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Researchers develop new approach to selectively turn on gene therapies in target cells

Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences in cells, and that detection then triggers production of a specific protein from a transgene, or artificial gene.

From Massachusetts Institute of Technology (MIT) 29 Oct 2021

New eToeholds could make RNA therapeutics more safer and effective

RNAs are best known as the molecules that translate information encoded in genes into proteins with their myriad of activities.

29 Oct 2021

Study reveals how glycogen is linked to thermogenesis in fat cells

Humans carry around with them, often abundantly so, at least two kinds of fat tissue: white and brown. White fat cells are essentially inert containers for energy stored in the form of a single large, oily droplet.

28 Oct 2021

Study offers novel therapeutic opportunities to prevent breast tumor recurrence

Researchers examined tumor cells that were resistant to the original treatment and identified molecular targets for therapies that could evade breast cancer recurrence.

28 Oct 2021

Correction of immune system's faulty timing may offer a new strategy to prevent severe COVID-19

Once an infection is under control, the body normally uses a biochemical messenger known as TGFβ to downgrade its immune response.

27 Oct 2021

Study uses artificial evolution to search DNA molecules for light producing deoxyribozymes

Once thought to function primarily as a storage molecule for genetic information, it is now known that DNA can also catalyze chemical reactions. Although such DNA enzymes (deoxyribozymes) have not been identified in nature, they can be isolated in the lab using powerful methods of artificial evolution.

22 Oct 2021

Scientists use DNA to create what may be the world's tiniest ruler for measuring proteins

As scientists have probed the mysteries of life down to smaller and smaller scales, they have invented tools to help them understand what they observe.

22 Oct 2021

Incorporating RNA-inspired breaking points to reduce plastic pollution

Once plastic products are used and discarded, they can linger in oceans, collecting in large "garbage patches" and harming sea life. One potential solution, a biodegradable polymer called polylactide (PLA), has so far not fully lived up to its promise, showing little sign of breakdown once in seawater.

21 Oct 2021

New biomarker can help characterize specific types of asthma and COPD

Rutgers researchers have discovered that people with asthma and chronic obstructive pulmonary disease have a protein in their lungs that leaks a small molecule into their bloodstream that restricts their breathing instead of relaxing their airways.

From Rutgers University 21 Oct 2021

Novel technique shows molecule conformations in live cells

Comprehending how proteins twist, bend, and shape-shift, as they work in cells, is vital to gain insights into diseases and normal biology.

21 Oct 2021

Experts discover effective means to design and build DNA nanostructures

Researchers recently identified the means to get the best DNA to communicate with membranes in the body.

From The University of New South Wales (UNSW) 19 Oct 2021

Novel computationally modeled proteins help control cellular processes

Doctoral assistant Sailan Shui loves to experiment with proteins, activating and deactivating them similar to turning on and off the light switches.

19 Oct 2021

Novel method enables quick identification of small active substance molecules

Secondary natural substances that occur in numerous plants, bacteria and fungi can be anti-inflammatory, can ward off pathogens or even prevent the growth of cancer cells. However, making use of the riches provided by nature's medicine cabinet and identifying new natural substances is time-consuming, costly and labour-intensive. A team of bioinformaticians at Friedrich Schiller University Jena has now developed a method that enables much faster and easier identification of small active substance molecules.

18 Oct 2021

Brain immune cells take up large amounts of sugar at the beginning of neurodegenerative disease

At the beginning of neurodegenerative disease, the immune cells of the brain – the "microglia" – take up glucose, a sugar molecule, to a much greater extent than hitherto assumed.

18 Oct 2021

Skin regeneration after an injury may be linked with motility of skin stem cells

Although sometimes hard to accept, with aging, many things in our bodies change. One of these is the ability of the skin to regenerate. Old skin is just not as good as young skin at healing wounds. However, the molecular and cellular mechanisms underlying this are largely unknown.

18 Oct 2021

Researchers refine cryogenic electron microscopy technique

$Mesenchymal stem cells with enhanced fracture healing abilities identified$

Mesenchymal stem cells with enhanced fracture healing abilities identified

Mesenchymal stem cells (MSCs) are anticipated to harbor great potential in the area of regenerative medicine, which aims at restoring damaged tissues.

8 Oct 2021

Molecule News and Research

Researchers develop new approach to selectively turn on gene therapies in target cells

New eToeholds could make RNA therapeutics more safer and effective

Study reveals how glycogen is linked to thermogenesis in fat cells

Study offers novel therapeutic opportunities to prevent breast tumor recurrence

Correction of immune system's faulty timing may offer a new strategy to prevent severe COVID-19

Study uses artificial evolution to search DNA molecules for light producing deoxyribozymes

Scientists use DNA to create what may be the world's tiniest ruler for measuring proteins

Incorporating RNA-inspired breaking points to reduce plastic pollution

New biomarker can help characterize specific types of asthma and COPD

Novel technique shows molecule conformations in live cells

Experts discover effective means to design and build DNA nanostructures

Novel computationally modeled proteins help control cellular processes

Novel method enables quick identification of small active substance molecules

Brain immune cells take up large amounts of sugar at the beginning of neurodegenerative disease

Skin regeneration after an injury may be linked with motility of skin stem cells

Researchers refine cryogenic electron microscopy technique

Infection with measles virus activates two different immune responses

Researchers develop a novel sensor to detect chemical changes in immune cells

Dimethyl sulfide emitted from the sea can never help in the formation of new clouds, study reveals

Mesenchymal stem cells with enhanced fracture healing abilities identified

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