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Microglia Replacement Halts Progression of Fatal Neurological Disease in Mice and Humans

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset of 43 years and an average life expectancy of only 3 to 5 years after symptoms begin.

11 Jul 2025

Exercise Boosts Immune Response in Cancer Through Bacterial Metabolites

A new study from the University of Pittsburgh shows for the first time how exercise improves cancer outcomes and enhances response to immunotherapy in mice by reshaping the gut microbiome.

10 Jul 2025

New Cellular Signature Reveals Why Some Prostate Cancers Resist Standard Treatment

A new study from University of Michigan Rogel Cancer Center researchers identifies a cellular signature that explains why about one-third of prostate cancers respond especially poorly to treatment.

9 Jul 2025

New Protein Superfamily Redefines Bacterial Interactions

A newly identified bacterial protein, PopA, reveals complex interactions in bacteria, challenging existing models of membrane protein formation.

9 Jul 2025

New Insights into Cell Membrane Energy Waves

Johns Hopkins researchers identify energy-generating waves on cancer cell membranes, revealing potential targets for slowing tumor growth and spread.

9 Jul 2025

New Global Platform Aims to Standardize and Improve Single-Cell Analysis

Researchers from more than 50 international institutions have launched Open Problems (https://openproblems.bio), a collaborative open-source platform to benchmark, improve, and run competitions for computational methods in single-cell genomics.

8 Jul 2025

Cryo-EM Uncovers How Tiny Protein Enzyme Precisely Trims tRNA

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the right amino acids to ribosomes, the cell's protein-making factories.

8 Jul 2025

Reinvigorating T Cells Offers Hope for More Effective Cancer Immunotherapy

CD8⁺ T cells are the immune system's frontline warriors, charged with detecting and eliminating cancer cells. But in the hostile and chronic environment of tumors, these cells often falter.

8 Jul 2025

Scientists Discover Unique Bacterial Protein That Traps Membrane Lipids

Scientists have identified a new type of protein in bacteria that could change our understanding of how these organisms interact with their environments.

8 Jul 2025

Evidence for Neural Stem Cell-Based Therapies in Multiple Sclerosis

Research indicates that neural stem cell transplants could promote myelin repair in progressive multiple sclerosis, paving the way for innovative treatments.

8 Jul 2025

New Study Highlights Increased COVID-19 Risk for Adult Childhood Cancer Survivors

Even decades after their diagnosis, those who survived childhood cancer are more likely to get severe COVID-19.

7 Jul 2025

Iowa State Engineers Reinvent Gene Gun for Faster and Safer Crop Editing

Plant scientists have used a standard "gene gun" since 1988 to genetically modify crops for better yield, nutrition, pest resistance and other valuable traits.

5 Jul 2025

Aligned Stem Cell Sheets Show Boosted Healing Potential

A new way to grow stem cells may help them release more of the signaling proteins they use to repair tissue, potentially improving future treatments.

4 Jul 2025

Breakthrough Method Rapidly Generates Lung Repair Cells From Fibroblasts

Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse embryonic fibroblasts without using stem cell technology.

4 Jul 2025

Engineered Macrophages Enable CAR T Cells to Overcome Glioblastoma Barriers

A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the effectiveness of chimeric antigen receptor (CAR) T cell therapy against glioblastoma, one of the most lethal and treatment-resistant brain tumors.

4 Jul 2025

Uncovering the Gut Virome's Role in Health and Disease

The human gut is home to trillions of microbes, yet scientific understanding has largely focused on bacteria, leaving the virome—the community of viruses—relatively uncharted.

4 Jul 2025

Animal-Free 3D Fat-Immune Cell Model to Study Inflammation

Researchers developed a human adipocyte-macrophage co-culture model in GG hydrogels to study adipose tissue inflammation and test anti-inflammatory strategies.

3 Jul 2025

New Stem Cell Reports Perspective: Biomanufacturing in Low Earth Orbit

A new perspective article just published in Stem Cell Reports, “Biomanufacturing in low Earth orbit: A paradigm shift,” features insights from the ISS National Laboratory’s very own Program Director for In-Space Biomanufacturing Davide Marotta, Deputy Chief Scientist Donna Roberts, and Chief Scientist Michael Roberts, as well as leading researchers in regenerative medicine.

3 Jul 2025

Combining AI with Robotics and Synthetic Biology to Improve Industrial Enzymes

By combining artificial intelligence with automated robotics and synthetic biology, researchers at the University of Illinois Urbana-Champaign have dramatically improved performance of two important industrial enzymes - and created a user-friendly, fast process to improve many more.

2 Jul 2025