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Reptile Conservation Could Benefit From New Range of Cell Lines

The creation of the first wide variety of reptile cell lines is highlighted in a new scientific study that was published in the journal Microorganisms.

7 Aug 2023

RNA Modification in Driving Pancreatic Cancer Growth

RNA molecules can undergo chemical changes like m6A, which can have a significant influence on gene expression and affect several aspects of cancer development and progression

7 Aug 2023

GEMINI Test Uses Genome-Wide Sequencing to Detect Cancer

Novel blood testing technology being developed by researchers at the Johns Hopkins Kimmel Cancer Center that combines genome-wide sequencing of single molecules of DNA shed from tumors and machine learning may allow earlier detection of lung and other cancers.

7 Aug 2023

New Insights Into How T Cells Become Exhausted in Cancer

Immune system T cells that should be able to kill cancer cells become dysfunctional or "exhausted" within hours of encountering a tumor, according to a study reported Aug. 3 in Nature Immunology.

7 Aug 2023

Elephants may Hold Secrets to Long Life

Indiana University researcher Daniella Chusyd is studying human aging in an unlikely way: through elephants.

7 Aug 2023

Determining a Network of Cellular Programs Controlling Human Cancers

A Ludwig Cancer Research study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers.

4 Aug 2023

Study Shows How Sensory Neurons Control Gastrointestinal Tracts

Gastrointestinal and digestive issues impact roughly 3 million people across the United States alone, and that number is growing.

4 Aug 2023

Gut Hormone Plays a Vital Role in Maintaining the Balance of Fungi in the Digestive System of Mammals

Peptide YY (PYY), a hormone produced by gut endocrine cells that was already known to control appetite, also plays an important role in maintaining the balance of fungi in the digestive system of mammals, according to new research from the University of Chicago.

4 Aug 2023

Do Host Social Interactions Influence Gut Bacteria Evolution?

A recent study demonstrates how host social interactions can have a significant influence on the development of gut bacteria in the gut microbiome. The study, carried out by a group of researchers from Instituto Gulbenkian de Ciência, sought to investigate the impact of host-to-host bacterial transmission on Escherichia coli (E. coli) evolution in mammalian guts.

3 Aug 2023

New Breakthrough in Generative AI Models and AlphaFold Structures for Drug Discovery

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has achieved a significant breakthrough in the application of multiple generative AI models and AlphaFold structures for drug discovery.

3 Aug 2023

New Nanopore Technology Can Identify Single-Molecule Protein Variations

A group of researchers guided by the University of Oxford has made significant progress in detecting changes in protein structures. The method, which was published in Nature Nanotechnology, uses novel nanopore technology to detect structural variations at the single-molecule level, even deep within long protein chains.

2 Aug 2023

Alternate Fuel ‘Cells’ Redefines Function of Nutrition in the Immune System

A metabolic by-product that is more prominent during fasting can improve immune cells’ ability to fight off infection and disease, according to a preliminary study conducted by researchers at the Van Andel Institute and its partners.

31 Jul 2023

New Insights Into Lactate Transporters and Their Therapeutic Potential

Researchers from the Giulio Superti-Furga Lab at CeMM, the Austrian Academy of Sciences’ Research Center for Molecular Medicine, have developed a new technique for identifying specific inhibitors of a lactate transporter linked to cancer and other diseases.

31 Jul 2023

Study Provides New Insight Into the Evolutionary History of Gorillas

An international research study led by the University of Vienna (Austria) and the Institute of Evolutionary Biology (IBE) in Barcelona (Spain), recently published in the journal Nature Ecology and Evolution, provides a better insight into the evolutionary history of gorillas.

31 Jul 2023

Integrating Ultrasound with Genetics to Precisely Modify Neurons in the Brain

Researchers have developed methods to study and manipulate areas of the brain, though many of those methods are restricted by the limited depth that light can reach within the brain. A multidisciplinary team at Washington University in St. Louis plans to overcome that limitation by integrating ultrasound with genetics to precisely modify neurons in the brain.

28 Jul 2023

RNA-Based CATCH Strategy Aims to Activate Dendritic Cells

Investigators at the Icahn School of Medicine at Mount Sinai have designed an innovative RNA-based strategy to activate dendritic cells-;which play a key role in immune response-;that eradicated tumors and prevented their recurrence in mouse models of melanoma.

28 Jul 2023

Analyzing DNA Damage-Induced NF-κB Targeted by Novel Small Molecule Inhibitors

Chemotherapy and radiotherapy aim to destroy cancer cells by inducing DNA double-strand breaks – damage that, once inflicted, usually causes the cells to die. But damage to a cell's genetic material also activates a signaling pathway called IKK/NF-κB that helps prevent cell death, thus limiting the success of these treatments in patients.

28 Jul 2023

New Proof-of-Concept Model for Delivering Gene Editing Tools to Treat Blood Disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

28 Jul 2023

Nasal Swab Proves to Determine the Effectiveness of Antibiotics

According to a recent JAMA study by scientists at the University of Pittsburgh and UPMC, a nasal swab to screen for three types of bacteria can reveal whether or not antibiotics are likely to be beneficial in children with suspected sinusitis.

26 Jul 2023

Looking at Protein Function in Preventing Female Obesity

Obesity is on the rise in the US, which is linked to worse health outcomes and a lower quality of life. Over 30% of American individuals are currently considered fat. Obesity is a significant and expanding public health issue since it is a risk factor for several diseases, including diabetes, cardiovascular disease, and COVID-19.

26 Jul 2023