Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox — the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body.
A common strategy to make vaccines more powerful is to deliver them along with an adjuvant -; a compound that stimulates the immune system to produce a stronger response.