Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease that presents as aseptic meningitis (inflammation of the membrane, or meninges, that surrounds the brain and spinal cord), encephalitis (inflammation of the brain), or meningoencephalitis (inflammation of both the brain and meninges). Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae that was initially isolated in 1933. Although LCMV is most commonly recognized as causing neurological disease, as its name implies, infection without symptoms or mild febrile illnesses are common clinical manifestations. Additionally, pregnancy-related infection has been associated with congenital hydrocephalus, chorioretinitis, and mental retardation.
An international study led by researchers from the Infection Biology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) establishes that one type of dendritic cells is crucial for the success of immunotherapeutic treatments to control chronic viral infections.
Scientists from the University of Basel observed in experiments with mice that cells can self-heal and eradicate viruses.
Researchers have designed a program that allows the complete study of the SARS-CoV-2 mutant spectrum by ultrasequencing.
Viruses such as HIV, hepatitis B and hepatitis C evade or disrupt the immune system to create persistent infections.
Scientists have discovered mechanisms that cause functional deterioration of the immune system in reaction to viral infections, including COVID-19 or HIV.
Stem cells in the intestines maintain an excellent balance between two promising forms—developing into intestinal epithelial cells, or remaining as stem cells.
In the fight against cancer or chronic infections, the immune system must be active over long periods of time.
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