Metabolites News and Research

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Researchers identify a new type of PII-like proteins in Lactobacillus hilgardii LMG 7934

The team is led by Associate Professor Ayrat Kayumov (Department of Genetics, Kazan Federal University). In this research, the scientists not only performed genome sequencing, but also found a completely new type of PII-Like Protein PotN.

20 Aug 2020

Drugs designed to lower alpha-ketoglutarate levels could help fight DIPG tumors

Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures.

19 Aug 2020

Researchers develop new drugs to eradicate parasitic worms

In this breakthrough method, parasitic worms are prevented from using alternative metabolism routes offered by microbes living inside them.

12 Aug 2020

Novel molecule shown to have potential therapeutic effects for arthritis

Arthritis affects almost 2% of the world's population, or some 150 million people, and currently, there is no completely effective treatment for this chronic disease. A new molecule developed in the laboratory has been shown to have potential therapeutic effects.

12 Aug 2020

Researchers describe a previously unknown phylum of aquatic Archaea

In a publication in Nature Communications last Friday, NIOZ scientists Nina Dombrowski and Anja Spang and their collaboration partners describe a previously unknown phylum of aquatic Archaea that are likely dependent on partner organisms for growth while potentially being able to conserve some energy by fermentation.

11 Aug 2020

Genetic analysis reveals the inhibitory role of NSD2 enzyme in cellular senescence

Using a detailed genetic analysis, a research team from Japan-based Kumamoto University has discovered that the NSD2 enzyme, which controls the actions of several genes, also functions to block the aging of cells.

10 Aug 2020

Study may help identify women at risk of developing type 2 diabetes after pregnancy

Researchers have discovered that lipid metabolism is disrupted after childbirth in women suffering from gestational diabetes, who subsequently develop type 2 diabetes.

From University of Toronto 6 Aug 2020

Study uncovers molecular mechanism of metabolite-mediated epigenome involved in organismal aging

Scientists have recently demonstrated that acetyl-CoA connects mitochondrial stress to the nuclear epigenome through the NuRD complex.

4 Aug 2020

Researchers show how gut microbiomes change the nature of cancer mutations

It is a fact that has long baffled doctors: Cancer in the small intestine is quite rare, whereas colorectal cancer, a neighboring though much smaller organ, is one of the leading causes of cancer death for men and women. What is it about the colon that seems to "attract" cancer?

30 Jul 2020

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020

Boosting metabolic resources in the brain could be a way to slow neurodegeneration

Researchers at Vanderbilt University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.

From Vanderbilt University 22 Jul 2020

Environmental pollutants pose risks to finless porpoises

A new study has revealed that environmental pollutants pose toxicological risks to finless porpoises (Neophocaena asiaeorientalis).

21 Jul 2020

Study: Specific mechanism of Cyclocarya paliurus shows promise for treating type 2 diabetes

Type 1 diabetes mellitus and type 2 diabetes mellitus (T2DM) are the two main types of diabetes, while T2DM accounts for 90%-95% of those with diabetes.

14 Jul 2020

Metabolomics can help understand the impact of calorie-restricted diets on aging

Changes in a few small molecules involved in a cell's metabolism seem to indicate whether a restricted "life extension" diet will actually extend, shorten, or have no effect on lifespan, a study of fruit flies has found.

10 Jul 2020

Researchers solve a controversial question in photosynthesis

The research team has devised novel approaches to observe energy changes that occur in subcellular compartments in live plants.

1 Jul 2020

Pseudotargeted metabolomics method can help analyze bile and amino acids

A team of researchers has come up with a procedure through which the pseudotargeted metabolomics technique can be systematically summarized and upgraded.

29 Jun 2020

Researchers discover unknown enzyme activity towards human endogenous substrates

Scientists have identified an enzymatic activity towards common drugs as well as significant human endogenous substrates, that was previously not known.

24 Jun 2020

Five-minute urine test measures quality of people's diets

Scientists have completed large-scale tests on a new type of five-minute urine test that measures the health of a person's diet, and produces an individual's unique urine 'fingerprint'.

23 Jun 2020

Study reveals mechanism by which propionic acid induces brain disorders

Korea Brain Research Institute (KBRI, headed by Suh Pann-ghill) announced on the 11th that the research team led by Dr. Mun Ji-young revealed the mechanism of autism induced by an imbalance of human gut microorganisms.

19 Jun 2020

Camelina sativa oil and fatty fish have major positive effect on lipid metabolism

Camelina sativa oil and fatty fish are rich in polyunsaturated omega-3 fatty acids, but their health benefits seem to differ.

17 Jun 2020