NYU Tandon professors show broad therapeutic potential of novel peptide to combat multiple diseases

NYU Tandon professors Mary Cowman and Jin Ryoun Kim recently published a paper describing a novel peptide with broad therapeutic potential to combat chronic inflammation in multiple diseases.

The peptide, called Amilo 5-MER, was discovered by Professor David Naor and his colleague Dr. Shmuel Jaffe Cohen in the Faculty of Medicine at the Hebrew University of Jerusalem in Israel. They showed that Amilo 5-MER has anti-inflammatory effects that reduce pathological and clinical symptoms in mouse models for rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.

Based on Naor's finding that the peptide binds to several proteins associated with inflammation, including Serum Amyloid A (SAA), Cowman and Kim proposed a working mechanism for the peptide. In a collaboration between the Israeli and Tandon teams they were able to show that the peptide inhibits aggregation of SAA into more pro-inflammatory and pro-amyloidogenic forms. Amyloid-type aggregation of proteins is associated with many diseases, and the Amilo 5-MER peptide has been found to bind to other aggregating proteins that play key roles in chronic inflammations and neurodegenerative diseases. Thus, the peptide could have significant therapeutic value in many other pathological conditions, such as Alzheimer's Disease, AA amyloidosis, and even COVID-19.

The project was supported by the Ines Mandl Research Foundation (IMRR), which is dedicated to providing research funding in the fight against connective tissue disease. It is the legacy of Dr. Ines Mandl, who was the first woman to graduate from the Polytechnic Institute of Brooklyn (today's NYU Tandon School of Engineering) with a Ph.D. in chemistry in 1949.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    New York University (NYU). (2022, December 19). NYU Tandon professors show broad therapeutic potential of novel peptide to combat multiple diseases. AZoLifeSciences. Retrieved on October 04, 2024 from https://www.azolifesciences.com/news/20210831/NYU-Tandon-professors-show-broad-therapeutic-potential-of-novel-peptide-to-combat-multiple-diseases.aspx.

  • MLA

    New York University (NYU). "NYU Tandon professors show broad therapeutic potential of novel peptide to combat multiple diseases". AZoLifeSciences. 04 October 2024. <https://www.azolifesciences.com/news/20210831/NYU-Tandon-professors-show-broad-therapeutic-potential-of-novel-peptide-to-combat-multiple-diseases.aspx>.

  • Chicago

    New York University (NYU). "NYU Tandon professors show broad therapeutic potential of novel peptide to combat multiple diseases". AZoLifeSciences. https://www.azolifesciences.com/news/20210831/NYU-Tandon-professors-show-broad-therapeutic-potential-of-novel-peptide-to-combat-multiple-diseases.aspx. (accessed October 04, 2024).

  • Harvard

    New York University (NYU). 2022. NYU Tandon professors show broad therapeutic potential of novel peptide to combat multiple diseases. AZoLifeSciences, viewed 04 October 2024, https://www.azolifesciences.com/news/20210831/NYU-Tandon-professors-show-broad-therapeutic-potential-of-novel-peptide-to-combat-multiple-diseases.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of AZoLifeSciences.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Brain cells with the same birthdate display distinct connectivity