Ribosome News and Research

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New Insight into the Dynamics of a Ribosomal Protein - RPL3L

A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.

23 May 2023

Long-Ignored Antibiotic may Provide Much-Needed Protection Against Multi-Drug Resistant Bacteria

An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues.

17 May 2023

Revealing an Unanticipated Mechanism for Chaperone-Mediated Ribosome Repair

Researchers have discovered that if oxidative stress destroys protein factories known as ribosomes, repair crews may go in to assist in repairing the damage so that production may restart rapidly.

26 Apr 2023

Two Molecular Mechanisms Combine to Make the Bacterium Extra Resistant

When the intestinal flora is killed by antibiotics, a species of ordinary gut bacteria that humans carry flourishes. Because the bacteria are naturally immune to many drugs, it poses complications, especially in healthcare settings.

18 Apr 2023

The protein synthesis mechanism in the Giardia parasite

Cryo-electron microscopy was employed by Uppsala University researchers to reveal information on the protein synthesis mechanism in the parasite Giardia intestinalis, which causes diarrhea. The new findings could help in the development of specific medicines to combat Giardia and other protozoan parasites.

20 Mar 2023

Using a programmable control switch to deliver therapeutic RNA molecules to target cells

Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene.

17 Mar 2023

Nanosatellite paves the way for developing RNA-based medicines

Researchers from Aarhus University and Berkeley Laboratory have designed RNA molecules, that folds into nanoscale rectangles, cylinders, and satellites, and have studied their 3D structure and dynamics with advanced nanotechnological methods.

28 Feb 2023

Learning about cellular proteins through “snapshots” of translation

Pep-tRNAs, nascent polypeptides inside the ribosome that are covalently connected to transfer RNA, are engaged in a variety of cell processes, including gene expression, according to advances in molecular biology.

1 Feb 2023

Novel insights into the elongation dynamics of eukaryotic cells

The proper functioning of numerous proteins generated in cells by ribosomes is essential for life. This diversified variety of proteins, called proteome, is sustained by the ribosomes’ vigorous translation elongation of amino acid sequences.

6 Jan 2023

An accurate overview of gene activity could provide targeted therapies

Normal gene activity in the afflicted cells is changed during pathological events. Therefore, obtaining a precise picture of gene activity could hold the key to the creation of new, targeted therapies.

18 Oct 2022

The ability of cells to adjust their growth to changing environmental conditions

Growth is a fundamental element of all life on this planet, whether it be a mammal, a single-celled organism, a plankton, or a sequoia.

18 Oct 2022

Therapeutic mRNAs do not significantly impact translational fidelity

Synthetic mRNA therapeutics for the treatment and prevention of disease has attracted a lot of interest due to the exceptional efficacy of mRNA vaccinations against SARS-CoV-2.

30 Aug 2022

Researchers explore how tRNAs evolve in protein synthesis

In the process of protein synthesis, a peptide bond is formed between two amino acids that are bound to two different transfer RNAs (tRNAs). Researchers have long been perplexed as to how these tRNAs evolved to be so near to one another on the ribosome.

From Tokyo University of Science 22 Apr 2022

Researchers determine major protein complexes that cause ribosome production

Scientists at UT Southwestern have discovered a four-protein complex that seems to play a significant function in the formation of ribosomes, which serve as protein factories for cells, as well as a surprise role in neurodevelopmental diseases.

1 Apr 2022

Cryo-EM reveals how a bacterial protein senses and rescues stalled ribosomes

As a molecular machine found in the cells of all organisms, the ribosome is responsible for making new proteins.

11 Mar 2022

Scientists study the distant connection between Archaea and Bacteria

Researchers have discovered more evidence to support the idea that the two primary domains of life, Archaea and Bacteria, are detached by a long phylogenetic tree branch.

24 Feb 2022

Human rRNA genes differed based on a person’s geographic ancestry

Genome research that explored gene variants that are considered a crucial building block for protein-synthesizing microscopic structures took an unexpected turn.

4 Feb 2022

Stanford study reveals how ribosomes may contribute to age-related diseases

Aging leads to a decline in cellular fitness and loss of optimal protein function. Many age-related ailments, including Alzheimer's and Parkinson's diseases, are caused by protein aggregation, a result of errors in protein folding.

20 Jan 2022

Viral RNA undergoes conformational changes to hijack host cells, says study

Scientists from the University of Colorado Anschutz Medical Campus recently identified how an RNA molecule from a virus develops a complex, three-dimensional structure, and is capable of changing its shape to hijack host proteins.

25 Nov 2021

Researchers develop new approach to selectively turn on gene therapies in target cells

Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences in cells, and that detection then triggers production of a specific protein from a transgene, or artificial gene.

From Massachusetts Institute of Technology (MIT) 29 Oct 2021