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Novel framework provides solutions to evade detoxification networks

Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and elimination by the cellular detoxification network regulated by the pregnane X receptor (PXR). This research provides a framework to develop solutions to the long-standing issue of how to evade detoxification networks using medicinal chemistry. The findings were published today in Proceedings of the National Academy of Sciences.

1 Mar 2023

New family of pharmaceutical compounds that target RNA

In Jennifer Hines’ lab, a group of graduate and undergraduate chemistry students recently discovered a new family of compounds that can target RNA and interfere with its function. In the future, RNA-targeted treatments to treat cancer and metabolic diseases, together with bacterial and viral infections, could be developed using the chemical scaffold found in this research.

15 Feb 2023

Using data-driven computer models to predict light emission properties of iridium-centered chemicals

More than 30 years ago, the phrase "green chemistry" emerged with the Pollution Prevention Act of 1990.

31 Jan 2023

AI-based strategy helps discover high-affinity antibody drugs

Scientists at University of California San Diego School of Medicine have developed an artificial intelligence (AI)-based strategy for discovering high-affinity antibody drugs.

31 Jan 2023

Molecular motion of “undruggable” proteins reveals drug-binding sites

“Undruggable” proteins, whose structures and roles in disease are known but who appear unable to be targeted by drugs that will bind to them, present some of the hardest problems in disease treatment.

23 Nov 2022

Georgia Tech researchers develop a new biomaterial that could cure Type 1 diabetes

Insulin injections to treat Type 1 diabetes could become a thing of the past, but finding the cure faces many challenges.

4 Nov 2022

Novel means to prevent and treat gonorrhea

According to scientists from the Georgia State University’s Institute for Biomedical Sciences, producing a mutation that impedes the way the bacterial pathogen Neisseria gonorrhoeae transmits gonorrhea might provide a novel means to prevent and treat the disease.

26 Sep 2022

Antibiotics deplete intestinal flora and weaken the immune response

According to a recent study conducted by scientists at Emory University in Atlanta, the administration of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive type of skin cancer, expedited their metastatic bone growth.

12 Sep 2022

Study shows how nanotechnology may help for structural research of RNA molecules

Humans live in a world created and managed by RNA—the genetic molecule DNA’s equally important sibling.

3 May 2022

Researchers develop an antibody as a tool for opening the blood-brain barrier

The brain is composed of billions of neurons-; vulnerable cells that require a protective environment to function properly.

17 Mar 2022

Protein appears key to the function and survival of brain cells most impacted by glaucoma

A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report.

2 Mar 2022

New device to assess water quality uses powerful and programmable genetic networks

Northwestern University synthetic biologists have developed a low-cost, easy-to-use, hand-held device that can let users know -; within mere minutes -; if their water is safe to drink.

18 Feb 2022

Study shows how natural products inhibit SARS-CoV-2 main protease Mpro

The fight against the COVID-19 pandemic is a worldwide scientific issue including the development of measures to combat the virus and its harmful effects.

From University of Barcelona 14 Feb 2022

Hemoglobin plays role as a chemosensory signal for mother mice to protect offspring

Biochemists in Japan were surprised to discover that the molecule hemoglobin in the blood works not only as an oxygen carrier, but when the blood is spilled as a result of aggression, accident or predator attack, the molecule also acts as a chemosensory signal -; a chemical stimulus picked up by the senses, namely smell in this case -; for lactating mother mice, prompting digging or rearing behavior in them to check the surrounding environment and keep their offspring safe.

11 Feb 2022

Ligand News and Research

Novel framework provides solutions to evade detoxification networks

New family of pharmaceutical compounds that target RNA

Using data-driven computer models to predict light emission properties of iridium-centered chemicals

AI-based strategy helps discover high-affinity antibody drugs

Molecular motion of “undruggable” proteins reveals drug-binding sites

Georgia Tech researchers develop a new biomaterial that could cure Type 1 diabetes

Novel means to prevent and treat gonorrhea

Antibiotics deplete intestinal flora and weaken the immune response

Study shows how nanotechnology may help for structural research of RNA molecules

Researchers develop an antibody as a tool for opening the blood-brain barrier

Protein appears key to the function and survival of brain cells most impacted by glaucoma

New device to assess water quality uses powerful and programmable genetic networks

Study shows how natural products inhibit SARS-CoV-2 main protease Mpro

Hemoglobin plays role as a chemosensory signal for mother mice to protect offspring

Novel study to identify how immune receptors recognize unique chemical signals on fungal cells

Treatment with common allergy medication linked to improved immunotherapy response

Research could help understand DCIR's role in the pathogenesis of autoimmune diseases

Study identifies new gene that promotes progression to type 1 diabetes

Gold nanoclusters could be the new weapon in the fight against bacterial antibiotic resistance

Researchers predict protein binding based on shape using fastest supercomputer

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

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