Biochemistry

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Hidden Role of Biliverdin Reductase A in Fighting Oxidative Damage

According to a new study from Johns Hopkins Medicine, the enzyme biliverdin reductase A (BVRA) protects neurons directly from oxidative stress, regardless of whether it produces the yellow pigment bilirubin.

5 Nov 2025

How Leucine Boosts Cellular Energy Production

Researchers at the University of Cologne have found that a particular dietary amino acid enhances cellular energy, thereby creating new opportunities for the treatment of metabolic disorders.

3 Nov 2025

Breakthrough Small Molecule Offers New Hope for Diabetes Treatment

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

31 Oct 2025

Unexpected Enzyme Strategy Behind Antibiotic Resistance

Researchers at McGill University have identified two enzymes that employ an unprecedented mechanism to provide resistance, thereby introducing a new dimension in the fight against antimicrobial resistance (AMR), which ranks among the top 10 global public health challenges.

31 Oct 2025

Researchers Uncover How Pseudomonas Bacteria Sense and Build Biofilms

The bacterium known as Pseudomonas aeruginosa is an unwelcome visitor in the human body. Serious infections can result when a bunch of these bugs settle together on a surface to form a biofilm - a community of microbes like the slime on spoiled food, but in this case residing inside a person.

29 Oct 2025

AI-Powered Approach Boosts Protein Production Efficiency in E. coli

Proteins sourced from microorganisms are attracting attention for their potential in biomanufacturing a variety of products, including pharmaceuticals, industrial enzymes, and diagnostic antibodies.

29 Oct 2025

Discovery of Hidden Antibiotic Offers Hope in the Fight Against Superbugs

Chemists from the University of Warwick and Monash University have discovered a promising new antibiotic that shows activity against drug-resistant bacterial pathogens, including MRSA and VRE.

28 Oct 2025

Discovery of Glucocorticoid Receptor Multimerization Opens Path to Safer Therapies

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR).

28 Oct 2025

Study Shows Flatulence Gas Hydrogen is Crucial for Gut Health

Farts are causing a stink in the research world, but in a positive way.

24 Oct 2025

Innovative Fluorescent Technique Sheds Light on Cellular Lipid Transport

Lipids are fatty molecules that play critical roles in cell function, including membrane structure, energy storage and nutrient absorption.

17 Oct 2025

PapB Could Make Ozempic-Style Drugs Stronger and Last Longer

Chemistry researchers at the University of Utah have discovered an enzyme referred to as PapB, which is capable of "tying off" therapeutic peptides, drugs resembling proteins, into compact rings, a process termed macrocyclization.

17 Oct 2025

Rare Spacecraft Bacterium Could Possibly Evade Detection by Entering Dormancy

A rare microorganism found in an unexpected environment may be evading detection by "playing dead," according to microbiologists at the University of Houston.

10 Oct 2025

Optimized Culture Conditions Reveal Hidden Antimicrobial Molecules in Dictyostelium

The cellular slime mold Dictyostelium discoideum is a soil microbe that produces diverse natural products with potential antibiotic activity.

10 Oct 2025

Smart Proteins Bring Precision Drug Delivery Closer to Reality

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint the exact areas of the body where they're needed - and nowhere they're not - can reduce the medicine dosage and avoid potentially harmful "off target" effects elsewhere in the body.

10 Oct 2025

Living Biofilms Act as Natural Batteries to Degrade Antibiotics at Night

Researchers have unveiled a surprising new way that soil microbes can use sunlight energy - even after the lights go out.

8 Oct 2025

Studies Uncover PAR2 Receptor’s Role in Gut Inflammation and Pain

Abdominal pain is common in a variety of digestive diseases, including inflammatory bowel disease and irritable bowel syndrome.

8 Oct 2025

New NMR Method Reveals How Enzymes Move During Reactions

Researchers from Tokyo Metropolitan University have developed a new structure determination method using Nuclear Magnetic Resonance (NMR) spectroscopy which shows how different parts of complex molecular machinery like enzymes move while they help catalyze reactions.

6 Oct 2025

Golden Broccoli Aptamer Enables Real-Time Measurement of Glycine

The amino acid glycine is an important neurotransmitter that regulates memory, reflex and brain development, and it may also be a biomarker for bacterial virulence.

6 Oct 2025

Comprehensive Proteomic Analysis with COOKIE-Pro Reveals Drug Affinity and Reactivity

Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent Occupancy Kinetic Enrichment via Proteomics) that provides a comprehensive, unbiased view of how a class of drugs, called covalent inhibitors, interacts with proteins throughout the cell.

30 Sep 2025

Cryo-EM Study Uncovers Hidden Steps in NMDA Receptor Activation

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, know that even slight changes in their activity level can mean the difference between normal function and serious neurological disorders.

25 Sep 2025