Neurodegenerative Disease News and Research

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Unveiling Mechanisms to Block Tau Aggregation

The buildup of aberrant, misfolded tau proteins in the brain is the cause of a variety of neurodegenerative illnesses, such as Fronto Temporal Dementia (FTD), Progressive Supranuclear Palsy (PSP), and Cortico Basal Degeneration (CBD).

4 Apr 2024

Unraveling the Mysteries of Neuronal Communication Circuits

The basic building blocks of the central nervous system are neurons, or nerve cells, which play a crucial role in signal transduction pathways.

3 Apr 2024

Study Investigates Links Between Gene Expression and Primate Brain Evolution

An interdisciplinary team of researchers led by biologists at the University of Massachusetts Amherst recently published the results of a first-of-its-kind study investigating the links between gene expression and brain evolution across 18 primate species.

1 Apr 2024

New Theory Links Gene Length to Cellular Decline

A gene’s length may have more to do with aging than particular “aging genes.” Reduced expression of long genes may be the cause of many aging-related changes, according to researchers writing an opinion piece that was published in the journal Trends in Genetics on March 21st, 2023.

25 Mar 2024

Unraveling the Role of Gene Length in Aging

Aging may be less about specific "aging genes" and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece publishing March 21 in the journal Trends in Genetics.

22 Mar 2024

Astrocyte-Rich Brain Organoid Model Unveils Insights into Neuroinflammation

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.

1 Mar 2024

Uncovering How to Protect Nerves in Neurodegenerative Diseases

Researchers at the Case Western Reserve University School of Medicine have led a team that has discovered a novel therapeutic strategy for treating neurodegenerative illnesses, raising the prospect of better care for conditions like multiple sclerosis, Alzheimer's disease, Parkinson's disease, and Vanishing White Matter disease.

21 Feb 2024

APOE4's Influence on Lipid Droplets in Brain Cells

The largest genetic risk factor for late-onset Alzheimer's disease is apolipoprotein E (APOE), and researchers Sarah Cohen, PhD, and Ian Windham, a former PhD student from the Cohen group, have made a novel discovery about this protein.

12 Feb 2024

Ancient DNA Reveals Reason for High Multiple Sclerosis and Alzheimer’s Rates in Europe

Researchers have created the world’s largest ancient human gene bank by analysing the bones and teeth of almost 5,000 humans who lived across western Europe and Asia up to 34,000 years ago.

10 Jan 2024

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

26 Dec 2023

Misfolded Proteins: How They Damage Neurons and Cause Neurodegeneration

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death.

5 Dec 2023

New Drug-Like Molecule Enhances Mitophagy, Protects Against Neurodegeneration

Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process.

14 Nov 2023

Study Identifies Significant Changes in Peptides During Pyroglutamination

Peptides are biomolecules formed when two or more amino acids that perform key functions in the human organism, such as hormones, neurotransmitters, painkillers and antibiotics, bind together. For this reason, they are much studied and used by the pharmaceutical industry, for example.

2 Nov 2023

Study Links Autism Gene to Broad Spectrum of Molecular and Cellular Defects

Researchers have used CRISPR gene editing, stem cells and human neurons to study the impact of a gene that is commonly mutated in autism.

6 Oct 2023

Slowing down Alzheimer’s with Specialized T Cells

Alzheimer’s disease, a neurological disorder characterized by gradual cognitive decline, including memory loss, affects up to 5.8 million Americans today. Protein aggregates made up of beta-amyloid or other proteins occur in the brains of Alzheimer’s patients. These beta-amyloid plaques appear to be a major cause of the disease.

8 Sep 2023