CRISPR News and Research

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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Understanding the architectures of proteins and the machinery at genes

Researchers from Cornell University have discovered a crucial mechanism in how genes are controlled thanks to yeast, a small organism that is necessary for the production of beer and bread.

1 Nov 2022

Pioneering gene editing approach could lead to new treatments for CTLA-4 insufficiency

A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.

From University College London 27 Oct 2022

Genome Editing Has A New Code

In this interview, we speak to Samantha Maragh, the leader of the genome editing program at NIST, about the genome editing vocabulary and what this means for researchers worldwide.

From National Institute of Standards and Technology (NIST) 21 Oct 2022

Broadening the scope of CRISPR-Cas9 genome editing systems

A group of Northwestern University researchers has created a novel gene editing platform that might influence the future application of a nearly infinite library of CRISPR-based therapeutics.

7 Oct 2022

Genomic research helps in tackling the fatal complications of fungal infections

An important genetic discovery made by a research team led by a University of Massachusetts Amherst scientist sheds new light on the application of the drug caspofungin to treat the deadly fungal infection Aspergillus fumigatus, which claims the lives of about 100,000 severely immunocompromised individuals every year.

7 Oct 2022

Making synthetic biology applications feasible using RNA origami

Synthetic biology aims to acquire comprehensive control over biological functions to produce designer organisms for a range of commercial, diagnostic, and therapeutic uses.

6 Oct 2022

Research team outlines three-step technique that lets human body defend against Hep B

A team from the University of Geneva (UNIGE) has unraveled the precise operation of this defensive mechanism after finding a crucial protein complex that is active when our body is infected by the virus, paving the path for novel treatment targets.

5 Oct 2022

Discovery of genes lending tolerance to sugarcane from pests, cold, and drought

Saccharum spontaneum, a species of wild sugarcane with exceptional resistance to biotic stresses like nematodes, fungi, bacteria, and other pests and diseases, as well as abiotic stresses like cold, drought, salinity, and nutritionally deficient soil, was the subject of a study at the State University of Campinas (UNICAMP) in Brazil.

28 Sep 2022

Chromosome restructuring suppresses meiotic recombination

The use of CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats) molecular scissors enables targeted editing, insertion, or suppression of genes in plants.

21 Sep 2022

Researchers reveal key developmental difference between the brains of modern humans and Neanderthals

AZoLifesciences speaks to Dr. Anneline Pinson and Prof. Dr. Wieland B. Huttner from The Max Planck Institute of Molecular Cell Biology and Genetics about their latest research which found a greater neuron production in the frontal lobe during brain development in modern humans than Neanderthals, due to the change of a single amino acid in the protein TKTL1.

From The Max Planck Institute 20 Sep 2022

Developing a comprehensive framework to regulate GE crops

A Policy Forum article calls for a new method of regulating genetically engineered crops, claiming that the current procedures for mandating safety testing are inconsistent internationally.

8 Sep 2022

A “stress test” with a previously unknown gene to revive the exhausted T cells

The task of battling cancer cells can fatigue T cells employed in immunotherapy treatments, or they could shut down once they penetrate tumors. Researchers at the Gladstone Institutes and UC San Francisco have strengthened the therapeutic cells’ resistance via a CRISPR-based edit on their genomes.

30 Aug 2022

New CRISPR RNA-guided Caspases could lead to promising antiviral and tissue engineering tools

New research from Cornell offers insights into a line of CRISPR systems, which could lead to promising antiviral and tissue engineering tools in animal and plants.

26 Aug 2022

The complex link between pancreatic malformations and the “dark genome”

For the first time, scientists at the Centre for Genomic Regulation (CRG) have discovered a DNA sequence that is essential for pancreatic development and function.

25 Aug 2022

Scientists uncover the robust mechanism used by insects

Researchers at IRB Barcelona, under the direction of Dr Marco Milan, have identified a very robust system that insects use for wing formation and regeneration.

25 Aug 2022

Defense mechanisms of horticulture crops against fungal infections

Recent research on defense responses of horticulture crops to fungal infections, novel ways to govern the induction of plant resistance, issues, challenges, and future research objectives have been summarized by scientists from the Chinese Academy of Sciences.

22 Aug 2022