Ubiquitin News and Research

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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

Study Reveals How Cells Recycle Proteins in Response to Nutrient Starvation

A new study details how nutrient-starved cells divert protein transport stations to cellular recycling centers to be broken down, highlighting a novel approach cells use to deal with stressful conditions.

15 Apr 2024

U of T Researchers Develop Groundbreaking Platform for Protein-Based Disease Treatment

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.

25 Mar 2024

Study unveils how our cells outsmart invaders without turning against us

The human immune system is a sophisticated network of cells and proteins created to defend against dangerous infections, and cells continuously repel invaders in a microscopic war raging inside human bodies.

29 Feb 2024

Nanopore Sequencing Sheds Light on Plant Growth Trigger

Researchers from the Southern University of Science and Technology, under the direction of Prof. Xiaofeng Cao from the Chinese Academy of Sciences’ Institute of Genetics and Developmental Biology, recently reported a new understanding of how light affects plant growth in a study that was published in the PNAS.

5 Feb 2024

NEMO Protein Promotes Degradation of Harmful Alpha-Synuclein Aggregates in Parkinson's Disease

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

21 Dec 2023

Unlocking the Mystery of N-Terminal Acetylation’s Impact on Protein Degradation

Scientists at the University of Bergen (UiB) have discovered that proteins employ a shared chemical marker as a protective shield against degradation, thereby influencing their mobility and the aging process.

30 Oct 2023

Scientists Develop Molecular Radar to Detect Active Cullin-RING Ligases

Our cells have a fleet of 300 molecular machines, called cullin-RING ligases, or "CRLs" for short, that each is capable of triggering destruction of specific proteins for the well-being of our cells.

27 Sep 2023

Scientists Uncover New Mechanism for Degrading Short-Lived Proteins

Short-lived proteins control gene expression in cells to carry out a number of vital tasks, from helping the brain form connections to helping the body mount an immune defense. These proteins are made in the nucleus and are quickly destroyed once they've done their job.

25 Aug 2023

How the Disturbed Recycling Chain of Endoplasmic Reticulum Causes Neurodegenerative Diseases

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.

29 May 2023

Protein Discovery Could Lead to Better Treatment for Females with PTSD

From humans to plants to single-cell organisms, there's a protein that rules them all.

22 May 2023

Study identifies genetic variants linked to mathematical abilities in children

A new study published in Genes, Brain and Behavior has identified several genetic variants that may be linked with mathematical abilities in children.

23 Feb 2023

New approach to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

16 Feb 2023

Identifying the molecular switch that regulates autophagy in plants

Autophagy, commonly known as “self-eating,” is a cellular quality control mechanism that relieves the cell of protein aggregates and damaged organelles. This system is inert under ordinary conditions and is only activated in the presence of persistent cellular stress.

13 Feb 2023

Deubiquitinating enzymes vital for endosomal transport identified

The University of Konstanz’s Plant Physiology and Biochemistry research group has discovered previously unrecognized molecular mechanisms by which plants acclimatize to their environment—vital basic knowledge in times of climate change.

28 Nov 2022

Delicate strategy employed by pathogens to suppress pyroptosis

Mycobacterium tuberculosis (Mtb), the bacteria that causes tuberculosis (TB), continues to be a major infectious threat to global public health.

18 Oct 2022

Researchers propose a way to identify Chlamydia, a deadly bacterial disease

Chlamydia, the most common bacterial infection associated with sexually transmitted diseases, hides inside human cells using a cloaking mechanism to avoid detection and destruction.

9 Sep 2022

SLFN11’s surveillance part in protein homeostasis

On July 25th, 2022, a new study perspective called “SLFN11’s surveillance role in protein homeostasis” was published in Volume 9 of Oncoscience.

8 Aug 2022

Scientists create new live-attenuated influenza vaccine technique over pathogens

The use of attenuated, live viruses as vaccines is a potential method to minimize the effects of viral infectious diseases, such as influenza.

8 Jul 2022

OTUD3 shows opposing effects in innate immunity to RNA and DNA viruses

The identification of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs) is the first step in initiating an immune response to viral infection.

13 Jun 2022

Study provides new knowledge on the influence of membrane proteins on plant growth

Ubiquitin is a tiny regulatory protein that can be present in most eukaryotic cells. It is important for changing the function of other proteins, and it is especially important for protein breakdown and localization inside the cell. Ubiquitin regulates these actions through ubiquitination (attaching to and detaching from a target protein).

6 Jun 2022