Ulcerative Colitis News and Research

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Ulcerative colitis is a common inflammatory disease of the colon characterized by inflammation and ulceration of the large bowel and rectum. The condition impairs the ability of the large bowel to absorb water which results in diarrhea, the main symptom of the condition.

Ulcerative colitis is a relapsing and remitting condition, meaning symptoms can die down for long periods but then flare-up from time to time. These flare-ups can be sudden and severe. During a period of relapse, symptoms may include bloody diarrhea, abdominal pain and a sudden urge to defecate. Other symptoms include wind, loss of appetite, weight loss, fever and fatigue.

Currently, there is no cure for the condition apart from surgery. However, certain treatments such as corticosteroids or immunosuppressants may be used to ease symptoms by reducing inflammation. Surgery for severe ulcerative colitis that does not respond to treatment involves completely removing the large bowel and re-routing the small bowel so that waste can still be expelled. This procedure is called a colectomy.

In the UK, the incidence of ulcerative colitis is around 1 in 500 and the condition is equally common among males and females. Symptoms can develop at any age, but onset usually occurs between 15 and 30 years of age.
Using in vivo self-assembled siRNA as part of combination therapy for ulcerative colitis

Using in vivo self-assembled siRNA as part of combination therapy for ulcerative colitis

SLFN11’s surveillance part in protein homeostasis

SLFN11’s surveillance part in protein homeostasis

Study shows how innate lymphoid cells may help to treat inflammatory bowel disease

Study shows how innate lymphoid cells may help to treat inflammatory bowel disease

Gut viruses contribute to human health, but provoke inflammation when perturbed

Gut viruses contribute to human health, but provoke inflammation when perturbed

Novel mechanistic insight into how gut bacteria work to tame intestinal inflammation

Novel mechanistic insight into how gut bacteria work to tame intestinal inflammation

Scientists develop a new computational biology method to better understand IBD

Scientists develop a new computational biology method to better understand IBD

Infusion of intestinal organoids to replace damaged intestinal tissue

Infusion of intestinal organoids to replace damaged intestinal tissue

Groundbreaking discovery could lead to the design of novel therapeutics for wound-healing

Groundbreaking discovery could lead to the design of novel therapeutics for wound-healing

People with inflammatory bowel disease have more fecal microplastics

People with inflammatory bowel disease have more fecal microplastics

300 million grant enables the establishment of new international stem cell research center

300 million grant enables the establishment of new international stem cell research center

Research demonstrates how diet affects immunity through the gut microbiome

Research demonstrates how diet affects immunity through the gut microbiome

Enteric glial cells play a major role in gut immunity, says new study

Enteric glial cells play a major role in gut immunity, says new study

New consortium of bacteria can be used to treat aggressive colitis in humanized mouse models

New consortium of bacteria can be used to treat aggressive colitis in humanized mouse models

New technology improves efficacy of inflammatory bowel disease drugs

New technology improves efficacy of inflammatory bowel disease drugs

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

New model can help identify potential drug targets for ulcerative colitis

New model can help identify potential drug targets for ulcerative colitis

Researchers demonstrate potential preventive treatment for Crohn's disease

Researchers demonstrate potential preventive treatment for Crohn's disease

Research may lead to new strategies for calcium malabsorption

Research may lead to new strategies for calcium malabsorption

Researchers find genetic correlations between inflammatory bowel disease and stress, depression

Researchers find genetic correlations between inflammatory bowel disease and stress, depression

Severe ulcerative colitis linked to newly-discovered strain of oral bacteria

Severe ulcerative colitis linked to newly-discovered strain of oral bacteria