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Novel targeted therapy blocks critical metabolic pathways in cancer cells

Scientists have designed a new targeted therapy, known as POMHEX, which inhibits vital metabolic pathways in tumor cells containing specific genetic defects.

24 Nov 2020

Study shows how drug-like small molecules regulate the activity of ion channels

Researchers have recently discovered how the function of therapeutically relevant ion channels is regulated by drug-like small molecules.

24 Nov 2020

Researchers look for mechanisms that stabilize or destabilize key sections of biomolecules

Knowing precisely where proteins are frustrated could go a long way toward making better drugs. That's one result of a new study by Rice University scientists looking for the mechanisms that stabilize or destabilize key sections of biomolecules.

24 Nov 2020

Study reveals genomic structures that allow SARS-CoV-2 virus to control the infection process

An international research alliance has visualized the RNA folding structures of the SARS-CoV-2 genome, for the first time.

23 Nov 2020

First functional analysis of cytokine IL-15L using rainbow trout

The cytokine family including interleukin-2 and -15 (IL-2 and IL-15) started out in a primitive vertebrate species with three related cytokines IL-2, IL-15, and IL-15-like (IL-15L), all sharing binding capacity for receptor chain IL-15Rα. IL-15L was conserved in fishes, reptiles, and some mammals but lost in humans and mice.

23 Nov 2020

Researchers prepare biocompatible protocells to pump up blood vessels

An international team comprising researchers from the University of Bristol, and Hunan and Central South Universities in China, have prepared biocompatible protocells.

23 Nov 2020

Vibrational motions of spike proteins correlate with infectivity, lethality of SARS-CoV-2 virus

When someone struggles to open a lock with a key that doesn't quite seem to work, sometimes jiggling the key a bit will help. Now, new research from MIT suggests that coronaviruses, including the one that causes Covid-19, may use a similar method to trick cells into letting the viruses inside.

20 Nov 2020

Scientists elucidate the structure of ABC transporter protein

A high concentration of salt or sugar in the environment will dehydrate microorganisms and stop them from growing.

19 Nov 2020

Study shows how brain protein helps pancreatic cancer cells to survive

Researchers have discovered that a protein thought to only be involved in the development of neurons in the brain also plays a major role in the development and growth of pancreatic cancer.

19 Nov 2020

Tau protein in Alzheimer's disease looks different at every dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain.

19 Nov 2020

Gold nanoparticles put spotlight on small drug molecules in live cells

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

19 Nov 2020

Study finds that cannabidiol induces the expression of heme oxygenase 1 in skin cells

At present, cannabidiol has found considerable use not just in the world of cosmetics but also in nutrition and pharmaceutics due to its therapeutic potential.

17 Nov 2020

Several hepatitis C drugs can inhibit the SARS-CoV-2 main protease

Scientists have determined that drugs meant for treating hepatitis C can block SARS-CoV-2 main protease, which allows reproduction in the novel coronavirus.

17 Nov 2020

Discovery of 'Achilles heel' in protein crucial to HIV virulence paves way for new drugs

The discovery of a potential "Achilles heel" in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus.

17 Nov 2020

New research uncovers vital link in complex biochemical pathway for saponin synthesis

Many plants, including legumes, make naturally occurring chemicals called saponins. For example, the medicinal plant licorice produces the saponin glycyrrhizin, a potent natural sweetener that also has antiviral and other pharmacological activity. Soyasaponins, found in soybeans, have anticarcinogenic and antioxidant properties.

17 Nov 2020

New way to predict who will respond to cancer therapies that block Wnt production

Scientists have identified possible means to prognosticate who will respond to cancer therapies that inhibit Wnt production.

16 Nov 2020

Astrocytes regulate inhibitory synapses by binding to neurons

In the orchestra of the brain, the firing of each neuron is controlled by two notes--excitatory and inhibitory-- that come from two distinct forms of a cellular structure called synapses.

16 Nov 2020

Researchers develop new method to produce artificial organelles in living yeast cells

Cells of higher organisms use cell organelles to separate metabolic processes from each other. This is how cell respiration takes place in the mitochondria, the cell’s power plants.

16 Nov 2020

Scientists identify new way to turn energy-poor pathway products into biorenewable ones

The imminent environmental crisis calls for an urgent transition to a green economy. A team of scientists at Nagoya University, Japan, led by Professor Susumu Saito, has recently found an interesting way to make this happen -- by leveraging an important metabolic pathway in living cells.

16 Nov 2020

Scientists identify potential targets against coronavirus

Scientists comprehensively studied the RNA genomic structure of the SARS-CoV-2 coronavirus.

11 Nov 2020

Molecule News and Research

Novel targeted therapy blocks critical metabolic pathways in cancer cells

Study shows how drug-like small molecules regulate the activity of ion channels

Researchers look for mechanisms that stabilize or destabilize key sections of biomolecules

Study reveals genomic structures that allow SARS-CoV-2 virus to control the infection process

First functional analysis of cytokine IL-15L using rainbow trout

Researchers prepare biocompatible protocells to pump up blood vessels

Vibrational motions of spike proteins correlate with infectivity, lethality of SARS-CoV-2 virus

Scientists elucidate the structure of ABC transporter protein

Study shows how brain protein helps pancreatic cancer cells to survive

Tau protein in Alzheimer's disease looks different at every dementia stage

Gold nanoparticles put spotlight on small drug molecules in live cells

Study finds that cannabidiol induces the expression of heme oxygenase 1 in skin cells

Several hepatitis C drugs can inhibit the SARS-CoV-2 main protease

Discovery of 'Achilles heel' in protein crucial to HIV virulence paves way for new drugs

New research uncovers vital link in complex biochemical pathway for saponin synthesis

New way to predict who will respond to cancer therapies that block Wnt production

Astrocytes regulate inhibitory synapses by binding to neurons

Researchers develop new method to produce artificial organelles in living yeast cells

Scientists identify new way to turn energy-poor pathway products into biorenewable ones

Scientists identify potential targets against coronavirus

Gaining new insights into bacterial pneumonia

Discovering a new step in immune cell generation

Developing a new method to reduce antibiotic resistance in waterways

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