RNA Sequencing News and Research

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New toolkit enables researchers to map an individual’s RNA data to a much richer reference

Examining the gene expression of a person needs mapping the RNA landscape to a standard reference. This is done to gain an understanding of the degree to which genes are “turned on” and execute the functions in the body.

From University of California Santa Cruz 18 Jan 2023

Insights into the role of the germline in de novo mutation

The male reproductive system is a hotspot for the introduction of new genes. Perhaps that might assist in understanding why fathers tend to pass on more new mutations than mothers do. However, it does not explain why older fathers pass on more mutations than younger fathers.

16 Jan 2023

Researchers gain insights into how density may change gene expression in some insects

A grasshopper hatched in a crowded environment may look and behave differently than a grasshopper hatched in isolation -; even if they have the same genes.

14 Dec 2022

Novel method for comparing single-cell trajectories with tree alignment

The genes that are activated in a single cell can now be determined thanks to advances in high-throughput biological studies. However, interpreting the resulting complex datasets might be difficult.

From Osaka University 20 Oct 2022

An accurate overview of gene activity could provide targeted therapies

Normal gene activity in the afflicted cells is changed during pathological events. Therefore, obtaining a precise picture of gene activity could hold the key to the creation of new, targeted therapies.

18 Oct 2022

New guidelines to generate high-quality, well-structured organoids

Researchers have opened a new avenue for investigations of neurological development, disease, and therapies that cannot be undertaken in living people by employing stem cells to grow small brain-like structures in the lab.

30 Sep 2022

New insights into the regulatory mechanisms of cell fate decisions

The Babraham Institute’s Reik lab’s study has improved the understanding of the function of DNA methylation during the early stages of development.

29 Sep 2022

Interactions between plasma miRNAs and cognitive performance in males

Cognitive decline brought on by aging is a precursor to dementias like Alzheimer’s and can have a significant impact on a person’s ability to carry out essential daily tasks.

16 Sep 2022

Unique combination of transcription factors trigger cell regeneration in zebrafish

Scientists at the National Institutes of Health have identified a particular protein network required for cell regeneration to restore hearing in zebrafish.

From National Human Genome Research Institute (NHGRI) 15 Sep 2022

New type of chip could lead to earlier and more targeted treatment for cancer

Cancer spreads via circulating tumor cells (CTCs) that travel through the blood to other organs, and they are nearly impossible to track.

17 Aug 2022

Scientists expand entomological research using genome editing

Genome sequencing, in which researchers use laboratory approaches to predict the genetic makeup of a particular organism, is becoming more common in insect studies.

26 Jul 2022

Study shows how new single-cell RNA-sequencing helps to analyze gene expression

One of the most crucial techniques for examining biological activity in cells is single-cell RNA sequencing, but it is constrained by the possibility that the data it produces may be inaccurate.

From Tokyo University of Science 1 Jul 2022

INTEGRA solutions helping to support a new generation of RNA sequencing

INTEGRA Biosciences’ electronic handheld pipetting solutions are helping to improve the throughput capacity of bulk RNA barcoding and sequencing (BRB-seq) at Alithea Genomics in Switzerland.

From INTEGRA Biosciences 17 Jun 2022

Differentiation protocol can develop safe and efficient pluripotent stem cell-based therapies for AMD

As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems.

16 Jun 2022

Researchers create open-access atlases of human immune cells in adults

Previously unknown immune cell types throughout development and adulthood have been identified, providing new insights into how the human immune system functions.

18 May 2022

New software device makes genetic information analysis simpler

Researchers from Texas Biomedical Research Institute and Tulane University have created a new software device that makes analyzing genetic data about a host and its microbiome at the very same time simpler, quicker, and less expensive.

10 May 2022

Researchers analyze immune system genetic diversity, likely to affect endangered toad existence

The immune system diversity of the critically endangered Wyoming toad is examined in new research, which indicates that genetic bottlenecks can affect a species’ capabilities to react to novel infections.

3 May 2022

Gene expression signatures in lymph node cells play an active role in lymphoma development

Researchers from the University of Tsukuba identify gene expression signatures in different types of lymph nodes cells that play an active role in the development of lymphomas.

3 May 2022

Bone growth protein may help treat newborns with rare genetic lung condition

When babies are born with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), their skin starts to turn blue from the under-oxygenated blood in their systems.

22 Apr 2022

New research shows significant variations in B-cells in women with PPD

Jerry Guintivano, PhD, of the University of North Carolina School of Medicine, led an exclusive transcriptome-wide association research that showed substantial changes in B-cells in women with postpartum depression, with pathway observations indicating modified B-cell activation and insulin resistance.

19 Apr 2022