OCT News and Research

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Novel method enables quick identification of small active substance molecules

Secondary natural substances that occur in numerous plants, bacteria and fungi can be anti-inflammatory, can ward off pathogens or even prevent the growth of cancer cells. However, making use of the riches provided by nature's medicine cabinet and identifying new natural substances is time-consuming, costly and labour-intensive. A team of bioinformaticians at Friedrich Schiller University Jena has now developed a method that enables much faster and easier identification of small active substance molecules.

18 Oct 2021

AI-powered tool rapidly identifies genetic causes of rare disorders with high accuracy

An artificial intelligence (AI)-based technology rapidly diagnoses rare disorders in critically ill children with high accuracy, according to a report by scientists from University of Utah Health and Fabric Genomics, collaborators on a study led by Rady Children's Hospital in San Diego. The benchmark finding, published in Genomic Medicine, foreshadows the next phase of medicine, where technology helps clinicians quickly determine the root cause of disease so they can give patients the right treatment sooner.

From The University of Utah 18 Oct 2021

Researchers develop chimeric exosomes that co-activate immune response and tumor microenvironment

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed macrophage–tumor chimeric exosomes that co-activate the immune response and tumor microenvironment to support cancer immunotherapy.

18 Oct 2021

Brain immune cells take up large amounts of sugar at the beginning of neurodegenerative disease

At the beginning of neurodegenerative disease, the immune cells of the brain – the "microglia" – take up glucose, a sugar molecule, to a much greater extent than hitherto assumed.

18 Oct 2021

Pioneering gene therapy has long-lasting effects on children with deadly immune disorder

Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free.

18 Oct 2021

Researchers uncover how killer T cells repeatedly reload their toxic weapons to keep on killing

Cambridge researchers have discovered how T cells – an important component of our immune system – are able keep on killing as they hunt down and kill cancer cells, repeatedly reloading their toxic weapons.

15 Oct 2021

Infection with measles virus activates two different immune responses

Researchers from The University of Tokyo Institute of Industrial Science have found that infection with the measles virus activates not one but two different branches of the innate immune system.

15 Oct 2021

Mutant clones outcompete and eliminate early tumors, mouse study shows

Cells carrying mutations can out compete early tumors in the mouse esophagus, so they never make it into cancers, new research has shown.

15 Oct 2021

Type A immunoglobulins play a key role in keeping the intestinal flora in balance

The bacteria living in the intestine consist of some 500 to 1000 different species. They make up what is known as the intestinal flora, which plays a key role in digestion and prevents infections.

15 Oct 2021

Scientists show how skin T cells can damage other organs in stem cell transplant patients

More than 40,000 allogeneic hematopoietic stem cell transplants are carried out worldwide every year, mostly for patients suffering from leukemia or other diseases of the hematopoietic system.

15 Oct 2021

Study identifies DNA mutations that impact metabolism and insulin sensitivity in liver disease patients

For the first time, DNA mutations in liver cells have been identified that impact metabolism and insulin sensitivity in patients with liver disease.

15 Oct 2021

Molecular atlas of small cell lung cancer reveals signatures of metastasis and immunosuppression

Imagine you're about to go on a cross-country trip, stopping at spots along the way to admire local attractions.

15 Oct 2021

Researchers discover how neurons filter distracting signals to coordinate movements

As you read this article, touch receptors in your skin are sensing your environment. Your clothes and jewelry, the chair you're sitting on, the computer keyboard or mobile device you're using, even your fingers as they brush one another unintentionally-;each touch activates collections of nerve cells.

15 Oct 2021

Study reveals gene responsible for food-dependent form of Cushing's Syndrome

A team of scientists in Montreal and Paris has succeeded in identifying the gene responsible for the development of a food-dependent form of Cushing's Syndrome, a rare disease affecting both adrenal glands.

15 Oct 2021

Parents' stress during COVID-19 affected eating habits of children

The incredible stress parents experienced during the COVID-19 pandemic had a negative effect on the eating habits of their children, according to a new study by researchers at the University of Houston College of Education.

13 Oct 2021

Dimethyl sulfide emitted from the sea can never help in the formation of new clouds, study reveals

Stand on the ocean's shore and take a big whiff of the salt spray and you'll smell the unmistakably pungent scent of the sea. That ripe, almost rotting smell? That's sulfur.

12 Oct 2021

Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk

A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer's disease treatment for those who are at genetic risk, according to findings published in Nature Aging.

12 Oct 2021

Newly developed method helps refine the "Out of Africa" scenario

Researchers from Estonia and Italy developed an innovative method by combining neural networks and statistics. Using this newly developed method, they refined the "Out of Africa" scenario. The researchers claimed that the African dynamics around the time of the Out of Africa expansion are more complex than previously thought.

11 Oct 2021

Researchers reconstitute the biological clock to better understand circadian rhythms

Daily cycles in virtually every aspect of our physiology are driven by biological clocks (also called circadian clocks) in our cells.

From University of California Santa Cruz 8 Oct 2021

Wild meat consumption reduces greenhouse gas emissions, study reveals

Consuming sustainably sourced wild meat instead of domesticated livestock reduces greenhouse gas emissions and retains precious tropical forest systems, which in turn mitigates the effects of climate change.

8 Oct 2021

OCT News and Research

Novel method enables quick identification of small active substance molecules

AI-powered tool rapidly identifies genetic causes of rare disorders with high accuracy

Researchers develop chimeric exosomes that co-activate immune response and tumor microenvironment

Brain immune cells take up large amounts of sugar at the beginning of neurodegenerative disease

Pioneering gene therapy has long-lasting effects on children with deadly immune disorder

Researchers uncover how killer T cells repeatedly reload their toxic weapons to keep on killing

Infection with measles virus activates two different immune responses

Mutant clones outcompete and eliminate early tumors, mouse study shows

Type A immunoglobulins play a key role in keeping the intestinal flora in balance

Scientists show how skin T cells can damage other organs in stem cell transplant patients

Study identifies DNA mutations that impact metabolism and insulin sensitivity in liver disease patients

Molecular atlas of small cell lung cancer reveals signatures of metastasis and immunosuppression

Researchers discover how neurons filter distracting signals to coordinate movements

Study reveals gene responsible for food-dependent form of Cushing's Syndrome

Parents' stress during COVID-19 affected eating habits of children

Dimethyl sulfide emitted from the sea can never help in the formation of new clouds, study reveals

Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk

Newly developed method helps refine the "Out of Africa" scenario

Researchers reconstitute the biological clock to better understand circadian rhythms

Wild meat consumption reduces greenhouse gas emissions, study reveals

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