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DeLisi's new book underscores how most crime is never known to law enforcement

In his new book, Matt DeLisi, a world-renowned criminologist at Iowa State University, lays out evidence that Ted Bundy's criminal career was far lengthier and deadlier than the official record from 1974 to 1978.

21 Mar 2023

New study pinpoints key source of T cell "exhaustion"

Custom-made to attack cancer cells, CAR T-cell therapies have opened a new era in the treatment of human cancers, particularly, in hematologic malignancies.

21 Mar 2023

Novel mechanism by which bacteria colonize the gut identified

A new mechanism by which “good” bacteria colonize the gut was unraveled by scientists at Yale University. The finding could aid spur the development of new probiotic therapies.

20 Mar 2023

Amide-to-ester substitutions can enhance the membrane permeability of cyclic hexapeptides

Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions-;as demonstrated by researchers from Tokyo Institute of Technology.

20 Mar 2023

Study presents top 100 research questions facing plant science

Without plants, we'd have no air to breathe or food to eat, yet plant science lingers in the shadowy wings while other fields take center stage.

20 Mar 2023

New antibody "cocktail" may help counter the Lassa virus

The finding, made with the use of the Advanced Photon Source, shows a new way to exploit monoclonal antibodies to subvert the "shield" of the virus, potentially paving the way for new therapies.

20 Mar 2023

Delaying paralysis in ALS by using designer DNA drug

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

20 Mar 2023

Neoadjuvant dual immunotherapy and chemotherapy improve outcomes in patients with resectable NSCLC

In a Phase II trial led by researchers from The University of Texas MD Anderson Cancer Center, adding ipilimumab to a neoadjuvant, or pre-surgical, combination of nivolumab plus platinum-based chemotherapy, resulted in a major pathologic response (MPR) in half of all treated patients with early-stage, resectable non-small cell lung cancer (NSCLC).

20 Mar 2023

Highlighting a potential sex‐specific precision immunotherapy strategy

Immunotherapy is an effective form of treatment for various types of cancer. However, its effect on pancreatic cancer is restricted and varies between men and women. Karolinska Institutet scientists have observed a possible explanation for this gender difference.

17 Mar 2023

Study reveals: Coronaviruses that cause common colds boost immune response to COVID-19

During the pandemic, it became clear that children who contracted COVID-19 became less ill than adults. One hypothesis has been that common colds would give children immunity protecting against a severe form of the disease. Researchers at Karolinska Institutet are now able to show that OC43, one of the coronaviruses that cause common colds, boosts the immune response to COVID-19. The study, which is published in PNAS, could give rise to more tailored vaccine programmes for children and adults.

16 Mar 2023

Study reveals the cellular composition and circuit organization of the locus coeruleus

A small nucleus in the brainstem called locus coeruleus (literally the "blue spot,") is the primary source of a major neuromodulator, norepinephrine (NE), an important mediator of the 'fight or flight' response in animals. However, very little is known about the local connections of this small albeit critically important group of neurons.

16 Mar 2023

Novel newborn screening test for HCU works by measuring homocysteine levels

Scientists have developed a test that could greatly improve quality of life for infants with homocystinuria (HCU)-;a congenital disease that, if not treated early, causes serious complications. Research demonstrating the efficacy of this test was published today in AACC's Clinical Chemistry journal.

16 Mar 2023

High correlation between the product of a gene in the majority of cancers

The product of a gene expressed in most cancers, including the most prevalent type of head and neck cancer, has been linked to elevated levels of white blood cells that produce antibodies inside tumors, according to researchers at the University of California San Diego School of Medicine and UC San Diego Moores Cancer Center.

14 Mar 2023

SMART researchers develop the world's first microneedle-based drug delivery technique for plants

Researchers from the Disruptive & Sustainable Technologies for Agricultural Precision (DiSTAP) Interdisciplinary Research Group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, and their collaborators from Temasek Life Sciences Laboratory (TLL) and Massachusetts Institute of Technology (MIT), have developed the first-ever microneedle-based drug delivery technique for plants.

14 Mar 2023

Analyzing the antimicrobial resistance profile of the main agent of urinary tract infections

The human intestine is an environment inhabited by many bacteria and other microorganisms collectively known as the gut microbiome, gut microbiota or intestinal flora. In most people, it contributes to wellness. A healthy gut indicates a stronger immune system, improved metabolism, and a healthy brain and heart, among other functions.

14 Mar 2023

Developing new therapies that leverage the host immune system

Yersinia bacteria cause a variety of human and animal diseases, the most notorious being the plague, caused by Yersinia pestis. A relative, Yersinia pseudotuberculosis, causes gastrointestinal illness and is less deadly but naturally infects both mice and humans, making it a useful model for studying its interactions with the immune system.

14 Mar 2023

Understanding the relationship between gut microbiome and CAR T-cell therapy response

Microorganisms live in or on almost every part of the human body and play an important role in the regulation of normal human processes. As a result, changes in the number or type of microorganisms, also known as the microbiome, can contribute to disease and altered responses to therapy, including cancer treatment.

14 Mar 2023

Study investigates schizophrenia risk across African ancestry

Researchers have identified two previously unknown genes linked to schizophrenia and newly implicated a third gene as carrying risk for both schizophrenia and autism. Led by the Icahn School of Medicine at Mount Sinai, the multi-center study further demonstrated that the schizophrenia risk conferred by these rare damaging variants is conserved across ethnicities. The study may also point to new therapeutics.

14 Mar 2023

Bacteriophages might hold the key to fighting antibiotic resistance

As conventional antibiotics continue to lose effectiveness against evolving pathogens, scientists are keen to employ the bacteria-killing techniques perfected by bacteriophages, the viruses that infect bacteria.

14 Mar 2023

Chemical compound found in common tropical plant helps kill cancer cells

A scientific instrument at the Department of Energy's Oak Ridge National Laboratory could help create a noninvasive cancer treatment derived from a common tropical plant.

13 Mar 2023

Laboratory News and Research

DeLisi's new book underscores how most crime is never known to law enforcement

New study pinpoints key source of T cell "exhaustion"

Novel mechanism by which bacteria colonize the gut identified

Amide-to-ester substitutions can enhance the membrane permeability of cyclic hexapeptides

Study presents top 100 research questions facing plant science

New antibody "cocktail" may help counter the Lassa virus

Delaying paralysis in ALS by using designer DNA drug

Neoadjuvant dual immunotherapy and chemotherapy improve outcomes in patients with resectable NSCLC

Highlighting a potential sex‐specific precision immunotherapy strategy

Study reveals: Coronaviruses that cause common colds boost immune response to COVID-19

Study reveals the cellular composition and circuit organization of the locus coeruleus

Novel newborn screening test for HCU works by measuring homocysteine levels

High correlation between the product of a gene in the majority of cancers

SMART researchers develop the world's first microneedle-based drug delivery technique for plants

Analyzing the antimicrobial resistance profile of the main agent of urinary tract infections

Developing new therapies that leverage the host immune system

Understanding the relationship between gut microbiome and CAR T-cell therapy response

Study investigates schizophrenia risk across African ancestry

Bacteriophages might hold the key to fighting antibiotic resistance

Chemical compound found in common tropical plant helps kill cancer cells

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