Inflammatory Bowel Disease

One of the most frequent side effects of inflammatory bowel disease, or IBD, is iron deficiency and anemia, which can be made worse by a genetic mutation linked to Crohn’s disease, according to a study conducted by biomedical scientists at the University of California, Riverside School of Medicine.

9 Jun 2025

Gut Microbiome Offers Clues to Detecting and Treating Gastrointestinal Diseases

Scientists have discovered a range of 'biomarkers' that could help to improve detection and treatment of gastrointestinal diseases (GIDs) such as gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD).

29 May 2025

Study Reveals How H3K36 Methylation Controls Intestinal Cell Plasticity and Regeneration

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

26 Mar 2025

New Database Provides Insights into snoRNA Expression in Zebrafish

Small nucleolar RNAs (snoRNAs) are non-coding RNA molecules whose role in gene regulation and their association with certain diseases, such as inflammatory bowel disease (IBD) or colorectal cancer, has only recently become known.

20 Mar 2025

Synthetic Microbiome Treatment Prevents C. difficile Infection in Mice

A synthetic microbiome therapy, tested in mice, protects against severe symptoms of a gut infection that is notoriously difficult-to-treat and potentially life threatening in humans, according to a team of researchers at Penn State.

4 Mar 2025

Engineered Phages Deliver Therapeutic Proteins to Intestines

Engineered phages transform gut bacteria into drug delivery systems, releasing therapeutic proteins that reduce inflammation and promote satiety in obesity.

19 Feb 2025

Inflammasome Helps Block Malignancy in Blood Stem Cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

Study Reveals How Gut Bacteria and the Body Regulate Bile Acids

Our gut is a bustling hub of activity, home to trillions of microbes that work together with our bodies to keep us healthy.

15 Jan 2025

Stem Cells' Ability to Respond to Physical Forces Uncovered

A new study from The Hospital for Sick Children (SickKids) and Institut Curie reveals how stem cells sense and respond to their environment, with implications for inflammatory bowel disease and colorectal cancer.

4 Dec 2024

Understanding Gut Inflammation Through RNA Sequencing

This study creates a comprehensive atlas of gastrointestinal cell types, revealing how stem cell-derived INFLAREs drive inflammation in chronic diseases.

29 Nov 2024

Novel Fungal Commensal Shaping Mouse Immune Responses

Researchers from Weill Cornell Medicine have found a fungus in the stomach of mice that may provide a clue to the evolution of fungi in the gastrointestinal tract.

28 Nov 2024

Mapping of Mouse Intestine Sheds Light on Immune Control and Adaptability

The intestine maintains a delicate balance in the body, absorbing nutrients and water while maintaining a healthy relationship with the gut microbiome, but this equilibrium is disrupted in parts of the intestine in conditions such as celiac disease, ulcerative colitis, and Crohn's disease.

22 Nov 2024

Molecule Found to Aid Intestinal Healing and Prevent Tumor Growth in Colorectal Cancer

Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumor growth in colorectal cancer.

21 Nov 2024

Novel Cellular Atlas of the Human Gastrointestinal Tract

Spatial and single-cell data from 1.6 million cells have been combined to produce the most complete cell map of the human stomach to date.

21 Nov 2024

New Technology Isolates Key Gut Bacteria Linked to Disease

Researchers at UMC Utrecht have created a novel technique that effectively separates a particular subset of gut bacteria that are identified by IgA antibodies from fecal samples.

15 Nov 2024

Intricate Relationship Between Goblet Cells and the Gut Microbiome

In a new study, scientists from the University of California, San Diego have shed light on the crucial function goblet cells—specialized gut-lining cells—play in preserving a balanced and healthy immune environment in the gastrointestinal (GI) tract. Dr. Fernanda Raya Tonetti led the project, and Dr. Cristina Llorente made important contributions.

13 Nov 2024

New Insights Into the Role of p53 in Intestinal Inflammation

A group of scientists from Charité – Universitätsmedizin and the Berlin Institute for Medical Systems Biology of the Max Delbrück Center have provided fresh insight into the pathophysiology of ulcerative colitis an inflammatory bowel disease that affects an estimated five million people globally and is associated with a higher risk of colon cancer.

28 Oct 2024

A Novel Mechanism for Apoptotic Cell Removal in Epithelial Tissues

In a recent discovery, a study team from Kyushu University in Japan has shed light on how the systems defend against illness and injury by identifying a calcium-based mechanism that is essential to the removal of dead cells.

10 Oct 2024