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Scientists Identify Drug-Binding Site on FOXA1

Forkhead box protein 1 (FOXA1) is a difficult-to-target protein that is frequently involved in hormone-driven malignancies, such as those of the breast and prostate.

16 Oct 2024

Advanced Model Predicts Nucleosome Positions with High Precision

DNA-;the molecule that carries the genetic information of all living organisms-;is packaged within cells in a complex manner that allows it to function efficiently.

15 Oct 2024

New Insights into How Plants Regulate Growth and Development

Plants form new leaves, flowers and roots at the tips of shoots and roots, in specific growth regions known as meristems. These meristems contain stem cells that divide as needed and form new cells that develop into specialized tissue.

15 Oct 2024

Unveiling a New Cellular Phase for Protein Compartmentalization

Classical mixture theory, which takes into account the percentage corresponding to each constituent as well as the interactions among constituents, can be used to model a system made up of two substances in physics.

14 Oct 2024

Researchers Discover Key Genes for Plant Stress Tolerance

New research identifies for the first time the genes that help plants grow under stressful conditions - with implications for producing more sustainable food crops in the face of global climate change.

10 Oct 2024

Unveiling the Link Between Genetics, Stress, and Type 2 Diabetes

The cells in the human pancreas have a limit to how much stress they can withstand before degenerating.

10 Oct 2024

New Method for Identifying Kinase Inhibitors for Cancer Therapy

The most difficult subtype of breast cancer to treat is triple-negative breast cancer (TNBC). Over 20,000 cases of TNBC are reported each year in the United States alone.

10 Oct 2024

Researchers Develop Highly Selective SARS-CoV-2 Mpro Inhibitors

New research from The Wistar Institute's Salvino lab -; led by professor Joseph Salvino, Ph.D. -; has identified a novel series of SARS-CoV-2 Mpro inhibitors that may lead to potential new COVID-19 treatments that, according to preclinical testing, effectively inhibits COVID-19 and synergizes with existing anti-COVID therapies.

9 Oct 2024

New RNA Molecule Found to Boost Wound Healing

A new study from Karolinska Institutet in Sweden and the Chinese Academy of Medical Sciences has identified an RNA molecule that is important for skin wound healing. The research, published in Nature Communications, may have implications for the treatment of hard-to-heal wounds.

9 Oct 2024

Engineering Tissue Domains with a Synthetic Biology Approach

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, demonstrate how morphogens combined with cell adhesion can generate tissue domains with a sharp boundary in an in vitro model system.

9 Oct 2024

Study Unravels the Mystery of Hsp70 Chaperones

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control protein quality.

9 Oct 2024

Fighting Drug-Resistant TB with a Novel Antibiotic

A novel semi-synthetic molecule that produces significant activity against strains of Mycobacterium tuberculosis, including those that are resistant to drugs, can be generated from natural compounds according to a study published in the American Society for Microbiology journal Microbiology Spectrum.

4 Oct 2024

Harnessing Bioluminescence for Noninvasive Brain Activation

Researchers at the University of Rochester have demonstrated a noninvasive technique called bioluminescent optogenetics, or BL-OG, that uses light to stimulate brain neurons.

4 Oct 2024

Mapping the Complex Structure and Function of CRISPR-Cas Protein Scissors

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions.

3 Oct 2024

Discovering New Drug Targets Through Paralog Hopping

Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites.

3 Oct 2024

Mosquitoes use Salivary Protein to Aid Malaria Parasite Transmission

The study identifies AgApyrase as a key protein in mosquito saliva, enhancing Plasmodium transmission by regulating blood clot breakdown and immune response.

30 Sep 2024

Insights into the Formation of Nascent Membrane Structures in Yeast Sporulation

Sexual reproduction, a common mode of reproduction among numerous species, involves gametogenesis in which offspring are produced through fertilization, conjugation, or mating. In plants and animals, eggs and sperm differentiate from germ cells to form gametes.

30 Sep 2024

Neutron Scattering Reveals Enzyme Secrets

Scientists have uncovered amazing information about the role of an enzyme that could assist in the development of drugs for aggressive cancers in just two neutron experiments.

25 Sep 2024

Study Uncovers Cholesterol's Role in Membrane Structure and Function

A new study by Rice University researchers led by Jason Hafner could open new pathways for understanding how cholesterol influences cell membranes and their receptors, paving the way for future research on diseases linked to membrane organization.

24 Sep 2024

A New Method to Correct Misplaced Proteins in Cells

Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In some cancers, for instance, a protein that normally stands watch over DNA replicating in the nucleus is sent far from the DNA it is meant to monitor, allowing cancers to grow.

23 Sep 2024