Osteoarthritis News and Research

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According to the Arthritis Foundation, 66 million (nearly one in three adults) suffer from chronic joint pain and 21 million Americans suffer from osteoarthritis (OA), the most common form of arthritis, which is characterized by a breakdown of the cartilage and a deterioration of the fluid in a joint. The symptoms of osteoarthritis include pain, from moderate to severe, and stiffness. Most people who have osteoarthritis are older than age 45, and women are more commonly affected than men.

Histone Variant H2AZ1 Identified as Key Driver of Stem Cell Aging

Cellular senescence-a state of irreversible growth arrest accompanied by chronic inflammation-is a major contributor to aging and tissue degeneration.

18 Jun 2025

Spatial Transcriptomics Reshapes Musculoskeletal Research and Therapy

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context.

10 Jun 2025

New Genetic Discoveries Offer Hope for Osteoarthritis Treatments

Researchers have uncovered multiple new genes and genetic pathways that could lead to repurposing hundreds of existing drugs for osteoarthritis, the most common form of arthritis.

29 Apr 2025

Allegro’s Injectable Osteoarthritis Treatment Generates Positive Safety Results in Preclinical Studies

Allegro NV, a biomedical company developing transformative nanotechnology-based treatments for degenerative joint disease, has found that hydrocelin (ALG-001), its injectable microparticle hydrogel, showed no signs of toxicity in two preclinical studies conducted for periods of 4 and 13 weeks respectively.

25 Mar 2025

Viking Skulls Show Evidence of Disease and Painful Conditions

Sweden's Viking Age population appears to have suffered from severe oral and maxillofacial disease, sinus and ear infections, osteoarthritis, and much more.

24 Feb 2025

Extracellular Vesicles from Mesenchymal Stromal Cells Restore Joint Health in Osteoarthritis

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 22, 2024, entitled, "Anti-aging effect of extracellular vesicles from mesenchymal stromal cells on senescence-induced chondrocytes in osteoarthritis."

20 Dec 2024

New Approach Aims to Enhance CRISPR Safety and Precision

CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism.

8 Oct 2024

Research Shows Evolutionary Divergence in Knee Bones of Primates

The evolution of bones in primates' knees could have implications for how humans evolved to walk upright, a new study has found.

11 Sep 2024

SGLT-2 Inhibitors May Lower Dementia Risk in Type 2 Diabetes Patients, Study Finds

A study reveals SGLT-2 inhibitors significantly reduce dementia risk in type 2 diabetes patients, with effects strengthening over longer treatment durations.

9 Sep 2024

From Bone Regeneration to Heart Repair: Stem Cell Transplantation Paves the Way for New Medical Frontiers

Stem cell transplantation offers promising solutions for tissue regeneration and age-related degeneration, despite challenges in safety and production costs.

9 Sep 2024

Injectable Therapy Using 'Dancing Molecules' Promises New Hope for Cartilage Repair

In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving "dancing molecules," to repair tissues and reverse paralysis after severe spinal cord injuries.

29 Jul 2024

Non-Destructive Test Identifies Potent Cartilage Repair Cells

Researchers from Critical Analytics for Manufacturing Personalized-medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, and collaborators from the National University of Singapore Tissue Engineering Programme (NUSTEP) have discovered a more efficient method for evaluating the ability of mesenchymal stromal cells (MSCs) to regenerate cartilage.

3 Jun 2024

Sirtuin 6 Boosts DNA Repair in Aging Cartilage Cells

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes."

20 Dec 2023

SMART Researchers Pioneer Novel Microfluidic Method to Optimize Bone Marrow Stem Cell Extraction for Advanced Cell Therapies

Researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with the Agency for Science, Technology and Research (A*STAR) Bioprocessing Technology Institute (BTI) and National University Health System (NUHS), have developed a groundbreaking technology.

22 Nov 2023

Researchers Identify Key Cells Involved in the Process of Cartilage Regeneration in Lizards

A team of researchers from the Keck School of Medicine of USC have published the first detailed description of the interplay between two cell types that allow lizards to regenerate their tails.

11 Aug 2023

Researchers Pinpoint the Genes that Shape the Skeletons

Using artificial intelligence to analyze tens of thousands of X-ray images and genetic sequences, researchers from The University of Texas at Austin and New York Genome Center have been able to pinpoint the genes that shape our skeletons, from the width of our shoulders to the length of our legs.

21 Jul 2023

Study identifies previously unknown cell types that drive the onset of osteoarthritis

A Michigan Medicine study has identified a new potential target for treating osteoarthritis – a debilitating joint disease that affects over 31 million Americans and is a leading cause of disability worldwide.

10 Mar 2023

Preclinical study describes a promising approach to regenerate damaged cartilage

Osteoarthritis – a painful condition that results from the deterioration of the cartilage in our joints – affects millions of people worldwide.

6 Jun 2022

Researchers regenerate cartilage using novel protein fragment

The existing methods for the regeneration of injured cartilage generate tissue that breaks down. This deterioration eventually leads to osteoarthritis—the commonly seen form of arthritis—affecting over 32.5 million grown-ups in the United States, as per the Centers for Disease Control and Prevention.

13 Dec 2021

Study identifies genes involved in people with osteoarthritis

The major cause of pain and disability globally is osteoarthritis.

1 Nov 2021